Original Investigation  Pharmacy and Clinical Pharmacology September 26, 2024 Tongxinluo and Functional Outcomes Among Patients With Acute Ischemic Stroke: A Randomized Clinical Trial Yi Dong, Kaifu Jiang, Zhenguang Li, et al JAMA Netw Open. 2024;7(9):e2433463. doi:10.1001/jamanetworkopen.2024.33463 Key Points Question  Can the antioxidant drug Tongxinluo, which consists of 12 traditional Chi...

Original Investigation  Health Policy September 27, 2024 Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis Maximilian Salcher-Konrad, Mary Nguyen, Jelena Savović, et al JAMA Netw Open. 2024;7(9):e2436230. doi:10.1001/jamanetworkopen.2024.36230 Key Points Question  How do treatment effects for drugs compare when obtained from nonrandomi...

Editorial  September 25, 2024 Feasibility of Fever Prevention in Vascular Brain Injury Teresa May, Lori Shutter JAMA. Published online September 25, 2024. doi:10.1001/jama.2024.16415 How to manage fever in the neurocritical care unit in patients with acute stroke was clearly a question in need of an answer. The association of fever burden with poor outcome for diverse conditions in the neurocritical care unit has been well described.1-3 Howev...

Perioperative Cardiac Output Monitoring: From Yellow Catheters to Green Algorithms In ICU Fri, 17 May 2024 We discuss the economic and environmental advantages of green pulse wave analysis (PWA) techniques and the integration of PWA algorithms into standard bedside monitors that will likely contribute to democratisation of perioperative cardiac output monitoring. Haemodynamic instability frequently manifests during the perioperative course of high-risk ...

Original Investigation  Equity, Diversity, and Inclusion September 24, 2024 Race and Sex Disparities Among Emergency Medicine Chief Residents Jennifer W. Tsai, Mytien Nguyen, Sarah N. Dudgeon, et al JAMA Netw Open. 2024;7(9):e2432679. doi:10.1001/jamanetworkopen.2024.32679 Key Points Question  Do racial disparities for selecting emergency medicine chief residency exist? Findings  ...

Original Investigation  Pediatrics September 25, 2024 Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trial Francesca Gallini, Domenico Umberto De Rose, Roberta Iuliano, et al JAMA Netw Open. 2024;7(9):e2435347. doi:10.1001/jamanetworkopen.2024.35347 Key Points Question  Did infants who underwent the intubate-recruit-s...

ONLINE FIRST (FREE ACCESS) "ICU TOOLBOX" TOPICAL COLLECTION Editorial Monitoring cardiac output De Backer D., Hajjar L. and Monnet X. "MY GREEN ICU" COLLECTION CorrespondenceHow a green team can rapidly lower the carbon footprint of paracetamol route use in intensive careGisbert-Mora C. et al LATEST ARTICLES Original Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a ...

Original Investigation  September 25, 2024 Fever Prevention in Patients With Acute Vascular Brain Injury: The INTREPID Randomized Clinical Trial David M. Greer, Raimund Helbok, Neeraj Badjatia, et al JAMA. Published online September 25, 2024. doi:10.1001/jama.2024.14745 Key Points Question  Is an automated surface temperature management device effective in prevention of fever in patients with ac...

Reversal of Direct Oral Anticoagulants In ICU Tue, 30 Jul 2024 Direct oral anticoagulants (DOACs) like apixaban, edoxaban, rivaroxaban (all FXa inhibitors), and dabigatran (a thrombin inhibitor) have been used for many years, with their generic versions becoming increasingly available. Though DOACs have a lower risk of serious bleeding, such as intracranial haemorrhage, compared to vitamin K antagonists, bleeding is still their most common side effect....

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 GBD 2021 Antimicrobial Resistance Collaborators Lancet 2024; 404: 1199-1226 Summary Background Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed estimates for sev...