Editorials Are vaccines a potential treatment for long covid? Manoj Sivan, Trisha Greenhalgh, Ruairidh Milne, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj.o988 (Published 18 May 2022)Cite this as: BMJ 2022;377:o988 Benefits are possible, but we need more evidence and a mechanism of action Vaccines in the covid-19 pandemic have been a game changer in reducing rates of SARS-CoV-2 infection and hospital admission for, and death with, covid-19. They als...

ARTICLES| VOLUME 10, ISSUE 6, P545-556, JUNE 01, 2022 Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis Jonathan R Baker, Mahdi Mahdi, Dan V Nicolau Jr, et al Lancet Respir Med 2022; 10: 545-556 Summary Background Community-based clinical trials of the inhaled corticosteroid budesonide in early COVID-19 have shown i...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 5, P1275-1284, MAY 01, 2022 Aspirin as a Treatment for ARDS: A Randomized, Placebo-Controlled Clinical Trial Philip Toner, Andrew J. Boyle, James J. McNamee, et al Chest 2022; 161: 1275-1284 Background There is no pharmacologic treatment for ARDS. Platelets play an important role in the pathophysiology of ARDS. Preclinical, observational, and clinically relevant models of ARDS indicate aspir...

Editorial  July 19, 2022 Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery: New Evidence and Arguments in the Timeless Debate Mihai V. Podgoreanu, Negmeldeen Mamoun JAMA. 2022;328(3):246-248. doi:10.1001/jama.2022.10113 Adequate intravenous (IV) fluid administration is essential during and after cardiac surgery to restore circulating blood volume and improve end-organ tissue perfusion. Clinical decisions about which fluid type...

ARTICLES|ONLINE FIRST Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study The PHOSP-COVID Collaborative Group Lancet Respir Med Published:April 23, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00127-8 Summary Background No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed...

EDITORIAL Acute Hepatitis in Children in 2022 — Human Adenovirus 41? Saul J. Karpen N Engl J Med July 13, 2022DOI: 10.1056/NEJMe2208409 Acute hepatitis in children is certainly not new, and it can be worrisome. Successful worldwide vaccination campaigns over the past few decades have led to demonstrable improvements in public health and well-being by reducing the incidence and consequences of two viral causes — hepatitis A and B viruses. Many other viruses, so...

Original Investigation  July 19, 2022 Effect of 4% Albumin Solution vs Ringer Acetate on Major Adverse Events in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Randomized Clinical Trial Eero Pesonen, Hanna Vlasov, Raili Suojaranta, et al JAMA. 2022;328(3):251-258. doi:10.1001/jama.2022.10461 Key Points Question  Does use of 4% albumin solution compared with Ringer acetate as cardiopulmonary bypass prime and pe...

ARTICLES|ONLINE FIRST Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-centre trial Jing-Xin Li, Shi-Po Wu, Xi-Ling Guo, et al Lancet Respir Med Published:May 20, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00087-X Summary Background Due to waning immunity and protection again...

ORIGINAL ARTICLE Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause Chayarani Kelgeri, Michael Couper, Girish L. Gupte, et al N Engl J Med July 13, 2022DOI: 10.1056/NEJMoa2206704 Abstract BACKGROUND Since January 2022, there has been an increase in reports of cases of acute hepatitis of unknown cause in children. Although cases have been reported across multiple continents, most have been reported in the United Kingdom. Investigations ar...

ARTICLES|ONLINE FIRST Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial Andrei M Darie, Nina Khanna, Kathleen Jahn, et al Lancet Respir Med Published:May 23, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00086-8 Summary Background PCR-based testing has transformed the management...