EDITORIAL Promising Leads in Preventing Early-Onset Pneumonia After Out-Of-Hospital Cardiac Arrest Stéphane Legriel Chest 2025; 169: 3-5 DOI: 10.1016/j.chest.2025.09.123 Initial hospital treatment of patients in post-anoxic coma relies on a multifaceted approach. This encompasses the identification and treatment of the underlying cause(s) of cardiac arrest, with a focus on prevention of its reoccurrence, a consideration of post-resuscitation syndr...

Redefining Rate Control Strategy With Landiolol: Manage the Rhythm Without Compromising the System In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 Landiolol, an ultra-short-acting and highly β1-selective intravenous β-blocker, addresses the need for rapid and controllable arrhythmia suppression while maintaining cardiovascular stability. Recently approved in the United States and already in use in Europe, landiolol combi...

Biomarkers and Point-of-Care Innovation in the Emergency Department In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 Biomarkers are essential tools in the emergency department for improving early detection, risk stratification, and patient management. This article reviews challenges in biomarker integration, the diagnostic and prognostic value of pancreatic stone protein (PSP), and the role of point-of-care solutions...

Music-Listening Intervention & Delirium/Coma-Free Days in Patients Undergoing Mechanical Ventilation In ICU Thu, 16 Oct 2025 A multi-centre randomised controlled trial of critically ill adults aged 50 years and older admitted to ICUs found that twice-daily slow-tempo music (60–80 beats per minute) did not reduce the duration or severity of delirium or coma, nor did it lessen pain or anxiety compared with a silence-track control. While the interv...

Immune Dysregulation Framework for Sepsis and Critical IllnessesIn SepsisThu, 2 Oct 2025 When a critically ill patient arrives in the emergency department, physicians must make rapid, high-stakes decisions related to infection and whether that infection is bacterial or viral. There are decisions related to whether the patient needs immediate treatment, and whether they can recover safely at home or must be admitted.  Even once an infection is identified, tr...

Blood Transcriptomic Framework for Sepsis In Sepsis Wed, 8 Oct 2025 For decades, progress in developing new treatments for critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and trauma has been stalled by one fundamental challenge: although these conditions are treated as single diseases, every patient’s body responds differently. This heterogeneity has been a major barrier to advancing care. Two new studies now confront ...

Models of Post-ICU Clinics In ICU Wed, 8 Oct 2025 Advances in critical care have shifted the focus from survival alone to enhancing long-term recovery and quality of life for patients and their families. Post-Intensive Care Syndrome (PICS) encompasses persistent physical, cognitive, and psychological problems that emerge after critical illness. To address these issues, several supportive strategies have been developed, including nurse navigators, pulmo...

Medical News  Research of the Year 2025 Jennifer Abbasi; Samantha Anderer; Rita Rubin, et al JAMA Published Online: December 12, 2025 doi: 10.1001/jama.2025.20503 For this inaugural Research of the Year roundup, JAMA Medical News asked the journal’s top editors to nominate their favorite studies published in JAMA over the past year—the articles that they thought were the most impactful, the most newsworthy, ...

Digital Twins to Assess VILI Risk in APRV vs PCV In ICU Wed, 8 Oct 2025 Airway pressure release ventilation (APRV) delivers continuous positive airway pressure with periodic releases to facilitate CO₂ removal. It has been proposed both as an early intervention to reduce ventilator-induced lung injury (VILI) and as a rescue strategy for acute respiratory distress syndrome (ARDS). APRV may improve lung homogeneity, alveolar recruitment, and gas exchange,...

Multimodal CT Predicts AKI Risk in Pneumonia Sepsis  In Imaging Wed, 1 Oct 2025 Sepsis frequently results in acute kidney injury, prolonging hospital stay and increasing mortality risk. Incidence estimates range from 35–50% in sepsis and rise to 50–70% in intensive care. Early prediction remains difficult because current approaches rely on blood and urine tests that can be costly, variable and not always available in time for intervention. Pneumon...