Original Investigation December 7, 2021 Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial Gustavo A. Ospina-Tascón, Luis Eduardo Calderón-Tapia, Alberto F. García, et al JAMA. 2021;326(21):2161-2171. doi:10.1001/jama.2021.20714 Abstract Importance  The effect of high-flow oxygen therapy vs convention...

Editorials Public health measures for covid-19 Paul P Glasziou, Susan Michie, Atle Fretheim BMJ 2021; 375 doi: https://doi.org/10.1136/bmj.n2729 (Published 18 November 2021)Cite this as: BMJ 2021;375:n2729 Lack of good research is a pandemic tragedy Although the pandemic has seen remarkable trials for vaccines and drug treatments, much less has been done to evaluate the effects of public health and social measures (PHSMs)1; also known as non-pharmaceutical ...

Original Investigation December 7, 2021 Effect of a Diagnostic Strategy Using an Elevated and Age-Adjusted D-Dimer Threshold on Thromboembolic Events in Emergency Department Patients With Suspected Pulmonary Embolism: A Randomized Clinical Trial Yonathan Freund, Anthony Chauvin, Sonia Jimenez, et al JAMA. 2021;326(21):2141-2149. doi:10.1001/jama.2021.20750 Abstract Importance  Uncontrolled studies suggest that pulmonary embolism (PE...

Research Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis Stella Talic, Shivangi Shah, Holly Wild, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-068302 (Published 18 November 2021)Cite this as: BMJ 2021;375:e068302 Abstract Objective To review the evidence on the effectiveness of public health...

Top Stories from #ISICEM21 #ISICEM21: Advances in Resistant Gram-Negative Pneumonia In an interesting discussion at the 40th ISICEM International Symposium on Intensive Care & Emergency Medicine,  Richard Wunderink, Professor of Medicine, Pulmonary and Critical Care Division of Northwestern University’s Feinberg School of Medicine and Medical Director, Medical ICU, Northwestern Memorial Hospital, Chicago, discussed rising levels of multi-drug resistance...

ARTICLES|ONLINE FIRST Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published: November 17, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)01825-0 Summary Background Aspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate the efficacy and safety of aspirin in patients admitted ...

Practice Rapid Recommendations A living WHO guideline on drugs for covid-19 Arnav Agarwal,  Bram Rochwerg, Reed AC Siemieniuk, et al BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m3379 (Published 04 September 2020)Cite this as: BMJ 2020;370:m3379 Abstract Updates This is a living guideline. It replaces earlier versions (4 September 2020, 20 November 2020, 17 December 2020, 31 March 2021, 6 July 2021, and 23 September 2021). The previous versions ...

Medical News & Perspectives November 3, 2021 Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents Anita Slomski JAMA. Published online November 3, 2021. doi:10.1001/jama.2021.19388 In the COVID-19 pandemic’s early days, integrative medicine specialists Gordon Saxe, MD, PhD, MPH, and Andrew Shubov, MD, watched in frustration as desperate patients infected with the novel coronavirus tried one ineffective remedy after another. “People were t...

Human Connection in the Time of COVID-19 Human connection has suffered quite significantly during the COVID-19 pandemic. While physical distancing is necessary for our wellbeing, restricting family presence in the ICU has been challenging. There is recent data that show the negative consequences of these policies and restrictions. Moral distress has been reported due to restrictive family visitation policies. It is also believed that patients may be spending mor...

Original Investigation November 2, 2021 Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial Julia A. Bielicki, Wolfgang Stöhr, Sam Barratt, et al JAMA. 2021;326(17):1713-1724. doi:10.1001/jama.2021.17843 Abstract Importance  The optimal dose and duration of oral amoxicillin for children with community-acquired pn...