Not All Organ Failures Are Created Equal: Study Identifies the Sepsis Symptoms That Lead to Death By: Lauren Ingeno November 26, 2018 Using patient records from 210,289 hospital visits between 2013 and 2016, Drexel University researchers have identified the specific symptoms that put patients at the greatest risk of dying from sepsis – and they’re not what many clinicians might think. Sepsis, a life-threatening condition caused by the body’s response to an infection, i...

Phenotyping: need to identify subgroups of ARDS patients The consensus definitions of acute respiratory distress syndrome (ARDS) mainly rely on feasible clinical criteria, which help to group patients together for inclusion in clinical trials and for clinical management. This generates clinical and biological differences in observable patient characteristics. These differences could be used to group ARDS patients, referred to as ARDS subphenotypes, according to an arti...

Research Christmas 2018: Heart of the Matter Death and readmissions after hospital discharge during the December holiday period: cohort study Lauren Lapointe-Shaw, Peter C Austin, Noah M Ivers, et al. BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4481 (Published 10 December 2018) Cite this as: BMJ 2018;363:k4481 Abstract Objective 目的 To determine whether patients discharged from hospital during the Dece...

Patients with AKI and sepsis: when to initiate renal-replacement therapy Among patients with septic shock who had severe acute kidney injury (AKI), there was no significant difference in overall mortality at 90 days between patients who were assigned to an early strategy for the initiation of renal-replacement therapy and those who were assigned to a delayed strategy, according to a randomised controlled trial published in The New England Journal of Medicine. AKI is the m...

Metabolic-based biomarkers have potential to triage children with sepsis A new study has validated potential biomarkers for a sepsis-triage model to distinguish sepsis patients requiring care in the paediatric intensive care unit (PICU) from sepsis identified in the paediatric emergency department (PED) that does not require ICU admission. The study, led by Beata Mickiewicz and colleagues from the University of Calgary and University of Alberta, took serum and plasma samp...

Research Christmas 2018: Heart Of The Matter Christmas, national holidays, sport events, and time factors as triggers of acute myocardial infarction: SWEDEHEART observational study 1998-2013 Moman A Mohammad, Sofia Karlsson, Jonathan Haddad, et al BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4811 (Published 12 December 2018) Cite this as: BMJ 2018;363:k4811 Abstract 摘要 Objectives 目的 To study circadian rhythm aspects, national holidays, and...

It is time for improved fluid stewardship Prof. Manu Malbrain, MD, PhD ICU Director - Intensive Care Unit, University Hospital Brussels (UZB), Jette, Belgium Professor - Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB) Brussels, Belgium A conceptual framework for developing institutional programmes and guidelines to enhance fluid stewardship (especially in the intensive care unit [ICU] environment), an activity that includes appropriate selection, dosin...

Research Christmas 2018: Food For Thought Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study Susan B Roberts, Sai Krupa Das, Vivian Marques Miguel Suen, et al BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4864 (Published 12 December 2018) Cite this as: BMJ 2018;363:k4864 Abstract 摘要 Objective 目的 To measure the energy content of frequently ordered meal...

Blood glucose targets: time to think again? A rethink of blood glucose targets in critically ill patients is needed, according to James S. Krinsley, MD, FCCP, Department of Medicine, Stamford Hospital, writing in an editorial in Chest.Krinsley outlines the take-home points from the observational multicentre study by Hersh et al. that analysed outcomes for 1895 medical and surgical cardiac patients treated with a validated insulin administration algorithm, comparing two tar...

Research Christmas 2018: Look Before You Leap Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial Robert W Yeh, Linda R Valsdottir, Michael W Yeh, et al BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k5094 (Published 13 December 2018) Cite this as: BMJ 2018;363:k5094 Abstract Objective 目的 To determine if using a parachute prevents death or major traumati...