COMMENT|ONLINE FIRST Time to knock monoclonal antibodies off the platform for patients hospitalised with COVID-19 Adrienne E Shapiro, Rachel A Bender Ignacio Lancet Infect Dis Published:December 23, 2021 DOI:https://doi.org/10.1016/S1473-3099(21)00762-3 The research community has responded to the COVID-19 pandemic with innovative platform trials to address the need for rapid evaluation of novel agents using a common protocol, among them being RECOVERY,1&nbs...

2030: Projections for the Emergency Medicine Physician Workforce Over the last few decades, the emergency physician workforce has undergone a dramatic transformation. There was a time when most physicians working in the emergency department had not completed residency training in emergency medicine. This began around 1970. Today, there are 273 emergency medicine residences accredited by the Accreditation Council for Graduation Medical Education (ACGME). While em...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP Oxygen therapy and mechanical ventilation in patients with COVID-19 and steps to choose the right therapeutic strategy for each patient. Introduction Severe acute respiratory syndrome coronavirus CoV-2 is the highly contagious viral agent responsible for the ongoing COVID-19 pandemic. COVID-19 is the name of the syndrome caused by SARS-C...

Association Between Age and Neurological Outcomes in OHCA There is very little information about the differences in outcomes between young and old patients who receive extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA). In this study, researchers aimed to investigate the differences in outcomes between patients aged 75 years and older and patients younger than 75 years. All patients included in the analysis were those w...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Airway Management in Critically Ill Patients – Striving to Improve Outcomes Tracheal intubation in critically ill patients requires planning, preparation and optimisation of patient’s physiology prior to the procedure. Reducing repeated attempts at tracheal intubation, improving peri-intubation oxygenation, and haemodynamic optimisation, are some of the steps that can reduce the antecedent morbidity and m...

ICU Management & Practice, Volume 20 - Issue 3, 2020 Angiotensin II in Post Cardiopulmonary Bypass Vasoplegia - The Experience So Far Post cardiopulmonary bypass vasoplegia is common, and associated with poor outcomes. Traditional management strategies involving escalating doses of catecholamines, vasopressin and adjuncts such as methylene blue and hydroxycobalamin or ascorbic acid have not shown promising results. Since ACE enzyme dysfunction, high serum r...

ICU Management & Practice, Volume 21 - Issue 4, 2021 Women in Critical Care An overview of gender inequity in critical care medicine, why there is limited progress towards gender equity in this particular specialty, barriers to women’s progress and possible solutions. The United Nations Educational, Scientific and Cultural Organization have delineated the difference between two entities - equality and equity as “Gender equality, does not mean that w...

EDITORIAL Molnupiravir — A Step toward Orally Bioavailable Therapies for Covid-19 Richard Whitley N Engl J Med 2022; 386:592-593DOI: 10.1056/NEJMe2117814 The Covid-19 pandemic has resulted in substantial global morbidity and mortality as well as disruption of the economies of virtually every country.1 Some of this tragedy could have been averted with the development of deliverable, orally bioavailable, direct-acting antiviral therapeutics. Molnupiravir, t...

ICU Management & Practice, Volume 21 - Issue 4, 2021 Sex in the Intensive Care Change content default valueSex interplays with the development of several diseases and syndromes, impacting differently the need for intensive care unit admission between men and women. All in all, men are more prone to develop critical illness than women, which explains their over-representation in the intensive care unit. On the other hand, treatments differ between men and wo...

ICU Management & Practice, Volume 21 - Issue 4, 2021 Male Sex - An Independent Risk Factor for Mortality in Very Old Intensive Care Patients Among 1,841 very old ICU patients with respiratory failure, although women had higher age and frailty, males had higher 30-day mortality assessed one month after ICU admission. Particularly in light of the ongoing pandemic, male patients appear to be at significantly higher risk for worse outcomes than females. Intr...