Original Investigation Caring for the Critically Ill PatientOctober 4, 2021 Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial Writing Committee for the REMAP-CAP Investigators JAMA. Published online October 4, 2021. doi:10.1001/jama.2021.18178 Abstract Importance  The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is i...

Original Investigation October 5, 2021 Effect of a Pulmonary Embolism Diagnostic Strategy on Clinical Outcomes in Patients Hospitalized for COPD Exacerbation: A Randomized Clinical Trial David Jiménez, Alvar Agustí, Eva Tabernero, et al JAMA. 2021;326(13):1277-1285. doi:10.1001/jama.2021.14846 Abstract Importance  Active search for pulmonary embolism (PE) may improve outcomes in patients hospitalized for exacerbations of chronic obs...

Original Investigation Caring for the Critically Ill PatientOctober 5, 2021 Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial Harriëtte J. van Esch, Lia van Zuylen, Eric C. T. Geijteman, et al JAMA. 2021;326(13):1268-1276. doi:10.1001/jama.2021.14785 Abstract Importance  Death rattle, defined as noisy breathing caused by the presence of ...

Original Investigation September 29, 2021 Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial Lars W. Andersen, Dan Isbye, Jesper Kjærgaard, et al JAMA. Published online September 29, 2021. doi:10.1001/jama.2021.16628 Abstract Importance  Previous trials have suggested that vasopressin and methylprednisolone administered...

Original Investigation Caring for the Critically Ill PatientOctober 21, 2021 Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial The COVID STEROID 2 Trial Group JAMA. Published online October 21, 2021. doi:10.1001/jama.2021.18295 Abstract Importance  A daily dose with 6 mg of dexamethasone is recommended for up to...

Research Procalcitonin and lung ultrasonography point-of-care testing to determine antibiotic prescription in patients with lower respiratory tract infection in primary care: pragmatic cluster randomised trial Loïc Lhopitallier, Andreas Kronenberg, Jean-Yves Meuwly, et al BMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n2132 (Published 21 September 2021)Cite this as: BMJ 2021;374:n2132 Abstract Objective To assess whether point-of care procalcitonin and...

ICU Management & Practice, Volume 21 - Issue 2, 2021 If It’s Good for Calcium Why Not Magnesium? Reasons to Measure iMg in the ICU An overview of the importance of getting magnesium levels right in critically ill patients and the role ionised magnesium plays. Background Like all electrolytes, magnesium exists in the bloodstream in “bound” states, and in “free” or “ionised” states, which is the portion that is physiologically active. This ionised compo...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 160, ISSUE 1, P148-156, JULY 01, 2021 The Effect of Reconnection to Mechanical Ventilation for 1 Hour After Spontaneous Breathing Trial on Reintubation Among Patients Ventilated for More Than 12 Hours: A Randomized Clinical Trial Michelli M. Dadam, Anderson R.R. Gonçalves, Gilvania L. Mortari, et al Chest 2021; 160: 148-156 Background The resting of the respiratory musculature after undergoing the spon...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 160, ISSUE 2, P499-508, AUGUST 01, 2021 Continuous Pneumatic Regulation of Tracheal Cuff Pressure to Decrease Ventilator-associated Pneumonia in Trauma Patients Who Were Mechanically Ventilated: The AGATE Multicenter Randomized Controlled Study Nicolas Marjanovic, Matthieu Boisson, Karim Asehnoune, et al Chest 2021; 160: 499-508 Background Ventilator-associated pneumonia (VAP) is the most frequent heal...

ICU Management & Practice, Volume 21 - Issue 2, 2021 ICU Mental Health in the Ongoing Pandemic: How Will We Be Okay? After a year of this pandemic, this article explores what we currently understand about the psychological impact experienced by ICU teams and provides practical guidance to help build personal and team resilience as the journey with COVID-19 continues with no end in sight. Introduction When COVID-19 emerged as a new pathogen, the pictur...