ARTICLES|ONLINE FIRST Assessing COVID-19 pandemic policies and behaviours and their economic and educational trade-offs across US states from Jan 1, 2020, to July 31, 2022: an observational analysis Thomas J Bollyky, Emma Castro, Aleksandr Y Aravkin, et al Lancet Published:March 23, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00461-0 Summary Background The USA struggled in responding to the COVID-19 pandemic, but not all states struggled equally. I...

ARTICLES|ONLINE FIRST Evaluating the impact of alcohol minimum unit pricing on deaths and hospitalisations in Scotland: a controlled interrupted time series study Grant M A Wyper, Daniel F Mackay, Catriona Fraser, et al. Lancet Published:March 20, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00497-X Summary Background Since May 1, 2018, every alcoholic drink sold in Scotland has had minimum unit pricing (MUP) of £0·50 per unit. Previous studies have...

ORIGINAL ARTICLE Covid-19 Surveillance Testing and Resident Outcomes in Nursing Homes Brian E. McGarry, Ashvin D. Gandhi, Michael L. Barnett N Engl J Med 2023; 388:1101-1110DOI: 10.1056/NEJMoa2210063 Abstract BACKGROUND Despite widespread adoption of surveillance testing for coronavirus disease 2019 (Covid-19) among staff members in skilled nursing facilities, evidence is limited regarding its relationship with outcomes among facility residents. METHO...

ORIGINAL ARTICLE Acute Effects of Coffee Consumption on Health among Ambulatory Adults Gregory M. Marcus, David G. Rosenthal, Gregory Nah, et al N Engl J Med 2023; 388:1092-1100DOI: 10.1056/NEJMoa2204737 Abstract BACKGROUND Coffee is one of the most commonly consumed beverages in the world, but the acute health effects of coffee consumption remain uncertain. METHODS We conducted a prospective, randomized, case-crossover trial to examine the effects...

Original Investigation  Caring for the Critically Ill Patient March 21, 2023 Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial Pierre Bouzat, Jonathan Charbit, Paer-Selim Abback, et al JAMA. Published online March 21, 2023. doi:10.1001/jama.2023.4080 Key Points Question  Does 4-factor prothrombin ...

Original Investigation  Caring for the Critically Ill Patient March 21, 2023 Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19 Ewan C. Goligher, Patrick R. Lawler, Thomas P. Jensen, et al JAMA. Published online March 21, 2023. doi:10.1001/jama.2023.3651 Key Points Question  What patient characteristics are associated with benefit or harm of therapeutic-dose heparin in patients ho...

ARTICLES|ONLINE FIRST Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:April 12, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00510-X Summary Background Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or vent...

Research Comparison of mental health symptoms before and during the covid-19 pandemic: evidence from a systematic review and meta-analysis of 134 cohorts Ying Sun, Yin Wu, Suiqiong Fan, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-074224 (Published 08 March 2023)Cite this as: BMJ 2023;380:e074224 Abstract Objective To synthesise results of mental health outcomes in cohorts before and during the covid-19 pandemic. Design Systematic ...

Research Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records Yan Xie, Benjamin Bowe, Ziyad Al-Aly BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072705 (Published 07 March 2023)Cite this as: BMJ 2023;380:e072705 Abstract Objective To emulate a randomized target trial to estimate the association between the antiviral drug molnupiravir and hospital admis...

ARTICLES|ONLINE FIRST Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study James Peter Allinson, Nishi Chaturvedi, Andrew Wong, et al. Lancet Published:March 07, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00131-9 Summary Background Lower respiratory tract infections (LRTIs) in early childhood are known to influence lung development and lifelong lung hea...