CORRESPONDENCE| VOLUME 7, ISSUE 10, PE31, OCTOBER 01, 2019 Secondary re-analysis of the FEAST trial – Authors' reply Michael Levin, Aubrey J Cunnington, Clive J Hoggart Lancet Respir Med 2019; 7: e31 DOI:https://doi.org/10.1016/S2213-2600(19)30264-4 Kathyrn Maitland and colleagues have voiced concerns about the difference between findings in our re-analysis of the FEAST trial1 and their 2013 report2 on which one of us (ML) was also an author. T...

#LIVES2019: Vitamin C for Sepsis Dr. Alpha A. Fowler of Virginia Commonwealth University presented findings from the CITRIS-ALI trial that studied the role of vitamin C in patients with septic ARDS. The findings were presented @ESICM in Berlin and have just been published in JAMA. The CITRIS-ALI randomised trial addressed the use of high dose intravenous vitamin C to study the effects of organ failure and the effects of vitamin C on inflammation and vascular inj...

CORRESPONDENCE| VOLUME 7, ISSUE 10, OCTOBER 01, 2019 Secondary re-analysis of the FEAST trial Kathryn Maitland, Diana M Gibb, Abdel Babiker Lancet Respir Med 2019; 7: e29 DOI:https://doi.org/10.1016/S2213-2600(19)30272-3 The article by Michael Levin and colleagues1 rekindles the discussion about adverse effects of boluses in children with febrile illness and shock, as reported in the FEAST trial.2 However, unfortunately, results of this re-analysis of FEAST da...

#LIVES2019: Findings from the TOPMAST Study In an interesting session at #LIVES2019, Dr. Niels Van Regenmortel from Antwerp University Hospital, Belgium, presented findings from the TOPMAST trial. The TOPMAST study was conducted to determine the effects of sodium content of maintenance fluid therapy on cumulative fluid balance and electrolyte disorders. Dr. Van Regenmortel started off his presentation by discussing five inconvenient truths of recognition that in...

ARTICLES| VOLUME 7, ISSUE 7, P581-593, JULY 01, 2019 Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial Michael Levin, Aubrey J Cunnington, Clare Wilson, et al Lancet Respir Med 2019; 7: 581-593 DOI:https://doi.org/10.1016/S2213-2600(19)30114-6 Background 背景 Fluid resuscitation is the recommended management of shock, but increased mortality in febrile African children in the FEAST trial. ...

ORIGINAL ARTICLE Conservative Oxygen Therapy during Mechanical Ventilation in the ICU The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med October 14, 2019DOI: 10.1056/NEJMoa1903297 BACKGROUND 背景 Patients who are undergoing mechanical ventilation in the intensive care unit (ICU) often receive a high fraction of inspired oxygen (Fio2) and have a high arterial oxygen tension. The conservative...

COMMENT| VOLUME 7, ISSUE 10, P830-831, OCTOBER 01, 2019 A new frontier in ARDS trials: phenotyping before randomisation Carolyn M Hendrickson, Carolyn S Calfee Lancet Respir Med 2019; 7: 830-831 DOI:https://doi.org/10.1016/S2213-2600(19)30175-4 Despite decades of progress in both the experimental understanding of acute respiratory distress syndrome (ARDS) and in preclinical studies identifying potentially effective new treatments, most clinical ...

Editorial October 2, 2019 A Measured Dose of Optimism for the Evolution of ICU-Based Palliative Care Christopher E. Cox, MD, May Hua, David Casarett JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.12660 Ideally, palliative care is involved early in the course of illness, and usually in the outpatient setting. With this model of care, the treatment provided is guided by shared decision-making that includes the patient’s voice and a ...

Editorial October 1, 2019 Is High-Dose Vitamin C Beneficial for Patients With Sepsis? Emily B. Brant, Derek C. Angus JAMA. 2019;322(13):1257-1258. doi:10.1001/jama.2019.11643 For centuries, scurvy was the scourge of naval exploration. Then, in 1747, in arguably the first clinical trial, James Lind assigned sailors sick with scurvy to alternative acid treatments, and noted that those who received citrus fruits, as sources of ascorbic acid (vitami...

Editorial October 2, 2019 Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients Irene Telias, Niall D. Ferguson JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14609 Liberating patients from ongoing invasive mechanical ventilation is typically a 3-step process. First, clinicians must recognize that patients may no longer require mechanical ventilation—ie, when the reasons...