ORIGINAL ARTICLE Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 John H. Stone, Matthew J. Frigault, Naomi J. Serling-Boyd, et al N Engl J Med October 21, 2020DOI: 10.1056/NEJMoa2028836 BACKGROUND The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. METHODS We performed a randomized, double-blind, placebo-controlled tria...

Corticosteroids and Mortality in COVID-19 Patients The use of corticosteroids to treat severe infections has been a controversy for quite a long time. Now, as we face the COVID-19 pandemic, clinical research on corticosteroids has received a significant push. During the first six months of 2020, 55 studies of corticosteroids for the treatment of COVID-19 have been registered. The RECOVERY trial has reported its findings demonstrating that 6mg/d of dexamethasone resu...

ARTICLES|ONLINE FIRST Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:October 05, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)32013-4 Summary 摘要 Background 背景 Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies. Here, we repo...

ONLINE FIRST THIS WEEK(FREE ACCESS) Narrative Review ~ Logan C. et al. - Invasive candidiasis in critical care: challenges and future directions Correspondence ~ Bouhemad B.  et al. - Left ventricular diastolic dysfunction as a predictor of weaning failure from mechanical ventilation. Author’s reply Editorial ~ Finkenstedt A. et al. - Stress ulcer prophylaxis: Is mortality a useful endpoint? ...

ARTICLES| VOLUME 20, ISSUE 9, P1025-1033, SEPTEMBER 01, 2020 Individual quarantine versus active monitoring of contacts for the mitigation of COVID-19: a modelling study Corey M Peak, Rebecca Kahn, Yonatan H Grad, et al Lancet Infect Dis 2020; 20: 1025-1033 Summary Background Voluntary individual quarantine and voluntary active monitoring of contacts are core disease control strategies for emerging infectious diseases such as COVID-19. Given the impact o...

Epidemic Preparedness and Rapid Identification of Pathogens In recent years, infectious disease outbreaks have occurred with increasing frequency. Even though significant progress has been made to identify potentially dangerous pathogens, a lot still needs to be done. In particular,  diagnostics can play an important role in controlling epidemics. There is a need to develop and deploy diagnostics that can identify pathogens quickly and accurately. Diagnostic tests that...

News Covid-19: Comparing Sweden’s response with the UK’s is “misleading,” experts argue Gareth Iacobucci BMJ 2020; 370: m3765 doi: https://doi.org/10.1136/bmj.m3765 Sweden’s response to covid-19 should not be used to argue the case for a population immunity strategy in the UK, the Independent Scientific Advisory Group for Emergencies (Independent SAGE) has argued. In a briefing paper published on 25 September, Independent SAGE noted that Sweden is often use...

ICU Management & Practice, Volume 20 - Issue 3, 2020 Promising Techniques in Sepsis After Cardiac Surgery The purpose of this article is to give an up-to-date, comprehensive review on the utilisation of extracorporeal blood purification techniques and immunostimulation in septic patients after cardiac surgery. Introduction Sepsis is a potentially life-threatening state caused by an infection and an inadequate, dysregulated host immune response. In gen...

Perspective Rethinking Covid-19 Test Sensitivity — A Strategy for Containment Michael J. Mina, Roy Parker, and Daniel B. Larremore N Engl J Med September 30, 2020DOI: 10.1056/NEJMp2025631 It’s time to change how we think about the sensitivity of testing for Covid-19. The Food and Drug Administration (FDA) and the scientific community are currently almost exclusively focused on test sensitivity, a measure of how well an individual assay can detect viral protein...

2020 most popular articles in Critical Care Featured Reviews  Biomarkers in critical care nutrition The goal of nutrition support is to provide the substrates required to match the bioenergetic needs of the patient and promote the net synthesis of macromolecules required for the preservation of lean mass, organ function, and immunity. Optimization of nutrition delivery should thus improve ICU clinical outcomes. C. Stoppe et al. discuss the development of...