Editorial Published: 13 May 2022 Corticosteroids for severe community-acquired pneumonia: a story without an ending Bram Rochwerg  Intensive Care Medicine (2022) https://doi.org/10.1007/s00134-022-06699-w Regardless of pathogen, lower respiratory tract infection is associated with profound host response leading to altered permeability of the alveolar capillary membrane due to complex systemic and pulmonary inflammatory/immune responses [1,2,3]. As such, var...

ARTICLES| VOLUME 10, ISSUE 6, P557-565, JUNE 01, 2022 Comparative vaccine effectiveness against severe COVID-19 over time in US hospital administrative data: a case-control study Bill J Wright, Samuel Tideman, George A Diaz, et al Lancet Respir Med 2022; 10: 557-565 Summary Background Research suggests the protection offered by COVID-19 vaccines might wane over time, prompting consideration of booster vaccinations. Data on which vaccines o...

ORIGINAL ARTICLE A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection L. Helena Gutierrez Sanchez, Henry Shiau, Julia M. Baker, et al N Engl J Med July 13, 2022DOI: 10.1056/NEJMoa2206294 Abstract BACKGROUND Human adenoviruses typically cause self-limited respiratory, gastrointestinal, and conjunctival infections in healthy children. In late 2021 and early 2022, several previously healthy children were identified with acute hepati...

Should We Wean Patients off Vasopressors before Weaning Them off Ventilation? Xavier Monnet Am J Respir Crit Care Med 2022; 205: 980-981 Failed extubation and subsequent reintubation are independently associated with mortality and morbidity of patients under mechanical ventilation (1). This is the reason why, before starting the weaning process, one carefully waits until the patient has reached a sufficient degree of autonomy (2). Among the criteria used to ensur...

Original Published: 13 May 2022 Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial Adrien Bouglé, Sophie Tuffet, Laura Federici, et al Intensive Care Med 13 May 2022 https://doi.org/10.1007/s00134-022-06690-5 Abstract Purpose Compared to long duration of antibiotic therapy, a short duration has a comparable clinical efficac...

ARTICLES|ONLINE FIRST Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial Cameron R Wolfe, Kay M Tomashek, Thomas F Patterson, et al Lancet Respir Med Published:May 23, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00088-1 Summary Background Baricitinib and dexamethasone have randomised trials supporting their use for the treatment of patients with COVID-19. We a...

The Job Crisis for Emergency Physicians Emergency physicians have always been guaranteed a good job after residency and have been able to find work wherever they wanted and whenever they wanted.  However, in recent years there has been a shift in the demand. According to data from the American College of Emergency Physicians (ACEP), in 2019, approximately 20% of emergency medicine residents reported that they had difficulty finding a job in their preferred ...

Randomized Clinical Study of Temporary Transvenous Phrenic Nerve Stimulation in Difficult-to-Wean Patients Martin Dres,  Marcelo Gama de Abreu,  Hamid Merdji, et al Am J Respir Crit Care Med Vol 205, Iss 10, pp 1169–1178, May 15, 2022 Abstract Rationale: Diaphragm dysfunction is frequently observed in critically ill patients with difficult weaning from mechanical ventilation. Objectives: To evaluate the effects of temporary transvenous diaphragm n...

Research Letter May 13, 2022 Risk of Infection and Hospitalization Among Vaccinated and Unvaccinated Children and Adolescents in New York After the Emergence of the Omicron Variant Vajeera Dorabawila, Dina Hoefer, Ursula E. Bauer, et al JAMA. Published online May 13, 2022. doi:10.1001/jama.2022.7319 In the US, 12.3 million youth aged 18 years and younger were diagnosed with COVID-19 by April 7, 2022.1 Studies conducted before the Omicron variant...

COMMENT|ONLINE FIRST What a second booster dose of mRNA COVID-19 vaccines tells us Paul Loubet, Odile Launay Lancet Infect Dis May 09, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00282-1 Real-world studies have shown waning vaccine effectiveness against both SARS-CoV-2 infection and COVID-19-related hospitalisation within 2·5 months after a first booster dose of COVID-19 mRNA vaccine, especially for the SARS-CoV-2 omicron (B.1.1.529) variant. 1Several...