This is an officialCDC HEALTH ADVISORY Distributed via the CDC Health Alert Network May 24, 2022, 9:00 AM ETCDCHAN-0467 COVID-19 Rebound After Paxlovid Treatment Summary The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to update healthcare providers, public health departments, and the public on the potential for recurrence of COVID-19 or “COVID-19 rebound.” Paxlovid continues to be recomm...

Indirect Calorimetry in Critically Ill Patients In a new review, the authors identify the pros and cons of indirect calorimetry to estimate resting energy expenditure and define individual nutritional energy targets among critically ill patients.  Indirect calorimetry (IC) is a monitoring tool that provides factual information on metabolism. There is significant evidence to show an important association between mortality and calorie intake in early critical...

Original Investigation  June 4, 2022 Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial Melanie Meersch, Raphael Weiss, Mira Küllmar, et al JAMA. Published online June 4, 2022. doi:10.1001/jama.2022.9451 Key Points Question  Among adults undergoing extended surgical procedures, what is the effect of an intraoperative ...

Medical News & Perspectives  June 8, 2022 From Positive to Negative to Positive Again—The Mystery of Why COVID-19 Rebounds in Some Patients Who Take Paxlovid Rita Rubin JAMA. Published online June 8, 2022. doi:10.1001/jama.2022.9925 David Ho, MD, managed to avoid contracting COVID-19 for more than 2 years. But SARS-CoV-2 finally got the best of the pioneering HIV researcher on an April trip to Paris for, of all things, a 2-day COVID-19...

Original Investigation  January 27, 2022 Clinical Characteristics and Outcomes of Patients With COVID-19–Associated Acute Respiratory Distress Syndrome Who Underwent Lung Transplant Chitaru Kurihara, Adwaiy Manerikar, Melissa Querrey, et al JAMA. 2022;327(7):652-661. doi:10.1001/jama.2022.0204 Key Points Question  What were the clinical outcomes of patients who underwent a lung transplant after developing COVID-19–associated acute respirat...

Long COVID and Recovery Following Hospitalisation More than 500 million cases of COVID-19 have been reported worldwide. Patients infected with COVID-19 are at a higher risk of persisting health impairments six months after hospital discharge associated with reduced physical function and health and quality of life. It is thus important to understand the long-term trajectory of recovery from COVID-19. There is very limited information about the long-term sequelae ...

Original Investigation  June 5, 2022 Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial Ethan Basch, Deborah Schrag, Sydney Henson, et al JAMA. Published online June 5, 2022. doi:10.1001/jama.2022.9265 Key Points Question  In patients undergoing cancer treatment, does electronic symptom monitoring improve quality-of-life (QOL) outcomes? Findin...

Medical News & Perspectives  June 8, 2022 American Thoracic Society 2022 Conference Highlights Kristin Walter JAMA. Published online June 8, 2022. doi:10.1001/jama.2022.8598 Studies that examined whether prone positioning or undergoing a lung transplant are effective approaches in treating COVID-19 were among the diverse presentations at the American Thoracic Society’s (ATS) recent annual conference. In this May 26 conversation, Andrew J....

Research Letter  June 13, 2022 Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021 Jefferson M. Jones, Jean D. Opsomer, Mars Stone, et al JAMA. Published online June 13, 2022. doi:10.1001/jama.2022.9745 By testing for both SARS-CoV-2 spike and nucleocapsid antibodies, seroprevalence studies can estimate the proportion of a population with antibodies from previous infe...

Less is More in Delirium Critical care physicians often use ineffective treatments that lack evidence-based data. This is especially true for delirium. To date, no medications have demonstrated therapeutic benefit for this condition. Medical treatment is either targeted toward preventing delirium or treating agitation associated with it. Behavioural interventions are rarely incorporated.  Delirium has a high incidence among critically ill patients. Approxim...