Respiratory syncytial virus infection among children younger than 2 years admitted to a paediatric intensive care unit with extended severe acute respiratory infection in ten Gavi-eligible countries: the RSV GOLD—ICU Network study RSV GOLD—ICU Network collaborators Lancet Global Health 2024; 12: e1611-e1619 Summary Background Patient-level data on life-threatening respiratory syncytial virus (RSV) infection in children in low-income and lower-middle-income ...

Evaluating national infection prevention and control minimum requirements: evidence from global cross-sectional surveys, 2017–22 Ermira Tartari, Sara Tomczyk, Anthony Twyman, et al. Lancet Global Health 2024; 12: e1620-e1628 Summary Background WHO infection prevention and control (IPC) minimum requirements provide standards to reduce the risk of infection during health-care delivery. We aimed to investigate the global implementation of these requirements at...

Interprofessional Familiarity Improves Outcomes in Mechanically Ventilated Adults In ICU Mon, 5 Aug 2024 Over 1 million patients with acute respiratory failure requiring mechanical ventilation are admitted to ICUs every year, with a one-in-five mortality rate. While interventions like lung-protective ventilation, prone positioning, and protocols such as spontaneous awakening and breathing trials are crucial, there's a growing interest in optimising sta...

Research Letter  October 10, 2024 Payments by Drug and Medical Device Manufacturers to US Peer Reviewers of Major Medical Journals David-Dan Nguyen, Anju Muramaya, Anna-Lisa Nguyen, et al JAMA. Published online October 10, 2024. doi:10.1001/jama.2024.17681 Although conflicts of interest of journal editors and authors have been investigated,1,2 the traditionally opaque nature of peer review has hindered their...

Review  August 12, 2024 Perioperative Management of Patients Taking Direct Oral Anticoagulants: A Review James D. Douketis, Alex C. Spyropoulos JAMA. Published online August 12, 2024. doi:10.1001/jama.2024.12708 Abstract Importance  Direct oral anticoagulants (DOACs), comprising apixaban, rivaroxaban, edoxaban, and dabigatran, are commonly used medications to treat patients with atrial fibrillation and venous ...

Prolonged vs Shorter Awake Prone Positioning - COVID-19 With Acute Respiratory Failure In ICU Mon, 5 Aug 2024 Awake prone positioning has been shown to reduce endotracheal intubation in patients with COVID-19-related acute hypoxaemic respiratory failure (AHRF). This method has also become standard care for patients with moderate to severe acute respiratory distress syndrome (ARDS).  During the COVID-19 pandemic, studies suggested that awak...

Original Investigation  Cardiology August 21, 2024 Sex, Atrial Fibrillation, and Long-Term Mortality After Cardiac Surgery Sergey Karamnov, Natalia Sarkisian, Jakob Wollborn, et al JAMA Netw Open. 2024;7(8):e2426865. doi:10.1001/jamanetworkopen.2024.26865 Key Points Question  Do the incidence of postoperative atrial fibrillation (poAF) and associated long-term mortality after cardiac surgery ...

Prolonged awake prone positioning in COVID-19: recommendations and outlook Lei, R., Yue, C., Li, R. et al. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07640-z We read with great interest the article by Liu et al. recently published in Intensive Care Medicine [1]. This landmark study conducted a multicenter, randomized controlled trial to evaluate the effects of prolonged versus shorter awake prone positioning on intubation rates and mortality in...

Original Investigation  May 19, 2024 Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial Graham Devereux, Seonaidh Cotton, Mintu Nath, et al JAMA. 2024;332(6):462-470. doi:10.1001/jama.2024.8771 Key Points Question  For people with chronic obstructive pulmonary disease (COPD) at high risk of exacerbations, does bisoprolol reduc...

Barriers to Female Leadership in Intensive Care Medicine In ICU Mon, 26 Aug 2024 The field of intensive care medicine faces a significant gender imbalance in leadership positions, with women underrepresented due to various factors, including gender bias, societal messages, and a confidence gap that leads to self-censorship. Many qualified women face obstacles like outdated leadership models and systemic biases, which hinder their advancement. To add...