Editorial  September 6, 2022 Clinical Decision Support to Prevent Acute Kidney Injury After Cardiac Catheterization: Moving Beyond Process to Improving Clinical Outcomes Eric R. Gottlieb, Mallika Mendu JAMA. 2022;328(9):831-832. doi:10.1001/jama.2022.14070 Over the past decade, with the advent of meaningful use as part of the 2009 Health Information Technology for Economic and Clinical Health (HITECH) Act, the US health care system has experi...

Original Investigation  August 9, 2022 Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial RESCUE BT Trial Investigators JAMA. 2022;328(6):543-553. doi:10.1001/jama.2022.12584 Key Points Question  Among patients with large vessel occlusion acute ischemic stroke, does administration of intravenous tirofiban befo...

Research Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study Isobel L Ward, Charlotte Bermingham, Daniel Ayoubkhani, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070695 (Published 02 August 2022)Cite this as: BMJ 2022;378:e070695 Abstract Objective To assess the risk of covid-19 death after infection with omicron BA.1 compared with delta (B.1.617.2). Design ...

#EA22: Impact of Fatigue on Doctors and Nurses Consultant Anaesthetist Dr Nancy Redfern of Newcastle Hospitals NHS Foundation Trust, Newcastle, U.K., presented a review at Euroanaesthesia 2022 highlighting the potentially lethal effects of fatigue on doctors and nurses, its impact on the quality of their clinical work and judgement and its subsequent impact on patient safety. According to Dr Redfern, healthcare systems need to have formal risk management systems...

Research Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records Elsie M F Horne, William J Hulme, Ruth H Keogh, et al BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-071249 (Published 20 July 2022)Cite this as: BMJ 2022;378:e071249 Abstract Objective To estimate waning of covid-19 vaccine effectiveness over six months after second dose. Desi...

Original Investigation  September 6, 2022 Effect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial Matthew T. James, Bryan J. Har, Benjamin D. Tyrrell, et al JAMA. 2022;328(9):839-849. doi:10.1001/jama.2022.13382 Key Points Question  What is the effectiveness of clinical decision support, accompanied by audit and feedb...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P346-355, AUGUST 01, 2022 Defibrotide Therapy for SARS-CoV-2 ARDS David Frame, Gianni B. Scappaticci, Thomas M. Braun, et al Chest 2022; 162: 346-355 Published:April 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.03.046 Background SARS-CoV-2-related ARDS is associated with endothelial dysfunction and profound dysregulation of the thrombotic-fibrinolytic pathway. Defibrotide is a pol...

#EA22: Preventing Maternal Deaths In a very relevant session at Eurananesthesia 2022, Dr Nuala Lucas, an Obstetric Anaesthesia Expert from Northwick Park Hospital, London, U.K., presented key messages for anaesthesia practice from U.K.'s Maternal Mortality Reports. These reports are produced annually to provide information about the causes of maternal deaths and promote learning and reduce preventable mortality. The U.K. Maternal Mortality Enquiry programme is led ...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P356-366, AUGUST 01, 2022 Targeted Temperature Management After In-Hospital Cardiac Arrest: An Ancillary Analysis of Targeted Temperature Management for Cardiac Arrest With Nonshockable Rhythm Trial Data Alexiane Blanc, Gwenhael Colin, Alain Cariou, et al Chest 2022; 162: 356-366 Published:March 19, 2022 DOI:https://doi.org/10.1016/j.chest.2022.02.056 Background Targeted temperature ma...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P331-345, AUGUST 01, 2022 The Influence of the COVID-19 Pandemic on Intensivists’ Well-Being: A Qualitative Study Kelly C. Vranas, Sara E. Golden, Shannon Nugent, et al Chest 2022; 162: 331-345 Published:May 11, 2022 DOI:https://doi.org/10.1016/j.chest.2022.05.003 Background The COVID-19 pandemic has strained health care systems and has resulted in widespread critical care staffing sho...