ICU Management & Practice, Volume 21 - Issue 3, 2021 Vasopressor Management in Septic Shock: General Overview and Personalised Approaches This article summarises the proceedings of an ESICM webinar in which two experts discuss vasopressor therapy and its fundamental role in the treatment of septic shock-induced hypotension. They provide an overview of severe septic shock, the benefits of second-line vasopressors and their use in COVID-19 patients....

Original Investigation October 11, 2021 Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial Jean M. Connors, Maria M. Brooks, Frank C. Sciurba, et al JAMA. Published online October 11, 2021. doi:10.1001/jama.2021.17272 Abstract Importance  Acutely ill inpatients with COVID-19 typically receive antithromb...

The Evolution of Cerebrovascular Critical Care The Society of Critical Care Medicine (SCCM) was founded in 1970. At that time, there was little to offer for the acute management of patients suffering from an acute cerebrovascular condition other than supportive care. Patients suffering from stroke were rarely found in the intensive care unit. During the 1960s, 25% of stroke patients would die within 24 hours. Approximately 50% would die within 2 to 3 weeks. Even...

Original Investigation October 19, 2021 Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial Michel Le May, Christina Osborne, Juan Russo, et al JAMA. 2021;326(15):1494-1503. doi:10.1001/jama.2021.15703 Abstract Importance  Comatose survivors of out-of-hospital cardiac arrest experience high rates o...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalsVariation in severity-adjusted resource use and outcome in intensive care unitsTakala J. et al. OriginalAerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up studyVan Aerde N. et al. Systematic ReviewPalliative care interventions in intensive care unit patientsMetaxa V. et al. OPEN ACCESS ~ Systematic ReviewEffect of adjunctive v...

High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial Elena Garbero, Sergio Livigni, Fiorenza Ferrari, et al Intensive Care Med Published: 03 October 2021 Abstract Purpose This study aimed at evaluating the efficacy and safety of high-dose (> 0.2 L/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic sh...

Why Intensivists Should Participate in Home Ventilation Teams A historical review of the birth of intensive care medicine and home mechanical ventilation; and an opinion piece on the merits of intensivists participating in home ventilation care teams. The world is currently reeling from the ravages of COVID-19. It is still too early to know how healthcare will be transformed as a result of this epidemic. For now, it appears that COVID-19 will leave behind large numb...

Editorial September 3, 2021 Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink Kimberly G. Blumenthal, Neelam A. Phadke, David W. Bates JAMA. 2021;326(14):1375-1377. doi:10.1001/jama.2021.14808 Vaccines represent one of the greatest public health achievements of modern medicine. They must pass rigorous and predetermined efficacy and safety metrics prior to licensure. Additionally, postmarketing safety surveillance is essenti...

ICU Management & Practice, Volume 19 - Issue 4, Winter 2019/2020 Future ICU Design: Return to High Visibility Future ICU designs must feature high visibility to ensure safety. The ability for critical care nurses, physician intensivists, and other caregivers to visualise their patients has always been a high priority as it plays a major role in patient and staff safety. Architects and designers have responded with configurations for intensive care units ...

Original Investigation October 7, 2021 Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021 Emily Jane Woo, Adamma Mba-Jonas, Rositsa B. Dimova, et al JAMA. Published online October 7, 2021. doi:10.1001/jama.2021.16496 Abstract Importance  As part of postauthorization safety surveillance, the US Food and Drug Administration (FDA) ha...