Pulmonary Haemodynamic Trajectories in ECMO-Supported ARDS In ICU Wed, 4 Mar 2026 A recent study investigated the prevalence, determinants, and prognostic implications of pulmonary hypertension (PH) in patients with acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO). PH, defined as a mean pulmonary artery pressure (mPAP) greater than 20 mmHg, is a recognised complication of ARDS and cont...

Invited Commentary  The Mechanics of Improving Compliance Meghan C. O’Leary, Jessica R. Schumacher, Gita N. Mody JAMA Surg Published Online: April 15, 2026 doi: 10.1001/jamasurg.2026.0897 We were pleased to read the report by Chan et al1 about an American College of Surgeons national quality improvement (QI) collaborative. The Lung Nodal, Operative, Dissection, Evaluation, and Staging (NODES) initiative involved a collection of multilevel interventions...

Albumin Replacement Therapy in Septic Shock In Sepsis Wed, 4 Mar 2026 The Albumin Replacement Therapy in Septic Shock (ARISS) trial, published in JAMA Network Open was designed to determine whether albumin replacement improves survival in patients with septic shock. The study was conducted on behalf of the SepNet Critical Care Trials Group and ARISS investigators. Albumin is a natural colloid with physiological roles extending beyond maintenance of ...

Integrating Circadian Medicine in Critical Care A structured roadmap for integrating circadian medicine into critical care was developed during a five-day international workshop held at the Lorentz Center in Leiden, The Netherlands. Circadian rhythms, self-sustained approximately 24-hour physiological cycles regulated by a central clock in the suprachiasmatic nucleus and peripheral clocks throughout the body, are fundamental to human health. In the ICU, however, th...

EDITORIAL Selective Digestive Decontamination — Finding the Way Forward Michael Klompas N Engl J Med 2026;394:1543-1545 DOI: 10.1056/NEJMe2602823 In critical care, selective digestive decontamination (SDD) is the elephant in the room. Cluster-randomized trials, individually randomized trials, and meta-analyses have shown that the use of SDD is associated with a decreased risk of ventilator-associated pneumonia, of hospital-onset bacteremia, and in some stud...

NIVPredict: AI Tool for Early Prediction of NIV Outcome in Acute Respiratory Failure In ICU Tue, 17 Feb 2026 Patients with acute respiratory failure (ARF) who fail non-invasive ventilation (NIV) and subsequently require intubation face a significantly elevated risk of death. No formal clinical guidelines currently exist to assist clinicians in identifying which patients are most likely to fail NIV in a timely manner. Existing clinical scoring tools, in...

EDITORIAL Glucocorticoids in Kawasaki Disease — Refining Indications and the Science Jane C. Burns, Jane W. Newburger N Engl J Med 2026;394:1542-1543 DOI: 10.1056/NEJMe2518759 Kawasaki disease is the most common cause of acquired heart disease in children in the developed world.1 Although Kawasaki disease manifests with acute, transient systemic signs, its long-term morbidity derives from necrotizing vasculitis that predominantly affects the coronary a...

EDITORIAL Prehospital Whole Blood for Traumatic Hemorrhage — Consistent Evidence from Two Randomized Trial Susan E. Rowell, Selwyn O. Rogers, Jr. N Engl J Med 2026;394:2372-2373 DOI: 10.1056/NEJMe2605735 Hemorrhagic shock remains the leading cause of preventable death after injury.1 Over the past two decades, early administration of blood products has transformed care for patients with bleeding. The Pragmatic, Randomized Optimal Platelet and Plasma Rat...

Editorial  Residual Myths in Feeding Critically Ill Children Kaitlin Berris, Srinivas Murthy JAMA Published Online: June 12, 2026 doi: 10.1001/jama.2026.10505 When children become critically ill and need invasive mechanical ventilation, making sure that they get the right amount of nutritional support is crucial, not only for the physiologic needs of delivering appropriate amounts of calories and protein, but also for the needs of the family, where fee...

Effect of Respiratory Training on Lung Function in ICU Patients In ICU Tue, 10 Feb 2026 A recent review evaluated the effects of respiratory muscle training (RMT) on lung function and mechanical ventilation outcomes in adult patients. The authors address a clinically important issue: mechanically ventilated patients frequently develop respiratory muscle weakness and diaphragmatic atrophy due to prolonged disuse, sedation and neuromuscular blockade, whi...