Original Investigation January 19, 2021 Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial Renato D. Lopes, Ariane V. S. Macedo, Pedro G. M. de Barros E Silva, et al JAMA. 2021;325(3):254-264. doi:10.1001/jama.2020.25864 Abstract Importance It is unknown whether angiotensin-c...

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial  RECOVERY Collaborative Group Lancet 2021; 397: 605–12  https://doi.org/10.1016/ S0140-6736(21)00149-5  Summary  Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID...

Original Investigation January 19, 2021 Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial Wenjie Zi, Zhongming Qiu, Fengli Li, et al JAMA. 2021;325(3):234-243. doi:10.1001/jama.2020.23523 Abstract Importance For patients with large vessel occlusion strokes, it is unknown whether endovascular treatm...

Original Investigation Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children Naïm Ouldali, MD, Julie Toubiana, Denise Antona, et al JAMA. Published online February 1, 2021. doi:10.1001/jama.2021.0694 Abstract Importance Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with severe acute respirator...

Original Investigation January 19, 2021 Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial Kentaro Suzuki, Yuji Matsumaru, Masataka Takeuchi, et al JAMA. 2021;325(3):244-253. doi:10.1001/jama.2020.23522 Abstract Importance Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy in patien...

Original Investigation Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial Gregory Ducrocq, Jose R. Gonzalez-Juanatey, Etienne Puymirat, et al JAMA. 2021;325(6):552-560. doi:10.1001/jama.2021.0135 Abstract Importance The optimal transfusion strategy in patients with acute myocardial infarction and anemia is unclear. ...

Original Investigation January 12, 2021 Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest: A Randomized Clinical Trial Francis Kim, Charles Maynard, Cameron Dezfulian, et al JAMA. 2021;325(2):138-145. doi:10.1001/jama.2020.24326 Abstract Importance Therapeutic delivery of sodium nitrite during resuscitation improved survival in animal models of cardiac arrest, but efficacy has not been evaluate...

ORIGINAL ARTICLE Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults Romina Libster, Gonzalo Pérez Marc, Diego Wappner, et al N Engl J Med January 6, 2021DOI: 10.1056/NEJMoa2033700 Abstract BACKGROUND Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be...

ARTICLES| VOLUME 397, ISSUE 10273, P499-509, FEBRUARY 06, 2021 Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial Johan A Maertens, Galia Rahav, Dong-Gun Lee, et al Lancet 2021; 397: 499-509 Summary Background Voriconazole has been recommended as primary treatment for patients with invasive aspergillosis. Intravenous and tablet formulations of posaconaz...

ORIGINAL ARTICLE Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis Christopher G. Hughes, Patrick T. Mailloux, John W. Devlin N Engl J Med February 2, 2021DOI: 10.1056/NEJMoa2024922 Abstract BACKGROUND Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation...