Medical News & Perspectives May 18, 2022 SARS-CoV-2 RNA Can Persist in Stool Months After Respiratory Tract Clears Virus Rita Rubin, MA JAMA. Published online May 18, 2022. doi:10.1001/jama.2022.7892 SARS-CoV-2, or at least pieces of it, sticks around longer in some infected individuals than respiratory sample testing would suggest, a recent study found. After respiratory samples tested negative, a small proportion of the 113 study pa...

Original Investigation  June 6, 2022 Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure and Mortality by Black vs Non-Black Race Orlando M. Gutiérrez, Yingying Sang, Morgan E. Grams, et al JAMA. Published online June 6, 2022. doi:10.1001/jama.2022.8801 Key Points Question  Compared with estimated glomerular filtration rate (eGFR) equations that include Black vs non-Black race or cystatin C, do e...

Original Investigation  July 26, 2022 Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial Jia Shi, Chenghui Zhou, Wei Pan, et al JAMA. 2022;328(4):336-347. doi:10.1001/jama.2022.10725 Key Points Question  Among patients undergoing cardiac surgery with cardiopulmonary bypass, is there a differenc...

Research Effectiveness of heterologous and homologous covid-19 vaccine regimens: living systematic review with network meta-analysis Wing Ying Au, Peter Pak-Hang Cheung BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2022-069989 (Published 31 May 2022)Cite this as: BMJ 2022;377:e069989 Abstract Objective To evaluate the effectiveness of heterologous and homologous covid-19 vaccine regimens with and without boosting in preventing covid-19 related infecti...

Research Letter May 20, 2022 Excess Mortality in Massachusetts During the Delta and Omicron Waves of COVID-19 Jeremy Samuel Faust, Chengan Du, Chenxue Liang, et al JAMA. Published online May 20, 2022. doi:10.1001/jama.2022.8045 The COVID-19 pandemic has produced excess deaths, the number of all-cause fatalities exceeding the expected number in any period.1,2 Given reports that the Omicron variant may confer less risk than prior variants, we comp...

ORIGINAL ARTICLE Albuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma Alberto Papi, Bradley E. Chipps, Richard Beasley, et al N Engl J Med 2022; 386:2071-2083DOI: 10.1056/NEJMoa2203163 Abstract BACKGROUND As asthma symptoms worsen, patients typically rely on short-acting β2-agonist (SABA) rescue therapy, but SABAs do not address worsening inflammation, which leaves patients at risk for severe asthma exacerbations. The use of a fixed-dose...

ARTICLES|ONLINE FIRST Safety and immunogenicity of a live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine in adults: randomised, double-blind, placebo-controlled, phase 1 and 2 trials Fengcai Zhu, Chunlan Zhuang, Kai Chu, et al Lancet Respir Med Published:May 26, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00131-X Summary Background All currently available SARS-CoV-2 vaccines are administered by intramuscular injection. We aim...

Research Special Paper Visualising harms in publications of randomised controlled trials: consensus and recommendations Rachel Phillips, Suzie Cro, Graham Wheeler, et al BMJ 2022; 377 doi: https://doi.org/10.1136/bmj-2021-068983 (Published 16 May 2022)Cite this as: BMJ 2022;377:e068983 Abstract  Objective To improve communication of harm in publications of randomised controlled trials via the development of recommendations for visually presen...

ARTICLES| VOLUME 10, ISSUE 6, P566-572, JUNE 01, 2022 Vaccine efficacy against severe COVID-19 in relation to delta variant (B.1.617.2) and time since second dose in patients in Scotland (REACT-SCOT): a case-control study Paul M McKeigue, David A McAllister, Sharon J Hutchinson, et al Lancet Respir Med 2022; 10: 566-572 Summary Background Reports have suggested that the efficacy of vaccines against COVID-19 might have fallen since the delt...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 4, P979-988, APRIL 01, 2022 Lung Response to a Higher Positive End-Expiratory Pressure in Mechanically Ventilated Patients With COVID-19 Alessandro Protti, Alessandro Santini, Francesca Pennati, et al Chest 2022; 161: 979-988 Background International guidelines suggest using a higher (> 10 cm H2O) positive end-expiratory pressure (PEEP) in patients with moderate-to-severe ARDS due to...