ICU Management & Practice, Volume 18 - Issue 4, 2018 Clinical assessment of critically ill patients by whole-body ultrasonography In this article we focus on the evidence of whole-body ultrasonography used for hypotension or shock. We first highlight individual ultrasound components in association to hypotension and shock. Second, we provide an outline of current literature on whole-body ultrasonography, its effect on outcome, and try to integrate the previ...

ORIGINAL ARTICLE Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm Jean-Baptiste Lascarrou, Hamid Merdji, Amélie Le Gouge, et al N Engl J Med October 2, 2019DOI: 10.1056/NEJMoa1906661 BACKGROUND 背景 Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate therapeutic hypothermia i...

ICU Management & Practice, Volume 17 - Issue 4, 2017 Molecular diagnostics in severe respiratory virus infection Recent trends in virus detection assays and host response biomarkers This article provides an overview of the recent advances in molecular testing for patients with suspected respiratory tract infection. Respiratory tract infections are common reasons for admission to intensive care units. For decades conventional culture techniques were th...

CORRESPONDENCE| VOLUME 7, ISSUE 10, PE31, OCTOBER 01, 2019 Secondary re-analysis of the FEAST trial – Authors' reply Michael Levin, Aubrey J Cunnington, Clive J Hoggart Lancet Respir Med 2019; 7: e31 DOI:https://doi.org/10.1016/S2213-2600(19)30264-4 Kathyrn Maitland and colleagues have voiced concerns about the difference between findings in our re-analysis of the FEAST trial1 and their 2013 report2 on which one of us (ML) was also an author. T...

#LIVES2019: Vitamin C for Sepsis Dr. Alpha A. Fowler of Virginia Commonwealth University presented findings from the CITRIS-ALI trial that studied the role of vitamin C in patients with septic ARDS. The findings were presented @ESICM in Berlin and have just been published in JAMA. The CITRIS-ALI randomised trial addressed the use of high dose intravenous vitamin C to study the effects of organ failure and the effects of vitamin C on inflammation and vascular inj...

CORRESPONDENCE| VOLUME 7, ISSUE 10, OCTOBER 01, 2019 Secondary re-analysis of the FEAST trial Kathryn Maitland, Diana M Gibb, Abdel Babiker Lancet Respir Med 2019; 7: e29 DOI:https://doi.org/10.1016/S2213-2600(19)30272-3 The article by Michael Levin and colleagues1 rekindles the discussion about adverse effects of boluses in children with febrile illness and shock, as reported in the FEAST trial.2 However, unfortunately, results of this re-analysis of FEAST da...

#LIVES2019: Findings from the TOPMAST Study In an interesting session at #LIVES2019, Dr. Niels Van Regenmortel from Antwerp University Hospital, Belgium, presented findings from the TOPMAST trial. The TOPMAST study was conducted to determine the effects of sodium content of maintenance fluid therapy on cumulative fluid balance and electrolyte disorders. Dr. Van Regenmortel started off his presentation by discussing five inconvenient truths of recognition that in...

ARTICLES| VOLUME 7, ISSUE 7, P581-593, JULY 01, 2019 Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial Michael Levin, Aubrey J Cunnington, Clare Wilson, et al Lancet Respir Med 2019; 7: 581-593 DOI:https://doi.org/10.1016/S2213-2600(19)30114-6 Background 背景 Fluid resuscitation is the recommended management of shock, but increased mortality in febrile African children in the FEAST trial. ...

ORIGINAL ARTICLE Conservative Oxygen Therapy during Mechanical Ventilation in the ICU The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med October 14, 2019DOI: 10.1056/NEJMoa1903297 BACKGROUND 背景 Patients who are undergoing mechanical ventilation in the intensive care unit (ICU) often receive a high fraction of inspired oxygen (Fio2) and have a high arterial oxygen tension. The conservative...

COMMENT| VOLUME 7, ISSUE 10, P830-831, OCTOBER 01, 2019 A new frontier in ARDS trials: phenotyping before randomisation Carolyn M Hendrickson, Carolyn S Calfee Lancet Respir Med 2019; 7: 830-831 DOI:https://doi.org/10.1016/S2213-2600(19)30175-4 Despite decades of progress in both the experimental understanding of acute respiratory distress syndrome (ARDS) and in preclinical studies identifying potentially effective new treatments, most clinical ...