Calcium Supplementation During Trauma Resuscitation In ICU Tue, 9 Jul 2024 In major trauma patients, ionised calcium levels (iCa2+) can be disrupted by injury, physiological imbalances, resuscitation strategies, and blood transfusions. Hypocalcaemia often results from the transfusion of citrate-containing blood products, as citrate binds to calcium, and this effect is exacerbated in cases of organ failure and massive transfusion. Other fluid resuscitat...

Original Investigation  Critical Care Medicine September 9, 2024 Sustained Performance of Cardiac Arrest Prevention in Pediatric Cardiac Intensive Care Units Dana Mueller, David K. Bailly, Mousumi Banerjee, et al JAMA Netw Open. 2024;7(9):e2432393. doi:10.1001/jamanetworkopen.2024.32393 Key Points Question  Can 17 hospitals maintain the reduced in-hospital cardiac arrest (IHCA) rate they achi...

Invited Commentary  September 9, 2024 Charting the Waters of Sickle Cell Disease With Target Trial Emulation A. Parker Ruhl, Matthew M. Hsieh, Elizabeth A. Stuart JAMA Intern Med. Published online September 9, 2024. doi:10.1001/jamainternmed.2024.4435 Large administrative databases hold promise for advancing biomedical care, like sails awaiting the winds of a clinically relevant question to navigate uncharted waters. However, making best use ...

Life-Saving Effect of Dexamethasone in COVID-19 In ICU Tue, 9 Jul 2024 Dexamethasone is a life-saving treatment for severe COVID-19, though patients exhibit varied responses to the therapy. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité – Universitätsmedizin Berlin have uncovered how this cortisone compound influences the impaired inflammatory response and which patients benefit from it. Their method, utilising singl...

Original Investigation  Critical Care Medicine September 11, 2024 Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy: A Randomized Clinical Trial Morten H. Bestle, Jakob Stensballe, Theis Lange, et al JAMA Netw Open. 2024;7(9):e2432444. doi:10.1001/jamanetworkopen.2024.32444 Key Points Question  What is the effect of administration of iloprost vs placebo on the sev...

Original Investigation  September 9, 2024 Lactated Ringer vs Normal Saline Solution During Sickle Cell Vaso-Occlusive Episodes Augusta K. Alwang, Anica C. Law, Elizabeth S. Klings, et al JAMA Intern Med. Published online September 9, 2024. doi:10.1001/jamainternmed.2024.4428 Key Points Question  What is the comparative effectiveness of lactated Ringer solution vs normal saline for fluid resuscit...

ARTICLES Volume 404, Issue 10457 P1019-1028 September 14, 2024 Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up Holger Thiele, Jacob E Møller, Jose P S Henriques, et al Lancet 2024: 404: 1019 - 1028 Summary Background Percutaneous active mechanical circulatory support (MCS) devices are being increasingly used in the treatment of acute myocar...

Research Long term exposure to road traffic noise and air pollution and risk of infertility in men and women: nationwide Danish cohort study Mette Sørensen, Aslak Harbo Poulsen, Bugge Nøhr, et al BMJ 2024; 386 doi: https://doi.org/10.1136/bmj-2024-080664 (Published 04 September 2024)Cite this as: BMJ 2024;386:e080664 Abstract Objective To investigate associations between long term residential exposure to road traffic noise and particulate matter with a...

Evaluating Remote Patient Monitoring for Reducing Return Visits to the Emergency Department In ICU Tue, 30 Apr 2024 Return visits to the emergency department (ED) pose a challenge to healthcare organisations, with significant financial and care implications. About 20% of patients return to the ED within 30 days, with some visits being preventable. Factors contributing to return visits include fear, anxiety, convenience, and expedited evaluation. While ...

Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial Liu, L., Sun, Q., Zhao, H. et al. Intensive Care Med 50, 1298–1309 (2024) https://doi.org/10.1007/s00134-024-07545-x Abstract Purpose Awake prone positioning has been reported to reduce endotracheal intubation in patients with coronavirus disease 2019 (COVID-19)-related acute hypoxemic respiratory failure (AHRF). H...