Editorials Molnupiravir’s authorisation was premature James M Brophy BMJ 2022; 376 doi: https://doi.org/10.1136/bmj.o443 (Published 03 March 2022)Cite this as: BMJ 2022;376:o443 Regulatory decisions fall short of the wise stewardship required during a pandemic On 1 October 2021 Merck issued a press release1 reporting an interim analysis of Move-Out, a phase 3 randomised placebo controlled trial in unvaccinated adults with confirmed SARS-Co-V infection ...

Research Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study BMJ 2022;376:e068208 doi: https://doi.org/10.1136/bmj-2021-068208 (Published 10 March 2022) Abstract Objectives To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) to estimate mortality and disability trends for the population aged ≥70 and eval...

Viewpoint March 31, 2022 Reducing “COVID-19 Misinformation” While Preserving Free Speech William M. Sage, Y. Tony Yang JAMA. 2022;327(15):1443-1444. doi:10.1001/jama.2022.4231 Misinformation about risks, prevention, and treatment of COVID-19 has cost lives. Misinformation comes from many sources, with many motives for spreading and believing it. In caring capably and compassionately for patients, a substantial majority of health professionals and health c...

Delirium Motor Subtypes in ICU Patients Delirium is the most common cerebral dysfunction in the ICU, affecting nearly one-third of patients. Based on its clinical manifestation, it can be divided into a hypoactive, hyperactive, or mixed motor subtype. Patients with hyperactive delirium are usually in an agitated state of mind and can display symptoms of aggression and restlessness. Patients with hypoactive delirium are in an apathetic state of mind and can display ...

Editorials The benefits of large scale covid-19 vaccination Christopher Dye BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o867 (Published 27 April 2022)Cite this as: BMJ 2022;377:o867 New evidence confirms that fewer people die in better vaccinated communities The first covid-19 vaccines were administered under emergency use authorisation in December 2020, just one year into the pandemic, a “miracle” of pharmaceutical innovation that has saved an estimated...

Research Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials BMJ 2022;376:e066785  doi: https://doi.org/10.1136/bmj-2021-066785 (Published 09 March 2022) Abstract Objective To systematically compare the effect of direct oral anticoagulants and low molecular weight heparin for thromboprophylax...

ICU Management & Practice, Volume 22 - Issue 1, 2022 Monitoring Postoperative Hypotension – A Futuristic Look at Patient Safety Post-operative hypotension is a frequent occurrence that is unrecognised with intermittent spot checks based monitoring in most hospital ward patients. Myocardial injury is strongly associated with hypotension in this period of recovery from surgery. Upgrading ward monitoring to portable, smart, and continuous systems with effectiv...

Original Investigation April 5, 2022 Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial Michela Guglieri, Kate Bushby, Michael P. McDermott, et al JAMA. 2022;327(15):1456-1468. doi:10.1001/jama.2022.4315 Key Points Question  What is the difference in clinical outcomes among 3 corticosteroid regimens (0.75 mg/kg of daily prednisone, 0.90 mg/kg of daily d...

Research Public health impact of covid-19 vaccines in the US: observational study Amitabh Bipin Suthar, Jing Wang, Victoria Seffren, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-069317 (Published 27 April 2022)Cite this as: BMJ 2022;377:e069317 Abstract Objective To evaluate the impact of vaccine scale-up on population level covid-19 mortality and incidence in the United States. Design Observational study. Setting US county...

Editorial March 8, 2022 Predictive Models for Acute Kidney Injury Following Cardiac Surgery: The Importance of Accurate and Actionable Prediction Marlies Ostermann, Nuttha Lumlertgul, Francis Perry Wilson JAMA. 2022;327(10):927-929. doi:10.1001/jama.2022.1823 Acute kidney injury (AKI) complicates recovery from cardiac surgery in up to 40% of patients; impairs the function of the heart, lungs, brain, and gut; and is associated with an increased r...