CORRESPONDENCE Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy N Engl J Med April 29, 2020DOI: 10.1056/NEJMc2010418 TO THE EDITOR: Despite the risk of rapid respiratory failure1 and cardiac complications2 due to Covid-19, it is unclear whether there is an association between Covid-19 and out-of-hospital cardiac arrest. The Lombardy region of Italy was among the first areas to have an outbreak of Covid-19 outside China,3 and ...

Original Investigation May 11, 2020 Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State Eli S. Rosenberg, PElizabeth M. Dufort, Tomoko Udo, et al JAMA. Published online May 11, 2020. doi:10.1001/jama.2020.8630 Abstract Importance Hydroxychloroquine, with or without azithromycin, has been considered as a possible therapeutic agent for patients with coronavir...

ORIGINAL ARTICLE Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Joshua Geleris, Yifei Sun, Jonathan Platt, et al N Engl J Med May 7, 2020DOI: 10.1056/NEJMoa2012410 Abstract BACKGROUND Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use. METHODS We examined the association between hydroxychloroquine use and intubation or death at a large medical center...

ARTICLES|ONLINE FIRST Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Giulio Cavalli, Giacomo De Luca, Corrado Campochiaro, et al Lancet Rheumatol Published:May 07, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30127-2 Summary Background Mortality of patients with coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARD...

ARTICLES|ONLINE FIRST Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial Ivan Fan-Ngai Hung, Kwok-Cheung Lung, Eugene Yuk-Keung Tso, et al Lancet Published:May 08, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31042-4 Summary Background Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVI...

JAMA Insights Clinical UpdateMarch 11, 2020 Care for Critically Ill Patients With COVID-19 Srinivas Murthy, Charles D. Gomersall, Robert A. Fowler JAMA. 2020;323(15):1499-1500. doi:10.1001/jama.2020.3633 Initial reports suggest that COVID-19 is associated with severe disease that requires intensive care in approximately 5% of proven infections.1 Given how common the disease is becoming, as in prior major severe acute respiratory infection outbreaks—S...

Original Investigation April 22, 2020 Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Safiya Richardson, Jamie S. Hirsch, Mangala Narasimhan, et al JAMA. Published online April 22, 2020. doi:10.1001/jama.2020.6775 Abstract Importance There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for...

May 6, 2020 Interpreting Diagnostic Tests for SARS-CoV-2 Nandini Sethuraman, Sundararaj Stanleyraj Jeremiah, Akihide Ryo JAMA. Published online May 6, 2020. doi:10.1001/jama.2020.8259 The pandemic of coronavirus disease 2019 (COVID-19) continues to affect much of the world. Knowledge of diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still evolving, and a clear understanding of the nature of the tests and interpre...

ORIGINAL ARTICLE Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19 Harmony R. Reynolds, Samrachana Adhikari, Claudia Pulgarin, et al N Engl J Med May 1, 2020DOI: 10.1056/NEJMoa2008975 Abstract BACKGROUND There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiot...

ORIGINAL ARTICLE Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19 Giuseppe Mancia, Federico Rea, Monica Ludergnani, et al N Engl J Med May 1, 2020DOI: 10.1056/NEJMoa2006923 Abstract BACKGROUND A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied. METHODS We carried out a po...