COVID-19: Neurological Associations The most common manifestation of COVID-19 has been respiratory illness with a growing recognition of neurological sequelae. In this recent review, researchers take into consideration the neurological features of COVID-19 and summarise the evidence available to suggest an investigation framework to guide future studies.  Before COVID-19, there were six other coronaviruses known to infect humans and cause respiratory pathology....

What is the Relevance of Cytokine Storm to COVID-19? COVID-19, in its most severe form, leads to life-threatening pneumonia and acute respiratory distress syndrome (ARDS). In patients with this severity of the coronavirus, mortality rate can approach 40 to 50%.  The mechanism of COVID-19 induced lung injury is still vague, but the term cytokine storm is being used quite frequently in scientific publications as well as the media. What is this cytokine storm and ...

COVID-19 and Acute Kidney Injury Incidence and risk factors for acute kidney injury (AKI) in COVID-19 patients Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5449 hospitalized COVID-19 patients, AKI was observed primarily in patients with respiratory failure, with AKI developing in 89.7% of patients on mechanical ventilation compared ...

ARTICLES| VOLUME 396, ISSUE 10245, P177-185, JULY 18, 2020 Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial Alparslan Turan, Andra Duncan, Steve Leung, et al Lancet Published:July 18, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30631-0 Summary Background Atrial fibrillation and delirium are common consequences of cardiac surgery. Dexmedetomidine has unique propertie...

Pulmonary Pathobiology of COVID-19 The primary cause of death with COVID-19 is progressive respiratory failure. However, despite the widespread infection rates associated with COVID, very little is known about the pathophysiology of the disease. What clinicians do know is that the pathological features resemble acute respiratory distress syndrome (ARDS) and progressive hypoxia. But the underlying molecular and biochemical alterations caused by the virus still remain un...

ARTICLES| VOLUME 396, ISSUE 10245, P167-176, JULY 18, 2020 Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial Nicolien J Schepers, Nora D L Hallensleben, Marc G Besselink, et al Lancet Published:July 18, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30539-0 Summary Background It remains un...

ICU Management & Practice, Volume 20 - Issue 1, 2020 Intensive Care in the Coronavirus Era: Keep in Mind Your Collective Intelligence Above and beyond the logistical and organisational aspects, shaken by the COVID-19 pandemic, here is an overview of our experience as an intensive care team in Switzerland. We will not parade the efficient measures implemented in our institution in preparation for welcoming COVID-19 patients; rather, we will discuss the im...

ICU Management & Practice, Volume 20 - Issue 1, 2020 A COVID-19 Dashboard: Data Analytics to Aid Resource Allocation in Intensive Care Units In this article, we focus on clinical and practical application of current available cloud-based data analysis to track and benchmark in real-time suspect and confirmed COVID-19 cases, resource use and availability. Introduction The COVID-19 pandemic represents an unprecedented challenge to intensive care units (...

Original Investigation July 28, 2020 Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial Alparslan Turan, Hani Essber,Wael Saasouh, et al JAMA. 2020;324(4):350-358. doi:10.1001/jama.2020.10009 Abstract Importance 背景 Opioid-induced ventilatory depression and hypoxemia is common, severe, and often unrecognized in postoperative patients. To the extent that nonopioid an...

ICU Management & Practice, Volume 20 - Issue 1, 2020 Nutrition for Critically Ill Patients with COVID-19 This article discusses the nutritional implications for critically ill patients admitted to intensive care for the management of COVID-19, and considers the inflammatory metabolic processes, nutrition-impacting symptoms, medical therapy, and the impact of a pandemic on staff resourcing and remote practice. Introduction The global pandemic caused by...