COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study Jessica J Manson, Colin Crooks, Meena Naja, et al Lancet Rheumatol Published:August 21, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30275-7 Summary Background 背景 A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-1...

Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic Hallie C. Prescott, ToddW. Rice JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.16747 Corticosteroids, such as hydrocortisone and dexamethasone, have anti-inflammatory, antifibrotic, and vasoconstrictive effects, which intensivists have been trying to leverage for decades to improve outcomes in patients with acute respiratory distress syndrome (ARDS) and septic shock. In the f...

ARTICLES| VOLUME 20, ISSUE 4, P425-434, APRIL 01, 2020 Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Heshui Shi, Xiaoyu Han, Nanchuan Jiang, et al Lancet Infect Dis 2020; 20: 425-434 Summary 摘要 Background 背景 A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuh...

COMMENT|ONLINE FIRST ECMO for severe ARDS associated with COVID-19: now we know we can, but should we? Kiran Shekar, Arthur S Slutsky, Daniel Brodie JAMA Published:August 13, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30357-X The initial months of the COVID-19 pandemic were dominated by studies reporting poor and varied outcomes in patients who developed severe acute respiratory distress syndrome (ARDS) associated with the disease. Variable mortality could...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Sleep Deprivation and Fatigue Management in the Intensive Care Unit The impact of sleep deprivation and fatigue on patients and staff in the intensive care unit and how improved sleep, reduced noise disturbances, and more organised shifts could be beneficial for both patients and clinicians. The World Health Organization (WHO) recommends that average daily sound levels in patient care areas should be a...

Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study Matthieu Schmidt, David Hajage, Guillaume Lebreton Lancet Respir Med Published:August 13, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30328-3 Summary 摘要 Background 背景 Patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and...

Original Investigation September 8, 2020 Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury Susan E. Rowell, Eric N. Meier, Barbara McKnight, et al JAMA. 2020;324(10):961-974. doi:10.1001/jama.2020.8958 Abstract 摘要 Importance 背景 Traumatic brain injury (TBI) is the leading cause of death and disability due to trauma. Early administrati...

ORIGINAL ARTICLE FREE PREVIEW High-Flow Oxygen with Capping or Suctioning for Tracheostomy Decannulation Gonzalo Hernández Martínez, Maria-Luisa Rodriguez, Maria-Concepción Vaquero, et al N Engl J Med 2020; 383:1009-1017DOI: 10.1056/NEJMoa2010834 Abstract 摘要 BACKGROUND 背景 When patients with a tracheostomy tube reach a stage in their care at which decannulation appears to be possible, it is common practice to cap the tracheostomy tube for 24 hour...

Original Investigation Caring for the Critically Ill PatientSeptember 2, 2020 Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial The Writing Committee for the REMAP-CAP Investigators JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17022 Abstract Importance Evidence regarding corticosteroid use for severe coronavirus...

Original Investigation Caring for the Critically Ill PatientSeptember 2, 2020 Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial Bruno M. Tomazini, Israel S. Maia, Alexandre B. Cavalcanti, et al JAMA. Published online September 2, 2020. doi:10.1001/jama.2020.17021 Abstract Importance Acute respiratory distress sy...