COVID-19: Therapies Targeting Interleukin-6-Mediated Cytokine Release Syndrome The current pandemic will be remembered for a long time for the huge loss of lives and disruption it caused to the way of life as we know it. In the absence of a viable vaccine, physical distancing and symptomatic management are the only interventions health care providers have at hand. Studies have demonstrated the association of interleukin-6 (IL-6)-mediated cytokine release syndrome and m...

Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial ABSTRACT Background 背景 Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (COVID-19) on the basis of in vitro activity, uncontrolled data, and small randomized studies. 根据体外活性，非对照研究数据以及小样本随机试验，羟氯喹和氯喹被用于治疗新冠病毒感染(COVID-19)。 Methods 方...

COVID-19: Risk Score to Predict Critical Illness The coronavirus disease (COVID 19) continues to create havoc around the globe. Millions of people have been infected with the virus and thousands have died. The infection is spread via droplet particles. Many infected patients remain asymptomatic; others develop a mild upper respiratory infection-like illness and some develop a serious lung infection that requires admission to the ICU. COVID-19 cases that are of a severe...

Is COVID-19 Pneumonia ARDS or Not? COVID-19 pneumonia meets the ARDS Berlin definition. However, it is a specific disease with peculiar phenotypes. The primary characteristic is the dissociation between the severity of the hypoxaemia and the maintenance of respiratory mechanics. Patients with respiratory compliance that is lower or higher than the median value experience severe hypoxaemia. In a recent editorial published in Critical Care, the authors propose ...

ORIGINAL ARTICLE FREE PREVIEW Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury The STARRT-AKI Investigators for the Canadian Critical Care Trials Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group, the United Kingdom Critical Care Research Group, the Canadian Nephrology Trials Network, and the Irish Critical Care Trials Group N Engl J Med 2020; 383:240-251DOI: 10.1056/NEJMoa2000741 Abstract BACKGR...

COVID-19: Quarantine Measures, Laws and Limits COVID-19 continues to spread, and governments across the globe have imposed quarantines and travel bans. China locked down its cities, Italy imposed restrictions throughout the country, and the US and Canada have enforced self-quarantine. The US has banned the entry of travellers from China, Iran, and most of Europe, while many other countries have implemented heavy screening protocols. However, despite these quarantine me...

ARTICLES|ONLINE FIRST Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study Anna Coppo, Giacomo Bellani, Dario Winterton, et al Lancet Respir Med Published:June 19, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30268-X Summary Background The COVID-19 pandemic is challenging advanced health systems, which are dealing with an overwhelming...

Hospitals’ Creative Responses to Coronavirus Challenges While hospitals around the world are struggling to fight the COVID-19 pandemic with limited or unavailable supplies and equipment, some are forced to become creative and find new ways to continue care delivery and, at the same time, protect the staff. One-Person Booths South Korea has already proven the effectiveness of its rigorous testing policies. Of over 8,500 confirmed cases only slightly above 1% ...

ICU Management & Practice, Volume 20 - Issue 1, 2020 COVID-19: Masks in Intensive Care Units With the number of COVID-19 cases increasing in the intensive care units, there is a high risk of infection for healthcare professionals. What kind of masks can be used and what are the most effective strategies to protect against airborne particles? Currently, there is an increasing number of patients in the intensive care units (ICUs) due to COVID-19 all over t...

ORIGINAL ARTICLE Effect on Patient Safety of a Resident Physician Schedule without 24-Hour Shifts Christopher P. Landrigan, Shadab A. Rahman, Jason P. Sullivan, et al N Engl J Med 2020; 382:2514-2523DOI: 10.1056/NEJMoa1900669 Abstract BACKGROUND The effects on patient safety of eliminating extended-duration work shifts for resident physicians remain controversial. METHODS We conducted a multicenter, cluster-randomized, crossover trial comparing two...