Medical News & Perspectives  June 8, 2022 From Positive to Negative to Positive Again—The Mystery of Why COVID-19 Rebounds in Some Patients Who Take Paxlovid Rita Rubin JAMA. Published online June 8, 2022. doi:10.1001/jama.2022.9925 David Ho, MD, managed to avoid contracting COVID-19 for more than 2 years. But SARS-CoV-2 finally got the best of the pioneering HIV researcher on an April trip to Paris for, of all things, a 2-day COVID-19...

Original Investigation  January 27, 2022 Clinical Characteristics and Outcomes of Patients With COVID-19–Associated Acute Respiratory Distress Syndrome Who Underwent Lung Transplant Chitaru Kurihara, Adwaiy Manerikar, Melissa Querrey, et al JAMA. 2022;327(7):652-661. doi:10.1001/jama.2022.0204 Key Points Question  What were the clinical outcomes of patients who underwent a lung transplant after developing COVID-19–associated acute respirat...

Long COVID and Recovery Following Hospitalisation More than 500 million cases of COVID-19 have been reported worldwide. Patients infected with COVID-19 are at a higher risk of persisting health impairments six months after hospital discharge associated with reduced physical function and health and quality of life. It is thus important to understand the long-term trajectory of recovery from COVID-19. There is very limited information about the long-term sequelae ...

Original Investigation  June 5, 2022 Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial Ethan Basch, Deborah Schrag, Sydney Henson, et al JAMA. Published online June 5, 2022. doi:10.1001/jama.2022.9265 Key Points Question  In patients undergoing cancer treatment, does electronic symptom monitoring improve quality-of-life (QOL) outcomes? Findin...

Research Letter  June 13, 2022 Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021 Jefferson M. Jones, Jean D. Opsomer, Mars Stone, et al JAMA. Published online June 13, 2022. doi:10.1001/jama.2022.9745 By testing for both SARS-CoV-2 spike and nucleocapsid antibodies, seroprevalence studies can estimate the proportion of a population with antibodies from previous infe...

Viewpoint  June 7, 2022 Reducing SARS-CoV-2 in Shared Indoor Air Deborah Dowell, William G. Lindsley, John T. Brooks JAMA. Published online June 7, 2022. doi:10.1001/jama.2022.9970 SARS-CoV-2 replicates in the respiratory tract and spreads through exhalation of infectious respiratory particles. The chances of transmission increase the longer an uninfected person stays in an enclosed space with an infected person. Infection can occur not only ...

Research Effectiveness of heterologous and homologous covid-19 vaccine regimens: living systematic review with network meta-analysis Wing Ying Au, Peter Pak-Hang Cheung BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2022-069989 (Published 31 May 2022)Cite this as: BMJ 2022;377:e069989 Abstract Objective To evaluate the effectiveness of heterologous and homologous covid-19 vaccine regimens with and without boosting in preventing covid-19 related infecti...

ARTICLES| VOLUME 399, ISSUE 10342, P2191-2199, JUNE 11, 2022 Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases Hui-Lee Wong, Mao Hu, Cindy Ke Zhou, et al Lancet 2022; 399: 2191-2199 Summary Background Several passive surveillance systems reported increased risks of myocarditis or pericarditis, or both, after COVID-19 mRNA vaccination, especially in young men. We used act...

ARTICLES| VOLUME 399, ISSUE 10342, P2212-2225, JUNE 11, 2022 Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6–17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial Grace Li, Federica Cappuccini, Natalie G Marchevsky, et al Lancet 2022; 399: 2212-2225 Summary Background Vaccination of children and young people against SARS-CoV-2 is recommended in some countries. S...

Medical News & Perspectives May 18, 2022 SARS-CoV-2 RNA Can Persist in Stool Months After Respiratory Tract Clears Virus Rita Rubin, MA JAMA. Published online May 18, 2022. doi:10.1001/jama.2022.7892 SARS-CoV-2, or at least pieces of it, sticks around longer in some infected individuals than respiratory sample testing would suggest, a recent study found. After respiratory samples tested negative, a small proportion of the 113 study pa...