Invited Commentary  Health Informatics Limitations of Large Language Models in Clinical Diagnostic Reasoning Mickael Tordjman, Xueyan Mei JAMA Netw Open 2026;9;(4):e264014. doi:10.1001/jamanetworkopen.2026.4014 Large language models (LLMs) have rapidly gained an important role in multiple fields, including medicine. These widely available tools can enhance patient understanding, improve physician productivity, and provide encyclopedic knowledge on seve...

Editorial  Prone Positioning in Viral Bronchiolitis—Back to the Back? Joseph G. Kohne, Susan R. Conway, Steven L. Shein JAMA 2026;336;(4):290-292. doi:10.1001/jama.2026.11742 Acute viral bronchiolitis is the most common diagnosis in US children’s hospitals, and respiratory failure is the costliest diagnosis across all pediatric acute care.1 Despite the prevalence of this condition and its impact on children, families, and health systems, evidence-based tr...

Invited Commentary  Emergency Medicine Is Poor Recognition of Out-of-Hospital Cardiac Arrest to Blame for Worse Rates of Survival at Night? Sarah M. Perman JAMA Netw Open 2026;9;(4):e269837. doi:10.1001/jamanetworkopen.2026.9837 Emergency care is a 24 hours-a-day, 7 days-a-week, and 365 days-a-year operation. Those of us in emergency medicine, prehospital medicine, and acute critical care staff departments and agencies care for any patient with...

Global Mortality Patterns Shift as COVID-19 Recedes  In ICU Mon, 3 Nov 2025 Regular, comparable assessments of causes of death help set health priorities. Updated estimates now cover 292 causes across 204 countries and territories, plus 660 subnational locations, for each year from 1990 to 2023. The analysis combines death counts, rates and years of life lost (YLLs) and adds two intuitive measures: the probability of dying before age 70 ...

Comment Real-time subphenotyping in acute respiratory distress syndrome: a step towards precision medicine Denise Battaglini, Marcus J Schultz, Patricia R M Rocco The Lancet Respiratory Medicine, Available online 23 March 2026 https://doi.org/10.1016/S2213-2600(26)00054-8 Acute respiratory distress syndrome (ARDS) has long been defined by pragmatic clinical criteria that favour sensitivity over biological specificity. This strategy has enabled early recognitio...

Reducing Diagnostic Errors in Critical Illness  In ICU Fri, 31 Oct 2025 Accurate diagnosis underpins safe and effective critical care, yet the diagnostic process in acute illness is inherently vulnerable. Time pressure, evolving physiology and limited patient history often converge when illness is most severe. Critical illness is also encountered beyond intensive care units (ICUs) and in some cases follows earlier diagnostic missteps that escalate...

Optimal Timing of Anticoagulation After Ischaemic Stroke and Atrial Fibrillation In ICU Wed, 25 Jun 2025 Atrial fibrillation (AF) accounts for about 20–30% of ischaemic strokes. Direct oral anticoagulants (DOACs) are very effective for long-term secondary prevention of ischaemic stroke in AF patients, reducing the risk of intracranial haemorrhage by about half compared to vitamin K antagonists. However, the best timing to start anticoagulation after an...

Viewpoint  AI in Medicine Artificial Intelligence Is Not the End of the Physician Canio Martinelli, Vincenzo Carnevale, Alfredo Ercoli, et al JAMA Published Online: April 29, 2026 doi: 10.1001/jama.2026.4356 No one predicted that artificial intelligence (AI) would first surpass physicians on empathy—diagnostic accuracy, perhaps; imaging interpretation, certainly. Empathy was supposed to be the last refuge...

#LIVES2025: Proactive vs Reactive Treatment of Hypotension During Surgery  In ICU Tue, 28 Oct 2025 Intraoperative hypotension affects over 75% of surgical patients and is linked to serious complications, including myocardial ischaemia, kidney failure, and death. Despite this prevalence, uncertainty remains about optimal blood pressure management during surgery.  The PRETREAT (Proactive vs Reactive Treatment of Hypo...

EDITORIAL Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir H. Clifford Lane, Anthony S. Fauci N Engl J Med 2026;394:1649-1650 DOI: 10.1056/NEJMe2603127 The first cases of Covid-19 were reported at the end of 2019, and from January 20, 2020, to May 5, 2023, Covid-19 was considered to be a public health emergency of international concern. The total number of cases worldwide exceeded 1 million by early April 2020. In the United ...