ORIGINAL ARTICLE Albuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma Alberto Papi, Bradley E. Chipps, Richard Beasley, et al N Engl J Med 2022; 386:2071-2083DOI: 10.1056/NEJMoa2203163 Abstract BACKGROUND As asthma symptoms worsen, patients typically rely on short-acting β2-agonist (SABA) rescue therapy, but SABAs do not address worsening inflammation, which leaves patients at risk for severe asthma exacerbations. The use of a fixed-dose...

ARTICLES|ONLINE FIRST Safety and immunogenicity of a live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine in adults: randomised, double-blind, placebo-controlled, phase 1 and 2 trials Fengcai Zhu, Chunlan Zhuang, Kai Chu, et al Lancet Respir Med Published:May 26, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00131-X Summary Background All currently available SARS-CoV-2 vaccines are administered by intramuscular injection. We aim...

Research Special Paper Visualising harms in publications of randomised controlled trials: consensus and recommendations Rachel Phillips, Suzie Cro, Graham Wheeler, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-068983 (Published 16 May 2022)Cite this as: BMJ 2022;377:e068983 Abstract  Objective To improve communication of harm in publications of randomised controlled trials via the development of recommendations for visually presen...

ARTICLES| VOLUME 10, ISSUE 6, P566-572, JUNE 01, 2022 Vaccine efficacy against severe COVID-19 in relation to delta variant (B.1.617.2) and time since second dose in patients in Scotland (REACT-SCOT): a case-control study Paul M McKeigue, David A McAllister, Sharon J Hutchinson, et al Lancet Respir Med 2022; 10: 566-572 Summary Background Reports have suggested that the efficacy of vaccines against COVID-19 might have fallen since the delt...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 4, P979-988, APRIL 01, 2022 Lung Response to a Higher Positive End-Expiratory Pressure in Mechanically Ventilated Patients With COVID-19 Alessandro Protti, Alessandro Santini, Francesca Pennati, et al Chest 2022; 161: 979-988 Background International guidelines suggest using a higher (> 10 cm H2O) positive end-expiratory pressure (PEEP) in patients with moderate-to-severe ARDS due to...

Editorials Are vaccines a potential treatment for long covid? Manoj Sivan, Trisha Greenhalgh, Ruairidh Milne, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o988 (Published 18 May 2022)Cite this as: BMJ 2022;377:o988 Benefits are possible, but we need more evidence and a mechanism of action Vaccines in the covid-19 pandemic have been a game changer in reducing rates of SARS-CoV-2 infection and hospital admission for, and death with, covid-19. They als...

ARTICLES| VOLUME 10, ISSUE 6, P545-556, JUNE 01, 2022 Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis Jonathan R Baker, Mahdi Mahdi, Dan V Nicolau Jr, et al Lancet Respir Med 2022; 10: 545-556 Summary Background Community-based clinical trials of the inhaled corticosteroid budesonide in early COVID-19 have shown i...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 5, P1275-1284, MAY 01, 2022 Aspirin as a Treatment for ARDS: A Randomized, Placebo-Controlled Clinical Trial Philip Toner, Andrew J. Boyle, James J. McNamee, et al Chest 2022; 161: 1275-1284 Background There is no pharmacologic treatment for ARDS. Platelets play an important role in the pathophysiology of ARDS. Preclinical, observational, and clinically relevant models of ARDS indicate aspir...

Editorial  July 19, 2022 Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery: New Evidence and Arguments in the Timeless Debate Mihai V. Podgoreanu, Negmeldeen Mamoun JAMA. 2022;328(3):246-248. doi:10.1001/jama.2022.10113 Adequate intravenous (IV) fluid administration is essential during and after cardiac surgery to restore circulating blood volume and improve end-organ tissue perfusion. Clinical decisions about which fluid type...

ARTICLES|ONLINE FIRST Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study The PHOSP-COVID Collaborative Group Lancet Respir Med Published:April 23, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00127-8 Summary Background No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed...