ORIGINAL ARTICLE Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm Jean-Baptiste Lascarrou, Hamid Merdji, Amélie Le Gouge, et al N Engl J Med October 2, 2019DOI: 10.1056/NEJMoa1906661 BACKGROUND 背景 Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate therapeutic hypothermia i...

ARTICLES| VOLUME 7, ISSUE 7, P581-593, JULY 01, 2019 Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial Michael Levin, Aubrey J Cunnington, Clare Wilson, et al Lancet Respir Med 2019; 7: 581-593 DOI:https://doi.org/10.1016/S2213-2600(19)30114-6 Background 背景 Fluid resuscitation is the recommended management of shock, but increased mortality in febrile African children in the FEAST trial. ...

ORIGINAL ARTICLE Conservative Oxygen Therapy during Mechanical Ventilation in the ICU The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med October 14, 2019DOI: 10.1056/NEJMoa1903297 BACKGROUND 背景 Patients who are undergoing mechanical ventilation in the intensive care unit (ICU) often receive a high fraction of inspired oxygen (Fio2) and have a high arterial oxygen tension. The conservative...

Biotech Innovations October 8, 2019 Cuffless Blood Pressure Monitoring Jennifer Abbasi JAMA. 2019;322(14):1343. doi:10.1001/jama.2019.15537 Asmartphone video-based measurement tool accurately predicted blood pressure (BP) readings in a proof-of-concept study recently published in Circulation: Cardiovascular Imaging. The technology, dubbed transdermal optical imaging, records facial blood flow using a standard smartphone video came...

Preliminary Communication Caring for the Critically Ill PatientOctober 1, 2019 Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Alpha A. Fowler III, Jonathon D. Truwit, R. Duncan Hite, et al JAMA. 2019;322(13):1261-1270. doi:10.1001/jama.2019.11825 Importanc...

Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016 Charles L. Sprung, Bara Ricou, Christiane S. Hartog, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14608 Importance 背景 End-of-life decisions occur daily in intensive care units (ICUs) around the world, and these practices ...

#LIVES2019: Are Printed Journals Obsolete? In an interesting session today @ESICM #LIVES2019 in Berlin, Dr. Adrian Wong, Consultant, Intensive Care Medicine and Anaesthesia, Royal Surrey County Hospital, UK, presented his views about printed journals and their purpose in the digital age. Dr. Wong began with a short history of the first scientific journal devoted to science which was published in 1665 - The Philosophical Transaction of the Royal Society. The full...

Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial Arnaud W. Thille, Grégoire Muller, Arnaud Gacouin, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14901 Importanc...

#LIVES2019: Findings from the DIANA Study Liesbet De Bus of Ghent University Hospital, Belgium, presented the findings of the DetermInants of Antimicrobial use aNd de-escalAtion (DIANA) study @ESICM #LIVES2019 in Berlin. Dr. De Bus started off by explaining the concept of de-escalation and how it is all about finding a balance between early adequate antimicrobial therapy on the one hand and reducing unnecessary exposure to antimicrobials on the other hand, mainl...

Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial Pierre-Francois Laterre, Scott M. Berry, Allan Blemings, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14607 Importance 背景 Norepinephrine, the first-line vasopr...