EDITORIAL Effect of Oxygen Therapy on Mortality in the ICU Paul J. Young N Engl J Med 2021; 384:1361-1363DOI: 10.1056/NEJMe2101538 Oxygen therapy is a key component of supportive care for patients who have hypoxemic respiratory failure and are being treated in the intensive care unit (ICU). Yet, although oxygen can be lifesaving for patients with severe hypoxemia, overzealous oxygen administration may be harmful. Furthermore, data to inform the use of oxygen t...

COMMENT| VOLUME 397, ISSUE 10285, P1599-1601, MAY 01, 2021 Tocilizumab in COVID-19: some clarity amid controversy Shruti Gupta, David E Leaf Lancet 2021; 397: 1599-1601 Hyperactivation of the immune response, including release of pro-inflammatory cytokines such as interleukin-6 (IL-6), might play a key role in the pathophysiology of severe illness from COVID-19.1Consistent with this notion, one of the few therapies that reduces mortality in hosp...

CORRESPONDENCE|ONLINE FIRST Guidelines should not pool evidence from uncomplicated and severe COVID-19 Nicholas J White, Nathalie Strub-Wourgaft, Abul Faiz, Philippe J Guerin Lancet Published: March 22, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00469-4 The WHO Global Development Group guidelines on COVID-19 therapeutics are meant to provide evidence-based advice to all countries on the medical management of patients with COVID-19.1, 2The only smal...

ICU Management & Practice, Volume 21 - Issue 1, 2021 Important Questions Answered During the question/answer session, Prof Vito Marco Ranieri discussed some important questions with Prof Salvatore Maurizio Maggiore and Prof Boris Jung regarding sedation regimen, respiratory muscle paralysis, sedation in COVID-19 patients specifically and how it is different from other regular ICU patients. Ranieri: What is your opinion on deep sedation using remifentanil...

ICU Management & Practice, Volume 21 - Issue 1, 2021 How Should We Manage Sedation in Critically-Ill COVID-19 Patients? Clinical Practice Guidelines The Choosing Wisely top five guidelines published a few years ago by the Chest Association of Physicians, the American Thoracic Society, the Society of Critical Care Medicine, and the American Association of Critical Care Nurses state that mechanically ventilated patients should not be deeply sedated without...

Editorial March 25, 2021 Respiratory Support During the COVID-19 PandemicIs It Time to Consider Using a Helmet? Laveena Munshi, Jesse B. Hall JAMA. Published online March 25, 2021. doi:10.1001/jama.2021.4975 Acute hypoxemic respiratory failure (AHRF) is the most common organ failure and cause of admission to the intensive care unit (ICU) among patients with COVID-19. As with all forms of AHRF, ICU management is supportive while treating the unde...

ICU Management & Practice, Volume 21 - Issue 1, 2021 Why Do We Need Sedation in Critically-Ill COVID-19 Patients? COVID-19 patients present to the hospital with lung involvement and interstitial pneumonia eventually associated with lung collapse. The clinical picture is dominated by severe hypoxaemia without dyspnoea/tachypneoa and normal respiratory mechanics; this condition has been defined as silent hypoxia. The picture may evolve, and these patients may...

ICU Management & Practice, Volume 21 - Issue 1, 2021 Rethinking Critical Care - Use and Challenges of Artificial Intelligence Why digitalisation of intensive care medicine means less rather than more data Intensive Care Medicine is generating an amount of data that is hardly analysable by humans. Digitalising and using artificial intelligence has to focus on providing less rather than more data. Introduction - AI in Intensive Care Medicine: Ghost or G...

ICU Management & Practice, Volume 21 - Issue 1, 2021 How the Pandemic Changed Telemedicine An overview of the large-scale transition to telemedicine at Mayo Clinic during the COVID-19 pandemic and how it happened in a matter of days and represented one of the most rapid transformations of healthcare in history. Impact of the Pandemic on Society The 2019 Coronavirus Disease (COVID-19) pandemic has affected nearly all aspects of society, from family int...

ICU Management & Practice, Volume 21 - Issue 1, 2021 Prone Position in Awake, Non-Intubated Patients with ARDS: From Physiology to the Bedside Prone position (PP) in awake, non-intubated patients with respiratory failure is a physiology-based ventilatory strategy that improves oxygenation and may decrease the need for intubation and invasive mechanical ventilation (IMV). Introduction During the pandemic caused by the SARS-CoV-2 virus, which produces c...