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Editorials Convalescent plasma is ineffective for covid-19 Elizabeth B Pathak BMJ 2020; 371:m4072 doi: https://doi.org/10.1136/bmj.m4072  Lessons from the Placid Trial Convalescent plasma generated great enthusiasm in the earliest days of the coronavirus disease 2019 (covid-19) pandemic because of a plausible mechanism of action,1 its 100 year history of use in the treatment of other infectious diseases,2 and rapid availability from voluntary dono...
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ICU Management & Practice, Volume 20 - Issue 3, 2020 Unmasking the Triumphs, Tragedies, and Opportunities of the COVID-19 Pandemic The COVID-19 pandemic has resulted in many changes to society and the practice of critical care medicine. Perhaps now is the time to address deficiencies in communication and decision-making that impact quality of care provided to older patients with serious illness. The COVID-19 pandemic has created a juxtaposition of triump...
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ICU Management & Practice, Volume 20 - Issue 3, 2020 Nutritional Management of the Critically Ill Older Adult A review of available evidence and an overview of recommendations for the nutritional management of the critically ill older adult. Introduction Worldwide, there is a shift in the distribution of the population towards older ages. This shift is similarly being experienced in the Intensive Care Unit (ICU), with the median age of the entire ICU ...
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COVID-19: Still Poorly Understood During the first few months of the coronavirus disease, it was being suggested that severe COVID-19 may represent a hyperimmune disorder, similar to secondary haemophagocytic lymphohistiocytosis (sHLH) and macrophage activation syndrome (MAS). Cytokine storm, elevated plasma levels, ferritin and inflammatory biomarkers are all typical signs of sHLH/MAS. But in many severe cases, T cells were found to be decreased, indicating T cell lym...
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Corticosteroids and Mortality in COVID-19 Patients The use of corticosteroids to treat severe infections has been a controversy for quite a long time. Now, as we face the COVID-19 pandemic, clinical research on corticosteroids has received a significant push. During the first six months of 2020, 55 studies of corticosteroids for the treatment of COVID-19 have been registered. The RECOVERY trial has reported its findings demonstrating that 6mg/d of dexamethasone resu...
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Epidemic Preparedness and Rapid Identification of Pathogens In recent years, infectious disease outbreaks have occurred with increasing frequency. Even though significant progress has been made to identify potentially dangerous pathogens, a lot still needs to be done. In particular,  diagnostics can play an important role in controlling epidemics. There is a need to develop and deploy diagnostics that can identify pathogens quickly and accurately. Diagnostic tests that...
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News Covid-19: Comparing Sweden’s response with the UK’s is “misleading,” experts argue Gareth Iacobucci BMJ 2020; 370: m3765 doi: https://doi.org/10.1136/bmj.m3765 Sweden’s response to covid-19 should not be used to argue the case for a population immunity strategy in the UK, the Independent Scientific Advisory Group for Emergencies (Independent SAGE) has argued. In a briefing paper published on 25 September, Independent SAGE noted that Sweden is often use...
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Perspective Rethinking Covid-19 Test Sensitivity — A Strategy for Containment Michael J. Mina, Roy Parker, and Daniel B. Larremore N Engl J Med September 30, 2020DOI: 10.1056/NEJMp2025631 It’s time to change how we think about the sensitivity of testing for Covid-19. The Food and Drug Administration (FDA) and the scientific community are currently almost exclusively focused on test sensitivity, a measure of how well an individual assay can detect viral protein...
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COVID-19 and readjusting clinical trials The COVID-19 pandemic has disrupted clinical trials worldwide, with long-lasting effects on medical science. Aaron van Dorn reports. Lancet 2020; 396: 523-524 The COVID-19 pandemic has disrupted clinical trials worldwide, with long-lasting effects on medical science. Aaron van Dorn reports.The COVID-19 pandemic has created massive disruptions to clinical trial research across the world. As in other aspects of life, the vir...
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COVID-19: Lessons to Learn from Public Discourse Regarding Hydroxychloroquine The COVID-19 pandemic has affected all aspects of our lives, including the economy, healthcare and scientific research. In the race to find effective and safe treatment for coronavirus disease, there has been a significant increase in scientific communication. However, the quality of this communication remains questionable. Preprints are not  peer-reviewed even though they are being...
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