Research Public health impact of covid-19 vaccines in the US: observational study Amitabh Bipin Suthar, Jing Wang, Victoria Seffren, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069317 (Published 27 April 2022)Cite this as: BMJ 2022;377:e069317 Abstract Objective To evaluate the impact of vaccine scale-up on population level covid-19 mortality and incidence in the United States. Design Observational study. Setting US county...

Editorial March 8, 2022 Predictive Models for Acute Kidney Injury Following Cardiac Surgery: The Importance of Accurate and Actionable Prediction Marlies Ostermann, Nuttha Lumlertgul, Francis Perry Wilson JAMA. 2022;327(10):927-929. doi:10.1001/jama.2022.1823 Acute kidney injury (AKI) complicates recovery from cardiac surgery in up to 40% of patients; impairs the function of the heart, lungs, brain, and gut; and is associated with an increased r...

Research Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study Ioannis Katsoularis, Osvaldo Fonseca-Rodríguez, Paddy Farrington, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069590 (Published 06 April 2022)Cite this as: BMJ 2022;377:e069590 Abstract Objective To quantify the risk of deep vein thrombosis, pulmonary embolism, and bleeding after covid-1...

Original Investigation Caring for the Critically Ill PatientMay 15, 2022 Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure: A Randomized Clinical Trial Waleed Alhazzani, Ken Kuljit S. Parhar, Jason Weatherald, et al JAMA. Published online May 15, 2022. doi:10.1001/jama.2022.7993 Key Points Question  Does prone positioning reduce endotracheal intubation in adults who ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalsLong-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemiaGranholm A. et al. Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admissionOhbe H. et al. Diarrhea during critical illness: a multicenter cohort studyDionne J.C. et al. Long-term mortality and health-related quality of life of lower ver...

Original Investigation March 8, 2022 Predictive Accuracy of a Perioperative Laboratory Test–Based Prediction Model for Moderate to Severe Acute Kidney Injury After Cardiac Surgery Sevag Demirjian, C. Allen Bashour, Andrew Shaw, et al JAMA. 2022;327(10):956-964. doi:10.1001/jama.2022.1751 Key Points Question  Can a model be developed based on perioperative metabolic panel laboratory values to predict the risk of acute kidney injury (...

Original Investigation May 4, 2022 Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial Julian Bösel, Wolf-Dirk Niesen, Farid Salih, et al JAMA. Published online May 4, 2022. doi:10.1001/jama.2022.4798 Key Points Question  Among patients with severe ischemic or hemorrhagic stroke receiving mec...

Editorial April 7, 2022 Selecting Intermediate Respiratory Support Following Extubation in the Pediatric Intensive Care Unit Christopher M. Horvat, Martha A. Q. Curley, Timothy D. Girard JAMA. Published online April 7, 2022. doi:10.1001/jama.2022.4637 Prolonged invasive mechanical ventilation is associated with considerable morbidity among critically ill children, including secondary infections, exposure to potentially neurotoxic sedatives, and ...

ORIGINAL ARTICLEFREE PREVIEW Nasal High-Flow Therapy during Neonatal Endotracheal Intubation Kate A. Hodgson, Louise S. Owen, C. Omar F. Kamlin, et al N Engl J Med 2022; 386:1627-1637DOI: 10.1056/NEJMoa2116735 Abstract BACKGROUND Neonatal endotracheal intubation often involves more than one attempt, and oxygen desaturation is common. It is unclear whether nasal high-flow therapy, which extends the time to desaturation during elective intubation in childr...

Original Investigation Caring for the Critically Ill PatientApril 7, 2022 Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill ChildrenA Randomized Clinical Trial Padmanabhan Ramnarayan, Alvin Richards-Belle, Laura Drikite, et al JAMA. Published online April 7, 2022. doi:10.1001/jama.2022.3367 Key Points Question  In critically ...