Original Investigation May 13, 2022 Association of Prior BNT162b2 COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection in Children and Adolescents During Omicron Predominance Katherine E. Fleming-Dutra, Amadea Britton, Nong Shang, et al JAMA. Published online May 13, 2022. doi:10.1001/jama.2022.7493 Key Points Question  Does the estimated effectiveness of 2 doses of the BNT162b2 COVID-19 vaccine against symptomatic SARS-CoV-2 ...

ARTICLES|ONLINE FIRST Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial Alasdair P S Munro, Shuo Feng, Leila Janani, et al Lancet Infect Dis Published:May 09, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00271-7 Summary Background Some high-in...

ARTICLES| VOLUME 399, ISSUE 10340, P2047-2064, MAY 28, 2022 Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis You Li, Xin Wang, Dianna M Blau, et al Lancet 2022; 399: 2047-2064 Summary Background Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infection in young...

ARTICLES|ONLINE FIRST Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study Edward Burn, Talita Duarte-Salles, Sergio Fernandez-Bertolin, et al Lancet Infect Dis Published:May 13, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00223-7 Summary Background There are few data on the incidence of thrombosis among COVID-19 cases, with most research concentrated on hospitalised patients. We aimed to estimate the incid...

Original Investigation May 15, 2022 Effect of Robot-Assisted Radical Cystectomy With Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients With Bladder Cancer: A Randomized Clinical Trial James W. F. Catto, Pramit Khetrapal, Federico Ricciardi, et al JAMA. Published online May 15, 2022. doi:10.1001/jama.2022.7393 Key Points Question  Does robot-assisted surgery improve periopera...

CORRESPONDENCE Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults Patrick E. Brown, Sze Hang Fu, Aiyush Bansal, et al N Engl J Med May 18, 2022DOI: 10.1056/NEJMc2202879 TO THE EDITOR: The incidence of the omicron BA.1/1.1 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which rapidly spread worldwide even among vaccinated persons, is incompletely defined.1 We quantified the incidence of SARS-CoV-2 infection d...

ARTICLES|ONLINE FIRST Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials National Institute of Health Research Unit on Global Surgery Lancet Infect Dis Published:May 26, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00133-5 Summary Background WHO and the UK's National Institute for Health and Care Excellence recommen...

ORIGINAL ARTICLE Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 Yair Goldberg, Micha Mandel, Yinon M. Bar-On, et al N Engl J Med May 25, 2022DOI: 10.1056/NEJMoa2118946 Abstract BACKGROUND Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the immunity provided by the BNT162b2 vaccine. The time course of natural and hybrid immuni...

ARTICLES|ONLINE FIRST Global impact of the first year of COVID-19 vaccination: a mathematical modelling study Oliver J Watson, Gregory Barnsley, Jaspreet Toor, et al Lancet Infect Dis Published:June 23, 2022 DOI: https://doi.org/10.1016/S1473-3099(22)00320-6 Summary Background The first COVID-19 vaccine outside a clinical trial setting was administered on Dec 8, 2020. To ensure global vaccine equity, vaccine targets were set by the COVID-19 Vaccines G...

Original Investigation May 17, 2022 Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial Jicheng Lv, Muh Geot Wong, Michelle A. Hladunewich, et al JAMA. 2022;327(19):1888-1898. doi:10.1001/jama.2022.5368 Key Points Question  What are the effects of oral glucocorticoids in patients with IgA nephropathy and proteinuria of 1 g per day o...