Original Investigation March 18, 2021 Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial INSPIRATION Investigators JAMA. Published online March 18, 2021. doi:10.1001/jama.2021.4152 Abstract Importance 背景 Thrombotic events are co...

ONLINE FIRST THIS WEEK(FREE ACCESS) Letter ~ Rousset D. et al. - Bedside ultrasound monitoring of prone position induced lung inflationCOVID-19 in Intensive Care ~ Sandroni C. et al. ~The impact of COVID-19 on the epidemiology, outcome and management of cardiac arrestConference Reports and Expert Panel ~ Domínguez-Gil B. et al. - Expanding controlled donation after the circulatory determination of death: statement from an international collaborativeCOVID-19 in Intensiv...

Research Letter March 1, 2021 Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2 Saman Saadat, Zahra Rikhtegaran Tehrani, James Logue, et al JAMA. Published online March 1, 2021. doi:10.1001/jama.2021.3341 Current shortages in COVID-19 vaccine production and distribution have led some experts to suggest untested regimens.1 Persons who have had COVID-19 are thought to ...

Original Investigation February 26, 2021 Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis Perrine Janiaud, Cathrine Axfors, MD, Andreas M. Schmitt, et al JAMA. Published online February 26, 2021. doi:10.1001/jama.2021.2747 Abstract Importance Convalescent plasma is a proposed treatment for COVID-19. Objective To assess clinical outcomes with convalesc...

ECMO, Mortality and ARDS An in-depth analysis was conducted in Germany to evaluate whether mortailty in Germany in Extracorporeal life support (ECLS) therapy differed from previously reported literature.  Extracorporeal life support (ECLS) is a critical component of intensive care therapy. There are various conditions that require the use of ECLS. The term ECLS encompasses different terms depending on the system and the type of cannulation that is used. Th...

Editorial February 17, 2021 Vitamin D3 to Treat COVID-19: Different Disease, Same Answer David E. Leaf, Adit A. Ginde JAMA. Published online February 17, 2021. doi:10.1001/jama.2020.26850 Biological activity of vitamin D and its metabolites include, among other properties, potent antimicrobial and anti-inflammatory effects in vitro.1 In animal models, administration of vitamin D metabolites attenuates a variety of acute organ dysfunction, i...

ICU Management & Practice, Volume 20 - Issue 4, 2020 Prolonged Intubation and Tracheostomy in COVID-19 Survivors Consequences and Recovery of Laryngeal Function Intubation and tracheostomy as a result of COVID-19 critical illness may result in laryngeal dysfunction, which can lead to serious consequences. This article provides assessment and rehabilitation recommendations for those working with critically ill COVID-19 patients in the ICU. Introduction...

Original Investigation February 17, 2021 Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial Igor H. Murai, Alan L. Fernandes, Lucas P. Sales, et al JAMA. Published online February 17, 2021. doi:10.1001/jama.2020.26848 Abstract Importance The efficacy of vitamin D3 supplementation in coronavirus disease 2...

[2021年1月25日，WHO在其官方网站发布了新版新冠肺炎诊疗指南。现简要介绍新版指南的改动情况，供临床医生参考] COVID-19 Clinical management: living guidance https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1 注：新版指南增加了有条件推荐(conditional recommendation)以及最佳实践声明(Best practice statement)。 筛查、分诊与临床评估：早期识别新冠肺炎患者 （有条件推荐）：对于门诊或医院评估的任何严重程度的新冠肺炎患者，我们建议根据临床判断（包括考虑到...

ORIGINAL ARTICLE A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 ACTIV-3/TICO LY-CoV555 Study Group N Engl J Med 2021; 384:905-914DOI: 10.1056/NEJMoa2033130 Abstract BACKGROUND LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effec...