EDITORIAL Monoclonal Antibodies with Extended Half-Life to Prevent Covid-19 Jonathan Abraham N Engl J Med 2022; 386:2236-2238DOI: 10.1056/NEJMe2205563 Early treatment (i.e., soon after the onset of Covid-19 symptoms) with monoclonal antibodies that target the SARS-CoV-2 spike protein reduces the risks of Covid-19–related hospitalization and death.1-3 Yet, despite the success of these interventions, in response to continued pressure from human immune respo...

ORIGINAL ARTICLE Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis Joseph N. Jarvis, David S. Lawrence, David B. Meya, et al N Engl J Med 2022; 386:1109-1120DOI: 10.1056/NEJMoa2111904 Abstract BACKGROUND Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B would be efficacious i...

EDITORIALFREE PREVIEW Intravenous Fluids in Septic Shock — More or Less? Lauralyn A. McIntyre, John C. Marshall N Engl J Med June 17, 2022DOI: 10.1056/NEJMe2206160 …soon the sharpened features, and sunken eye, and fallen jaw, pale and cold, bearing the manifest impress of death’s signet, began to glow with returning animation…. “. . . 很快，瘦削的五官、凹陷的眼睛和下垂的下巴，苍白而冰冷的皮肤，这些明显的死亡迹象开始重新焕发活力。” — Dr. Thomas Latta D...

ORIGINAL ARTICLE Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults Lianpan Dai, Lidong Gao, Lifeng Tao, et al N Engl J Med May 4, 2022DOI: 10.1056/NEJMoa2202261 Abstract BACKGROUND The ZF2001 vaccine, which contains a dimeric form of the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 and aluminum hydroxide as an adjuvant, was shown to be safe, with an acceptable side-effect profile, and immunogenic i...

Editorial May 5, 2022 Strategic Opportunities to Improve Stroke Systems of Care Kori S. Zachrison, Lee H. Schwamm JAMA. 2022;327(18):1765-1767. doi:10.1001/jama.2022.3820 Restoring reperfusion to the brain as quickly as possible during acute ischemic stroke is important to reduce long-term disability and optimize clinical outcomes for patients, although hospital and resource availability are frequently not well matched with patient location. Accordingly, ...

Original Investigation May 2, 2022 Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes Elisabeth McClymont, Arianne Y. Albert, Gillian D. Alton, et al JAMA. Published online May 2, 2022. doi:10.1001/jama.2022.5906 Key Points Question  Is SARS-CoV-2 infection during pregnancy associated with increased risk of adverse maternal and perinatal outcomes? Findings  This Canadian surveillan...

Editorial March 22, 2022 Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status Jean M. Connors, Paul M Ridker JAMA. Published online March 22, 2022. doi:10.1001/jama.2022.2361 Thrombotic complications of SARS-CoV-2 infection were recognized early in the pandemic, when infected patients often presented with abnormal coagulation findings and acute macrovascular obstruction, and evidence of pulmonary microvas...

ORIGINAL ARTICLE Restriction of Intravenous Fluid in ICU Patients with Septic Shock T.S. Meyhoff, P.B. Hjortrup, J. Wetterslev, et al N Engl J Med June 17, 2022DOI: 10.1056/NEJMoa2202707 BACKGROUND Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU). METHODS In this international, randomized trial, we ...

Original Investigation May 5, 2022 Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany Gordian J. Hubert, Nikolai D. Hubert, Christian Maegerlein, et al JAMA. 2022;327(18):1795-1805. doi:10.1001/jama.2022.5948 Key Points Question  In a nonurban region in Germany, is the deployment of a flying intervention tea...

Original Investigation Caring for the Critically Ill PatientMarch 22, 2022 Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial REMAP-CAP Writing Committee for the REMAP-CAP Investigators JAMA. Published online March 22, 2022. doi:10.1001/jama.2022.2910 Key Points Question  Does antiplatelet therapy administered to critically ill patients with CO...