ARTICLES|ONLINE FIRST Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial Remo H M Furtado, Otavio Berwanger, Henrique A Fonseca, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31862-6 Summary 摘要 Background 背景 The efficacy and safety of azithromycin in the treatmen...

ARTICLES|ONLINE FIRST Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial Toby Richards, Ravishankar Rao Baikady, Ben Clevenger, et al Lancet Published:September 04, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31539-7 Summary 摘要 Background 背景 Preoperative anaemia affects a high proportion of patients undergoing major elective surgery and is associated with poor outc...

COVID-19 and readjusting clinical trials The COVID-19 pandemic has disrupted clinical trials worldwide, with long-lasting effects on medical science. Aaron van Dorn reports. Lancet 2020; 396: 523-524 The COVID-19 pandemic has disrupted clinical trials worldwide, with long-lasting effects on medical science. Aaron van Dorn reports.The COVID-19 pandemic has created massive disruptions to clinical trial research across the world. As in other aspects of life, the vir...

HealthManagement, Volume 20 - Issue 5, 2020 COVID-19 Antibody Testing – Why it Matters and Factors to Consider As we move into the next phase of the COVID-19 pandemic, there will be a need to test a broad strata of population, much more than what molecular tests can handle. The solution lies with serological tests. As the world continues the fight against COVID-19, healthcare executives are in an uncomfortable position – having to make critical decisions wit...

PulmCrit – Splitting ventilators to provide titrated support to a large group of patients March 15, 2020 by Josh Farkas COVID-19 might out-strip the number of mechanical ventilators available to us.  This has led to interest in using a single ventilator to support multiple patients.  This post will review the theory and evidence regarding this (with the admission that I don’t have experience with this).  basic principles Bedrock principle: ...

COVID-19: Lessons to Learn from Public Discourse Regarding Hydroxychloroquine The COVID-19 pandemic has affected all aspects of our lives, including the economy, healthcare and scientific research. In the race to find effective and safe treatment for coronavirus disease, there has been a significant increase in scientific communication. However, the quality of this communication remains questionable. Preprints are not  peer-reviewed even though they are being...

PulmCrit – Awake Proning for COVID-19 May 5, 2020 by Josh Farkas Recently, many on twitter have been engaged in a furious debate about how to ventilate patients with COVID-19.  Is it ARDS or not?  High PEEP or low PEEP?…  As an intensivist, these issues are near and dear to my heart.  However, the truth is that humble methods to keep patients off invasive ventilation altogether are probably more important.  One such technique is awake pronin...

ARTICLES|ONLINE FIRST Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study Richard Kuehl, Laura Morata, Christian Boeing, et al Lancet Infect Dis Published:August 04, 2020 DOI:https://doi.org/10.1016/S1473-3099(20)30447-3 Summary 摘要 Background 背景 Staphylococcus aureus persistent bacteraemia is only vaguely defined and the effect of different durations of bacteraemia on mortality is not well establish...

HealthManagement, Volume 20 - Issue 6, 2020 Improved Patient Assessment with MR-proADM Prof. Carlo Tascini is Head of Infectious Diseases Clinic at Udine University Hospital. Prior to that, he was the Head of First Division of Infectious Diseases Unit at Cotugno Hospital. His field of interests include endocarditis, meningitis, sepsis, MDR bacterial infection and fungal infections. HealthManagement.org spoke to Prof. Tascini about the clinical benefits of MR-pr...

ICU Management & Practice, Volume 20 - Issue 2, 2020 Is COVID-19 the Black Swan? Nassim Taleb, in his book, "The Black Swan: The Impact of the Highly Improbable," describes the term Black Swan as a rare, unknown event, which with hindsight is rationalised. Taleb talks about the human tendency to always find simplistic explanations for unknown events, what he calls the Black Swan theory. Is COVID-19 a black swan? Introduction Physicians working with cr...