End-Tidal CO2 Levels vs. Arterial CO2 Levels in Children with TBI For patients with Traumatic Brain Injury (TBI), the partial pressure of CO2, arterial (PaCO2) can be adjusted to help with the regulation of cerebral perfusion. However, this can prove difficult to carry out in children. The non-invasive method of capnography measures end-tidal CO2 (EtCO2) and is often used for paediatric patients as an alternative to arterial cannulation. EtCO2 measurements have ...

Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial David R Janz, Jonathan D Casey, Matthew W Semler, et al Lancet Respir Med. 2019 Oct 1. doi: 10.1016/S2213-2600(19)30246-2 Background 背景 Tracheal intubation is common in the care of critically ill adults and is frequently complicated by hypotension, cardiac arrest, or death. We aimed to evaluate ...

Machine-Learning-Based Prediction Models for AKI Acute Kidney Injury (AKI) is a common occurrence for critically ill patients in the ICU, and its early diagnosis has proven to be challenging. The accuracy of the online, machine-learning-based prediction model, AKIpredictor, was analysed for its use in a clinical setting. The study, which took place over five ICUs in Belgium, compared the predictions of AKIpredictor with physician predictions. The patient informa...

Editorial October 21, 2019 Should Fibrinogen Concentrate Replace Cryoprecipitate in Cardiac Surgery? Aaron S. Hess, John R. Hess, Douglas B. Coursin JAMA. Published online October 21, 2019. doi:10.1001/jama.2019.17313 Excessive bleeding presents a critical medical challenge. Many of the problems encountered at the bedside, such as inadequate measures of coagulation, challenges in delivering blood components, uncertain role of prothrombotic drugs...

ONLINE FIRST (FREE ACCESS) What's new in intensive care ~ Lüsebrink E. et al. - Ten things ICU specialists need to know about new valvular procedures in interventional cardiology Less is more in Intensive Care ~ Ñamendys-Silva S.A - Less is more, but are we doing enough?Editorial ~ Shankar-Hari M. et al. - Should we consider blocking the inhibitory immune checkpoint molecules for treating T cell exhaustion in sepsis?Original ...

Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP): A Phase II, Multicenter, Randomized, Controlled Trial Hodgson CL, Cooper DJ, Arabi Y, et al Am J Respir Crit Care Med. 2019 Jul 29.doi: 10.1164/rccm.201901-0109OC. RATIONALE: 背景 Open lung ventilation strategies have been recommended in patients with acute respiratory distress syndrome (ARDS). 推荐ARDS患者采用肺开放通气策略。 OBJECTIVE: 目的 To determine ...

Emergency Department to ICU Time and Mortality Delays in transferring patients from the Emergency Department (ED) to the ICU could delay treatment, leaving the patient at risk. A recent study explored the impact of this and found that increased ED to ICU wait times were associated with increased hospital mortality. Data was used from the Dutch quality registry National Intensive Care Evaluation, covering 14,788 patients admitted to the ICU through the ED from 2009 ...

ARTICLES|ONLINE FIRST Effect of infectious disease consultation on mortality and treatment of patients with candida bloodstream infections: a retrospective, cohort study Carlos Mejia-Chew, Jane A O'Halloran, Margaret A Olsen, et al. Lancet Infect Dis September 24, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30405-0 Summary Background 背景 Candida bloodstream infection is associated with high mortality. Infectious disease consultation improves outcomes...

Original Investigation Mobile Photoplethysmographic Technology to Detect Atrial Fibrillation Guo Y, Wang H, Zhang H, et al J Am Coll Cardiol. 2019 Nov 12;74(19):2365-2375. doi: 10.1016/j.jacc.2019.08.019 Background Low detection and nonadherence are major problems in current management approaches for patients with suspected atrial fibrillation (AF). Mobile health devices may enable earlier AF detection and improved AF management. Objectives This study...

Research Methods & Reporting A guide to prospective meta-analysis Anna Lene Seidler, Kylie E Hunter, Saskia Cheyne, et al BMJ 2019; 367: l5342 DOI:https://doi.org/10.1136/bmj.l5342 Summary points In a prospective meta-analysis (PMA), studies are identified and determined to be eligible for inclusion before the results of the studies related to the PMA research question are knownPMAs are applicable to high priority research questions where limited previo...