Prevalence, Risk of Mortality of Antimicrobial Resistance - A Global Review In ICU Tue, 26 Aug 2025 Antimicrobial resistance (AMR) is a major global health threat, with rising prevalence worsened by the COVID-19 pandemic. Hospitals are particularly high-risk environments for AMR due to heavy antibiotic use and vulnerable patient populations. Contributing factors include increased virulence, reduced antibiotic effectiveness, improper dosing, and ageing ...

Healthcare Costs After Sepsis In Sepsis Tue, 26 Aug 2025 Sepsis, a life-threatening condition caused by a dysregulated response to infection, is linked to high in-hospital mortality and healthcare costs. Survivors face increased risks of hospital readmission, cardiovascular disease, cognitive impairment, and long-term healthcare expenses. While previous reviews have examined initial hospitalisation costs and healthcare use post-sepsis, no systematic re...

Educational Strategies for Supervision of AI Use In ICU Tue, 26 Aug 2025 Recent advances in medical Artificial Intelligence (AI), especially large language models (LLMs), have transformed human-computer interactions in healthcare by simulating human-like reasoning, which could fundamentally change medical learning and practice. While AI offers educational benefits such as enhanced learning and cognitive off-loading of routine tasks, it also poses risks...

Predicting Patient Deterioration with AI  In ICU Mon, 18 Aug 2025 Accurate recognition of patient deterioration has long been a cornerstone of safe and effective hospital care. The structured recording of vital signs dates back to the 19th century and was strengthened by the introduction of the National Early Warning Score (NEWS) in the United Kingdom in 2012, later updated to NEWS2 in 2017. This scoring system standardised responses to acute illn...

Personalised Temperature Management Post-Cardiac Arrest In ICU Wed, 20 Aug 2025 Out-of-hospital cardiac arrest (OHCA) affects over 300,000 people annually and remains a major public health issue. Survival and recovery after cardiac arrest (CA) largely depend on restoring circulation and minimising brain injury from ischaemia and reperfusion following return of spontaneous circulation (ROSC). Early trials showed benefits of therapeutic hypothermia (TH) ...

Editorial  Postoperative Transfusion in Patients at High Cardiac Risk: Evidence, Uncertainty, and Nuance Jeremy W. Jacobs, Evan M. Bloch JAMA Published Online: November 8, 2025 doi: 10.1001/jama.2025.21559 For 3 decades, randomized trials have provided evidence for and steadily moved practice toward restrictive red blood cell (RBC) transfusion strategies (ie, transfusing at hemoglobin thresholds of 7-8 g/dL instead of 9-10 g/dL).1-3 With rare exception...

Critical Care Ultrasonography in the Management of Cardiogenic Shock In ICU Wed, 20 Aug 2025 Despite recent advances, mortality in cardiogenic shock (CS) remains very high. Early diagnosis and proper management are crucial, especially given shifts in CS causes, from fewer myocardial ischaemia cases to more acute decompensated heart failure. The establishment of a consensus CS definition has improved clinical and research communication.  Critica...

ditorial  A-E-I-O-U and Sometimes Why—Dialysis in Acute Kidney Injury Sushrut S. Waikar JAMA Published Online: November 7, 2025 doi: 10.1001/jama.2025.21618 Students memorize the indications for dialysis in acute kidney injury (AKI) as the vowels of the alphabet, A-E-I-O-U: acidosis, electrolytes, ingestions, overload, and uremia. In a study published in JAMA, Liu and colleagues1 ask clinicians to consider the last vowel, sometimes Y (“why”), in their ...

Status Asthmaticus: The Art of Ventilating In ICU Thu, 24 Jul 2025 ICU Management & Practice, Volume 25 - Issue 3, 2025 Recognising the mechanisms of air trapping that cause status asthmaticus can help optimise the setting of invasive mechanical ventilation. This article provides an academic visual summary to facilitate understanding. Introduction Status asthmaticus can be life-threatening. Invasive mechanical ventilation is one of the therape...

ditorial  Divergent GFR Estimates and Clinical Implications Menaka Sarav, Robert J. Alpert JAMA Published Online: November 7, 2025 doi: 10.1001/jama.2025.14043 Chronic kidney disease (CKD) affects more than 800 million people worldwide, significantly increasing the risk for kidney failure, cardiovascular disease, and all-cause mortality.1 Accurate assessment of glomerular filtration rate (GFR) is essential for identifying and managing CKD. Although GFR...