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ORIGINAL ARTICLE Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age C. Buddy Creech, Evan Anderson, Vladimir Berthaud, et al N Engl J Med May 11, 2022DOI: 10.1056/NEJMoa2203315 Abstract BACKGROUND Vaccination of children to prevent coronavirus disease 2019 (Covid-19) is an urgent public health need. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children 6 to 11 years of age are unknown. METHODS Part 1 o...
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EDITORIAL Does the World Still Need New Covid-19 Vaccines? Hanna Nohynek, Annelies Wilder-Smith N Engl J Med May 4, 2022DOI: 10.1056/NEJMe2204695 Although there was a global shortage of Covid-19 vaccines in 2021, by mid 2022, the vaccine supply will no longer be a limiting factor in efforts to provide more equitable coverage. As of April 19, 2022, approximately 11.5 billion Covid-19 vaccine doses have been administered globally.1 Scaling up manufacturing ...
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ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Lasting Legacy in Intensive Care Medicine Catheter dressingsBuetti N., Rickard C.M. and Timsit J-F. Critical care ultrasoundWong A., Robba C. and Mayo P. Prone position in mechanically ventilated patientsPapazian L., Munshi L. and Guérin C. OriginalNicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trialLabro G. et al. Pa...
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ORIGINAL ARTICLE Effect of Early Treatment with Ivermectin among Patients with Covid-19 Gilmar Reis, Eduardo A.S.M. Silva, Daniela C.M. Silva, et al N Engl J Med March 30, 2022DOI: 10.1056/NEJMoa2115869 Abstract BACKGROUND The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syn...
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ORIGINAL ARTICLE Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine Edson D. Moreira, Jr., Nicholas Kitchin, Xia Xu, et al N Engl J Med March 23, 2022DOI: 10.1056/NEJMoa2200674 Abstract BACKGROUND Active immunization with the BNT162b2 vaccine (Pfizer–BioNTech) has been a critical mitigation tool against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the coronavirus disease 2019 (Covid-19) pandemic. In light of...
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ORIGINAL Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double‑blind randomised controlled trial Lu Ke, Jing Zhou, Wenjian Mao, et al Intensive Care Med 2022 Jun 17. doi: 10.1007/s00134-022-06745-7. Online ahead of print. Abstract Purpose: Infected pancreatic necrosis (IPN) is a highly morbid complication of acute necrotising pancreatitis (ANP). Since there is evidence of early-onset immunosuppress...
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传统观点认为,由于液体丢失和血管扩张,感染性休克患者可出现循环容量的绝对和相对不足,因此,积极的液体复苏是纠正循环功能障碍和(或)组织低灌注的重要手段[1]。然而,近年来的研究提示,液体正平衡或容量负荷过多是包括感染性休克在内的重症患者不良预后甚至死亡的独立危险因素[2]。基于这些发现,限制性液体(复苏)治疗成为感染性休克临床研究的热点问题。 刚刚在线发表的CLASSIC研究旨在评价限制静脉液体对ICU中感染性休克患者的病死率及其他重要预后指标的影响[3]。这是一项前瞻随机对照试验,在8个...
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ORIGINAL ARTICLE Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine Karen J. Hager, Gonzalo Pérez Marc, Philipe Gobeil, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2201300 Abstract BACKGROUND Coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are combined with an adjuvant (Adjuvant ...
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EDITORIAL Monoclonal Antibodies with Extended Half-Life to Prevent Covid-19 Jonathan Abraham N Engl J Med 2022; 386:2236-2238DOI: 10.1056/NEJMe2205563 Early treatment (i.e., soon after the onset of Covid-19 symptoms) with monoclonal antibodies that target the SARS-CoV-2 spike protein reduces the risks of Covid-19–related hospitalization and death.1-3 Yet, despite the success of these interventions, in response to continued pressure from human immune respo...
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ORIGINAL ARTICLE Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis Joseph N. Jarvis, David S. Lawrence, David B. Meya, et al N Engl J Med 2022; 386:1109-1120DOI: 10.1056/NEJMoa2111904 Abstract BACKGROUND Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious i...
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