High-Flow or Standard Oxygen in Acute Hypoxaemic Respiratory Failure In ICU Tue, 17 Mar 2026 Findings from the SOHO (Standard Oxygen versus High-Flow Oxygen Therapy in Acute Hypoxemic Respiratory Failure) trial were presented @ISICEM this morning. The SOHO trial compared high-flow nasal oxygen with standard oxygen therapy in adults with acute hypoxaemic respiratory failure. The study addresses an important clinical question: oxygen therapy is the fi...

EDITORIAL The COBRRA Trial — Ending the Venous Thromboembolism Safety Toss-up Lisa K. Moores N Engl J Med 2026;394:1123-1124 DOI: 10.1056/NEJMe2600525 The landscape of treatment options for venous thromboembolism was transformed by the arrival of direct oral anticoagulants. Large-scale trials showed that the direct oral anticoagulants apixaban and rivaroxaban were noninferior to vitamin K antagonists in terms of efficacy and had a better safety profile. How...

Editorial  Physical Restraint Use in Critical Care: Balancing Safety and Harm Kimberley J. Haines, Maj-Brit Nørregaard Kjær, Adam M. Deane JAMA Published Online: March 17, 2026 doi: 10.1001/jama.2026.2785 I was already fighting so much, not only for my life, but just like the need for a drop of water and any basic human need was being taken away anyway and then not to have the use of your bodily parts, your hands to hug somebody, to wipe away tears, t...

Short-Term Capacity Planning in an Intensive Care Unit: Web-Based Prediction Model and Pilot Study In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 ICU occupancy varies and cannot be scheduled. To tailor nurse staffing to variable ICU occupancy would potentially decrease both under- and over-staffing. We developed a simple web-based interface for short-term prediction of occupancy and, in a pilot study, compared predicted...

Bedside Monitoring of Respiratory Effort in Patients Undergoing Assisted Mechanical Ventilation In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 This review explores bedside methods for monitoring respiratory effort in patients undergoing assisted mechanical ventilation. It highlights the risks of lung and diaphragm injury from excessive or insufficient patient effort, reviews invasive and non-invasive pressure-based tech...

EDITORIAL Large Language Models as Item Writer: Innovation or Limitation? Are We Ready to Hand Over the Pen? Abdullah Alismail Chest 2025; 168: 1286-1287 The use of large language models and artificial intelligence (AI) in medical education has recently increased, not only among students, but also among faculty. Students use these tools to enhance their learning ability and comprehension of the subject, and faculty cite other reasons such as assisting them wit...

Using Recovery Rooms (PACUs) Differently: Addressing the Hidden Pandemic In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 There is increasing interest in extending PACU-based care in order to better address the growing problem of early postoperative complications and their impact on patient and hospital outcomes. There is promising evidence of benefit in this approach, but still a great deal to be learned, such as the opt...

EDITORIAL Promising Leads in Preventing Early-Onset Pneumonia After Out-Of-Hospital Cardiac Arrest Stéphane Legriel Chest 2025; 169: 3-5 DOI: 10.1016/j.chest.2025.09.123 Initial hospital treatment of patients in post-anoxic coma relies on a multifaceted approach. This encompasses the identification and treatment of the underlying cause(s) of cardiac arrest, with a focus on prevention of its reoccurrence, a consideration of post-resuscitation syndr...

Redefining Rate Control Strategy With Landiolol: Manage the Rhythm Without Compromising the System In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 Landiolol, an ultra-short-acting and highly β1-selective intravenous β-blocker, addresses the need for rapid and controllable arrhythmia suppression while maintaining cardiovascular stability. Recently approved in the United States and already in use in Europe, landiolol combi...

Biomarkers and Point-of-Care Innovation in the Emergency Department In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 Biomarkers are essential tools in the emergency department for improving early detection, risk stratification, and patient management. This article reviews challenges in biomarker integration, the diagnostic and prognostic value of pancreatic stone protein (PSP), and the role of point-of-care solutions...