EDITORIAL Glucocorticoids in Kawasaki Disease — Refining Indications and the Science Jane C. Burns, Jane W. Newburger N Engl J Med 2026;394:1542-1543 DOI: 10.1056/NEJMe2518759 Kawasaki disease is the most common cause of acquired heart disease in children in the developed world.1 Although Kawasaki disease manifests with acute, transient systemic signs, its long-term morbidity derives from necrotizing vasculitis that predominantly affects the coronary a...

ORIGINAL ARTICLE Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group N Engl J Med 2026;394:2329-2339 DOI: 10.1056/NEJMoa2506905 Abstract BACKGROUND Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus&...

EDITORIAL Prehospital Whole Blood for Traumatic Hemorrhage — Consistent Evidence from Two Randomized Trial Susan E. Rowell, Selwyn O. Rogers, Jr. N Engl J Med 2026;394:2372-2373 DOI: 10.1056/NEJMe2605735 Hemorrhagic shock remains the leading cause of preventable death after injury.1 Over the past two decades, early administration of blood products has transformed care for patients with bleeding. The Pragmatic, Randomized Optimal Platelet and Plasma Rat...

Original Investigation  An American College of Surgeons National Quality Improvement Collaborative to Enhance Lung Cancer Surgical Quality Kelley Chan, Eileen M. Reilly, Ryan C. Jacobs, et al JAMA Surg Published Online: April 15, 2026 doi: 10.1001/jamasurg.2026.0902 Key Points Question  Can a national quality improvement (QI) collaborative model increase compliance for a lung cancer operative standard? Findings  Among 354 accr...

ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS Understanding the Disease Cardiac output and determinantsBhattacharjee, S., Ferrer, R. & Hamzaoui, O. LATEST ARTICLES Editorial Defining ECMO complications: a step towards improving clinical outcomes?Brown, A., Barbaro, R. Update on long-term physical disability after critical illness: the burden of post-intensive care syndromeHermann, M., Karner, V. & Schaller, S.J. Immunosuppressiv...

Original Investigation  Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial Major Extremity Trauma Research Consortium (METRC) JAMA Published online: April 15, 2026 doi: 10.1001/jama.2026.4023 Key Points Question  Is the combination of intrawound tobramycin and vancomycin powder more effective than vancomycin powder alone to reduce deep surgical site infection in...

Editorial  Residual Myths in Feeding Critically Ill Children Kaitlin Berris, Srinivas Murthy JAMA Published Online: June 12, 2026 doi: 10.1001/jama.2026.10505 When children become critically ill and need invasive mechanical ventilation, making sure that they get the right amount of nutritional support is crucial, not only for the physiologic needs of delivering appropriate amounts of calories and protein, but also for the needs of the family, where fee...

ORIGINAL ARTICLE Selective Decontamination of the Digestive Tract in Adult Mechanically Ventilated Patients — An Updated Systematic Review with Bayesian Meta-Analysis Naomi E. Hammond, Anthony Devaux, Ruan Vlok, et al NEJM Evidence Published April 15, 2026 DOI: 10.1056/EVIDoa2500264 Abstract BACKGROUND There is uncertainty whether the use of selective decontamination of the digestive tract (SDD) as a preventive antimicrobial strategy reduces mortality...

Original Investigation  Caring for the Critically Ill Patient Gastric Residual Volume Assessment in Critically Ill Children: The GASTRIC-PICU Randomized Clinical Trial Lyvonne N. Tume, Paul R. Mouncey, Julia M. Broomhall, et al JAMA Published Online: June 12, 2026 doi: 10.1001/jama.2026.10639 Key Points Question  Is not routinely assessing gastric residual volume noninferior to regular assessment to guide enteral feeding in children wit...

ORIGINAL ARTICLE Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage Jason L. Sperry, Francis X. Guyette, Bryan A. Cotton, et al N Engl J Med 2026;394:2317-2328 DOI: 10.1056/NEJMoa2602167 Abstract BACKGROUND Blood transfusion before arrival at a hospital reduces mortality from traumatic hemorrhage and shock. Whether transfusion with whole blood is more beneficial than transfusion with blood components is uncertain, as are the e...