Research Christmas 2021: Time Warp Ghost in the machine or monkey with a typewriter—generating titles for Christmas research articles in The BMJ using artificial intelligence: observational study Robin Marlow, Dora Wood BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067732 (Published 15 December 2021)Cite this as: BMJ 2021;375:e067732 Abstract Objective To determine whether artificial intelligence (AI) can generate plausible and eng...

Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine Alexander P. J. Vlaar, Joanna C. Dionne, Sanne de Bruin, et al Intensive Care Medicine  2021; 47: 1368-1392 Transfusion support in massively bleeding, critically ill adults Part 1: massively bleeding patients 1. Transfusion ratios We suggest use of high-ratio transfusion strategies (at least one unit plasm...

Research Christmas 2021: Get Lucky Giving science the finger—is the second-to-fourth digit ratio (2D:4D) a biomarker of good luck? A cross sectional study James M Smoliga, Lucas K Fogaca, Jessica S Siplon, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067849 (Published 15 December 2021)Cite this as: BMJ 2021;375:e067849 Abstract Objectives To explore whether random chance, weak research methodology, or inappropriate reporting can lead ...

Early vs. Late Awake Prone Positioning in COVID-19 Approximately 25 to 30% of COVID-19 patients develop signs of acute respiratory distress that require higher respiratory support in terms of oxygen therapy, and noninvasive and invasive positive pressure ventilation. Since the beginning of the COVID-19 pandemic, the use of awake prone positioning has increased in the management of patients with COVID-19. Early prone positioning improves oxygenation and pati...

Research Christmas 2021: Trading Places Bah humbug! Association between sending Christmas cards to trial participants and trial retention: randomised study within a trial conducted simultaneously across eight host trials Elizabeth Coleman, Catherine Arundel, Laura Clark, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067742 (Published 14 December 2021)Cite this as: BMJ 2021;375:e067742 Abstract Objectives To determine the effectiveness ...

Original | Open Access | Published: 23 November 2021 Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial G. Bellingan, F. Jacono, J. Bannard-Smith, et al Intensive Care Med Abstract Purpose Bone marrow-derived, allogeneic, multipotent adult progenitor cells demonstrated safety and efficacy in preclinical models of acute re...

Simultaneous Management of ARDS and sABI Acute respiratory distress syndrome (ARDS) occurs in approximately 40% of patients with severe acute brain injury (sABI), including acute ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage and traumatic brain injury. It is also a major determinant of morbidity and mortality. With the increase in ARDS cases and reports of neurological complications in COVID-19, there is now a need to manage concomitant s...

ORIGINAL ARTICLE Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults Mark D. Neuman, Rui Feng, Jeffrey L. Carson, et al N Engl J Med 2021; 385:2025-2035DOI: 10.1056/NEJMoa2113514 Abstract BACKGROUND The effects of spinal anesthesia as compared with general anesthesia on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied. METHODS We conducted a pragmatic, randomized superiority tria...

Optimising Early Mobilisation & Rehabilitation in Intensive Care More than forty randomised trials have evaluated early mobilisation and rehabilitation in ICUs in the last decade. These trials usually aim to reduce the incidence of ICU acquired weakness (ICUAW) which is known to be associated with poor long-term survival, poor physical function and decreased quality of life. Eight international guidelines recommend early mobilisation and rehabilitation in inten...

ORIGINAL ARTICLE Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab Anil Gupta, Yaneicy Gonzalez-Rojas, Erick Juarez, et al N Engl J Med 2021; 385:1941-1950DOI: 10.1056/NEJMoa2107934 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) disproportionately results in hospitalization or death in older patients and those with underlying conditions. Sotrovimab is a pan-sarbecovirus monoclonal antibody that was designed to prevent...