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Precision Medicine and COVID-19 Precision medicine has been an important goal in healthcare. Researchers have been focused on generating new disease subclassifications to maximise individualised treatment options. There have been many phenotypes, endotypes, and subtypes so that patients who demonstrate specific symptoms and fall into a specific subtype or phenotype can be treated with precision. The same is true for SARS-CoV-2. To date, more than 60 subtypes hav...
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Cardiopulmonary Resuscitation in COVID-19 Patients Experiencing In-Hospital Cardiac Arrest COVID-19 continues to infect people across the globe, and the United States continues to be one of the most affected regions in the world. Coronavirus primarily affects the respiratory system through angiotensin-converting enzyme (ACE) 2 receptor on host cells. It also affects other systems because ACE2 is present in the heart, GI tract and kidneys. Infection with COVID-19 leads ...
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Effect of Vitamin D in Patients with Moderate to Severe COVID-19 A clinical trial was conducted to evaluate the effect of a single high dose of vitamin D3 on hospital length of stay among hospitalised patients with moderate to severe COVID-19.  Vitamin D is believed to enhance innate and adaptive immunity. A deficiency of vitamin D is known to be a potential risk for non-communicable and acute respiratory tract diseases, including viral infections. During ...
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Editorial August 10, 2021 Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU? Michael J. Connor Jr, Craig M. Coopersmith JAMA. Published online August 10, 2021. doi:10.1001/jama.2021.11119 Administration of intravenous fluids is among the most common interventions performed in intensive care units (ICUs). The first description of fluids for resuscitation of a critically ill patie...
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EDITORIAL Surviving Covid-19 with Heparin? Hugo ten Cate N Engl J Med August 4, 2021DOI: 10.1056/NEJMe2111151 Patients who are admitted to the hospital with coronavirus disease 2019 (Covid-19) are at high risk for thrombosis, particularly venous thromboembolism (VTE). In a meta-analysis of 66 studies, the overall prevalence of VTE among patients with Covid-19 was 14.1%, with the highest incidence (22.7%) among those admitted to intensive care units (ICUs).1&nb...
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Editorial July 6, 2021 IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How? Michael A. Matthay, Anne F. Luetkemeyer JAMA. Published online July 6, 2021. doi:10.1001/jama.2021.11121 Although substantial progress has been made in the treatment and prevention of COVID-19, more effective treatments for patients with COVID-19 who require hospitalization are still needed. One promising immunomodulatory strategy ...
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12 Things to Do to Improve Wellbeing in the ICU An overview of strategies and measures that can be implemented to improve wellbeing of staff and patients in the ICU. 1. Make the patient the centre of our preoccupations This is the first principle of wellbeing in the ICU and should be written in large letters when one enters an ICU. Wellbeing must concern first and foremost the patient. The patient should be positioned, figuratively, at the centre of the ICU room,...
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Post-Acute Sequalae of COVID-19 Findings from a large comprehensive study of COVID-19 show that COVID-19 survivors - even those with mild symptoms - have to deal with a variety of health problems long after the infection has resolved. Study findings show that COVID-19 survivors, including those not hospitalised, had an increased risk of death six months after a COVID-19 diagnosis.  These findings highlight the long-term burden of this disease and how i...
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Antibiotic Delay Intervals, Mortality Among Patients With Suspected Sepsis Timely delivery of antibiotics is a major cornerstone of sepsis therapy. Clinical evidence suggests that every one-hour delay in antibiotics after emergency department (ED) triage or the onset of organ dysfunction or shock could result in a 3-7% increase in the odds of a poor outcome. The Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic initiation within one hour of ED triage,...
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5G-Powered Robot-Assisted Teleultrasound Diagnostic System In situations where there are limited medical resources and a lack of expertise, and where the risk of infection is also high, teleultrasound can provide an effective solution.  A study was conducted to explore the feasibility of the application of a 5G-powered robot-assisted teleultrasound diagnostic system in an ICU. Robot-assisted ultrasound diagnostic systems allow dynamic observation ...
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