ARTICLES|ONLINE FIRST Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial Toby Richards, Ravishankar Rao Baikady, Ben Clevenger, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31539-7 Summary 摘要 Background 背景 Preoperative anaemia affects a high proportion of patients undergoing major elective surgery and is associated with poor outc...

HealthManagement, Volume 20 - Issue 5, 2020 COVID-19 Antibody Testing – Why it Matters and Factors to Consider As we move into the next phase of the COVID-19 pandemic, there will be a need to test a broad strata of population, much more than what molecular tests can handle. The solution lies with serological tests. As the world continues the fight against COVID-19, healthcare executives are in an uncomfortable position – having to make critical decisions wit...

PulmCrit – Splitting ventilators to provide titrated support to a large group of patients March 15, 2020 by Josh Farkas COVID-19 might out-strip the number of mechanical ventilators available to us.  This has led to interest in using a single ventilator to support multiple patients.  This post will review the theory and evidence regarding this (with the admission that I don’t have experience with this).  basic principles Bedrock principle: ...

ARTICLES|ONLINE FIRST Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study Richard Kuehl, Laura Morata, Christian Boeing, et al Lancet Infect Dis Published:August 04, 2020 DOI:https://doi.org/10.1016/S1473-3099(20)30447-3 Summary 摘要 Background 背景 Staphylococcus aureus persistent bacteraemia is only vaguely defined and the effect of different durations of bacteraemia on mortality is not well establish...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Is COVID-19 the Black Swan? Nassim Taleb, in his book, "The Black Swan: The Impact of the Highly Improbable," describes the term Black Swan as a rare, unknown event, which with hindsight is rationalised. Taleb talks about the human tendency to always find simplistic explanations for unknown events, what he calls the Black Swan theory. Is COVID-19 a black swan? Introduction Physicians working with cr...

ARTICLES| VOLUME 396, ISSUE 10251, P603-611, AUGUST 29, 2020 Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study Barnaby E Young, Siew-Wai Fong, Yi-Hao Chan, et al Lancet 2020; 396: 603-611 Summary 摘要 Background 背景 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) regio...

COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study Jessica J Manson, Colin Crooks, Meena Naja, et al Lancet Rheumatol Published:August 21, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30275-7 Summary Background 背景 A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-1...

ARTICLES| VOLUME 20, ISSUE 4, P425-434, APRIL 01, 2020 Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Heshui Shi, Xiaoyu Han, Nanchuan Jiang, et al Lancet Infect Dis 2020; 20: 425-434 Summary 摘要 Background 背景 A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuh...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Sleep Deprivation and Fatigue Management in the Intensive Care Unit The impact of sleep deprivation and fatigue on patients and staff in the intensive care unit and how improved sleep, reduced noise disturbances, and more organised shifts could be beneficial for both patients and clinicians. The World Health Organization (WHO) recommends that average daily sound levels in patient care areas should be a...

Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study Matthieu Schmidt, David Hajage, Guillaume Lebreton Lancet Respir Med Published:August 13, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30328-3 Summary 摘要 Background 背景 Patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and...