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Does Size Matter When Calculating the “Correct” Tidal Volume for Pediatric Mechanical Ventilation?: A Hypothesis Based on FVC Gina J. Kim, Christopher J.L. Newth, Robinder G. Khemani, et al Chest 2018; 154: 77-83 Background 背景 Tidal volumes standardized to predicted body weight are recommended for adult mechanical ventilation, but children are frequently ventilated by using measured body weight. The goal of this study was to examine the difference in FVC (in milliliter...
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Intensive Care Medicine ONLINE FIRST (FREE ACCESS) From the Inside ~ Nicola Petrucci et al. Beyond bleeps and alarms: live music by the bedside in the ICU. Systematic Review ~ Sarah Vollam et al. Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis. Understanding the Disease ~ Pierre Tattevin et al. Understanding central nervous system efficacy of antimicrobials. Original ~ Daniel E. F...
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Perspective > Medscape Critical Care > Critical Issues COMMENTARY A Negative APRV Trial in ARDS Aaron B. Holley, MD June 29, 2018 Recently, I reviewed a randomized, controlled trial (RCT)[1] comparing acute respiratory distress syndrome (ARDS) management with protocolized airway pressure release ventilation (APRV) with low-tidal-volume (LTV) ventilation. APRV showed superiority for the primary outcome, ventilator-free days, and a number of secondary outcomes. Mo...
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Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial Zi-Meng Liu, Juan Chen, Qiuye Kou, et al Intensive Care Med 2018 DOI: https://doi.org/10.1007/s00134-018-5267-9 Purpose 目的 Recent clinical data suggest that terlipressin, a vasopressin analogue, may be more beneficial in septic shock patients than catecholamines. However, terlipressin’s effect on mortality is unknown. We set out to ascertain the ...
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Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial Paolo Caraceni, Oliviero Riggio, Paolo Angeli, et al Lancet 2018; 391: 2417-2429 Summary Background 背景 Evidence is scarce on the efficacy of long-term human albumin (HA) administration in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of aScites in patients With hEpatic ciRrhosis (ANSWER) study was designed to clarify this issue. 长期应用人...
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Perspective > Medscape > Trending Clinical Topics Trending Clinical Topics for June 2018 Ryan Syrek June 29, 2018 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook! Trending Clinical Topic of the Week (June 23-29): Cannabis News about the largest developed country to end ...
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News > Medscape Medical News > Conference News > ESOC 2018 TICH-2: Tranexamic Acid for ICH Yields Mixed Results Damian McNamara June 19, 2018 GOTHENBURG, Sweden — Tranexamic acid for intracranial hemorrhage failed to significantly improve functional status compared with placebo at 90 days in a randomized controlled study. However, the antifibrinolytic agent was associated with a decrease in deaths in the first week and attenuation of hematoma expansion. The pri...
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Does Point-of-Care Ultrasonography Improve Clinical Outcomes in Emergency Department Patients With Undifferentiated Hypotension? An International Randomized Controlled Trial From the SHoC-ED Investigators Paul R. Atkinson,James Milne, Laura Diegelmann, et al Ann Emerg Med. 2018 Study objective: 研究目的 Point-of-care ultrasonography protocols are commonly used in the initial management of patients with undifferentiated hypotension in the emergency department (ED). There is...
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Review Article Paradigms of acute kidney injury in the intensive care setting John A. Kellum & John R. Prowle Nature Reviews Nephrology volume 14, pages 217–230 (2018) doi:10.1038/nrneph.2017.184 Figure 1: Principal pathogenic mechanisms of acute kidney injury in the context of sepsis or major surgery. Figure 2: Principal pathogenic mechanisms of acute kidney injury in the context of global hypoperfusion. Figure 3: Principal pathogenic mechanisms of acute kidney inj...
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Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial  Samir Jaber, Catherine Paugam, Emmanuel Futier, et al Lancet 2018 Published: 14 June 2018 DOI: https://doi.org/10.1016/S0140-6736(18)31080-8 Summary Background 背景 Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic ac...
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