Research Letter  October 19, 2022 Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial Stuart H. Cohen, Thomas J. Louie, Matthew Sims, et al JAMA. Published online October 19, 2022. doi:10.1001/jama.2022.16476 Antibiotics are necessary but often insufficient to treat recurrent Clostridioides difficile infection (rCDI) due to pe...

Original Investigation  October 22, 2022 Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection Christine Johnston, Amalia Magaret, Hyunju Son, et al JAMA. Published online October 22, 2022. doi:10.1001/jama.2022.19061 Key Points Question  What are the rates of viral shedding after first-episode genital herpes simplex virus type 1 (HSV-1) infection? Findings  In this prospective cohort study, 82 partic...

#LIVES2022: High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy - SOHO-COVID At the Presidents' Ground Breaking Research Release session at ESICM LIVES 2022 in Paris, Jean-Pierre Frat (Poitiers, France) presented the findings from the Standard Oxygen Versus High Flow Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure (SOHO-COVID) trial.  COVID-19 has resulted in over six million deaths worldwide due to acute hypoxaemic respira...

Original Investigation  October 21, 2022 Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial Susanna Naggie, David R. Boulware, Christopher J. Lindsell, et al JAMA. Published online October 21, 2022. doi:10.1001/jama.2022.18590 Key Points Question  Does ivermectin, 400 μg/kg, daily for 3 days, compared with placebo, shorten symptom duration among...

#LIVES2022: Extubation Strategies in Neuro-Intensive Care Unit Patients Findings from the Extubation strategies and in Neuro-Intensive care unit patients and associations with Outcomes (ENIO) study were presented this week at ESICM LIVES 2022.  Invasive mechanical ventilation is a primary intervention in critically ill patients. Timely weaning reduces the risk of hospital-acquired pneumonia, chronic illness and cost of care. In particular, neurocritical car...

Research Post-acute sequelae of covid-19 six to 12 months after infection: population based study Raphael S Peter, Alexandra Nieters, Hans-Georg Kräusslich, et al BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071050 (Published 13 October 2022)Cite this as: BMJ 2022;379:e071050 Abstract Objectives To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, describe risk factors, and examine the associat...

Research Letter  September 23, 2022 Odds of Hospitalization for COVID-19 After 3 vs 2 Doses of mRNA COVID-19 Vaccine by Time Since Booster Dose Jessica P. Ridgway, Samuel Tideman, Thomas French, et al JAMA. 2022;328(15):1559-1561. doi:10.1001/jama.2022.17811 Vaccination with a booster dose of COVID-19 mRNA vaccine has been associated with decreased risk of developing severe COVID-19 compared with no vaccination.1,2 However, among individuals alrea...

Clinical Subtypes in Sepsis Survivors The risk of late mortality in sepsis survivors can persist for years with high readmission rates and poor quality of life. However, due to an incomplete understanding of the relevant causal mechanisms of post-sepsis syndrome, there has been limited success in implementing preventive interventions.  The French and European Outcome Registry in Intensive Care Units (FROG-ICU) prospective, observational, multicentre study w...

ARTICLES| VOLUME 400, ISSUE 10360, P1334-1344, OCTOBER 15, 2022 Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial PREP-IT Investigators Lancet 2022; 400: 1334-1344 Summary Background Chlorhexidine skin antisepsis is frequently recommended for most surgical procedures; however, it is unclear if these recommendations should apply to surgery involving trau...

ARTICLES| VOLUME 400, ISSUE 10360, P1305-1320, OCTOBER 15, 2022 Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales Utkarsh Agrawal, Stuart Bedston, Colin McCowan, et al Lancet 2022; 400: 1305-1320 Summary Background Current UK vaccination policy is to offer future COVID-19...