Editorial  Surveillance of Sepsis in Children—Making Every Case Count Luregn J. Schlapbach, Shu-Ling Chong, Nora Luethi JAMA Published Online: March 22, 2026 doi: 10.1001/jama.2026.2814 Sepsis is a leading cause of hospital admissions, mortality, and health care expenditure worldwide. It disproportionally affects very young and very old individuals. Sepsis in young individuals carries a magnified societal impact through potential years of life lost and...

INSPIRE: Anakinra Treatment for Reducing Organ Dysfunction in Pneumonia  In ICU Wed, 28 Jan 2026 A recent article reports the INSPIRE trial, a study evaluating whether a precision immunotherapy strategy using the interleukin-1 (IL-1) receptor antagonist anakinra can prevent progression to organ dysfunction and death in adults hospitalised with community-acquired or hospital-acquired pneumonia who are identified as high risk by elevated presepsin l...

Targeted Tissue Perfusion vs Macrocirculatory-Guided Standard Care in Septic Shock In Sepsis Wed, 28 Jan 2026 The TARTARE-2S trial investigated whether a haemodynamic strategy focused on improving tissue perfusion while permitting lower-than-recommended mean arterial pressure (MAP) could improve outcomes in patients with septic shock compared with conventional MAP-guided standard care. Current sepsis guidelines prioritise maintaining MAP targets, typic...

Suspension-Based Lower-Limb Rehabilitation for ICU-Acquired Weakness In ICU Wed, 21 Jan 2026 A recent trial evaluated the short-term efficacy of a suspension-based lower-limb rehabilitation device (SS) in patients with intensive care unit–acquired weakness (ICUAW). ICUAW is a frequent and serious complication of critical illness, characterised by symmetrical limb weakness, prolonged mechanical ventilation, functional impairment, and reduced quality of ...

Invasive & Non-Invasive Monitoring of Inspiratory Effort & Drive in Assisted Mechanical Ventilation In ICU Wed, 21 Jan 2026 A clinical review examined the invasive and non-invasive monitoring of inspiratory effort and respiratory drive in patients undergoing assisted mechanical ventilation (AMV). Following the acute phase of respiratory failure, AMV is commonly used to support spontaneous breathing, improve gas exchange, and reduce sedation req...

Invited Commentary  Infectious Diseases Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis? Nathan C. Bahr, Radha Rajasingham, David R. Boulware JAMA Netw Open 2026;9;(1):e2553489. doi:10.1001/jamanetworkopen.2025.53489 Cryptococcal meningitis remains a life-threatening opportunistic infection among people with advanced HIV, even in high-resource settings. For decades, the standard induction regimen in the United State...

Acute Respiratory Distress Syndrome Molecular Phenotypes In ICU Wed, 21 Jan 2026 A new study investigated whether the two well-established molecular phenotypes of acute respiratory distress syndrome (ARDS)—hyperinflammatory and hypoinflammatory—are associated with distinct biological processes in the lung. Although these phenotypes were originally defined using plasma biomarkers and clinical variables and are known to differ in prognosis and treatment ...

ICU Dashboard Tracks Environmental Impact In ICU Tue, 13 Jan 2026 Green initiatives in Intensive Care Units (ICUs) increasingly focus on reducing the environmental footprint of routine care. Common measures include lowering glove use, replacing absorption pads with towels and shifting from disposable clothing to washable alternatives. While such actions are relatively simple to introduce, sustaining them requires structured monitoring. ICU teams need r...

Poetry and Medicine  28 Hours in the ICU Kaveh Danesh JAMA Published Online: March 11, 2026 doi: 10.1001/jama.2026.0660 I watch the sunrise I watch the sunset I watch the body fall apart while we tilt the horizon away from light knowing the sun setting in the West is rising in the East. I watch the sunrise I watch the sunrise I watch your pupils suspended midday between two horizons. [JAMA编者按]：ICU中的...

Redefining Sepsis Through Host–Microbe Dynamics In Sepsis Thu, 15 Jan 2026 Current approaches to classifying sepsis are limited because they rely too heavily on clinical features and host-only immune responses, while largely ignoring the role of the infecting microbes. Sepsis is a heterogeneous syndrome, and grouping patients based on clinical signs alone assumes a single underlying mechanism, which is often incorrect. This has hindered progress in und...