Evidence-Based Medicine and the Practice of Personalised Medicine In ICU Fri, 22 Mar 2024 Sharon Einav-Bromiker from Tel Aviv, Israel, delivered a thought-provoking session @ISICEM, exploring the conflict between evidence-based medicine and personalised medicine. She acknowledged the complexity of the topic and aimed to challenge conventional perspectives.  While evidence-based medicine provides a sense of certainty, it may not be as reliable a...

Research Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study Masashi Okubo, Sho Komukai, Lars W Andersen, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-076019 (Published 07 February 2024)Cite this as: BMJ 2024;384:e076019 Abstract Objective To quantify time dependent probabilities of outcomes in patients after in-hospital cardiac arrest as a function of duration of ca...

Editorial  January 17, 2023 TRANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? Michelle M. Kittleson JAMA. 2023;329(3):211-213. doi:10.1001/jama.2022.21692 Fluid overload is the cardinal manifestation of heart failure, and prior to the 20th century, treatment options were limited to purgatives, bloodletting, leeching, or lancing. It was not until 1920 that the concept of a diuretic was first appreciated, when physicians observe...

Research Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial Gordon McGregor, Harbinder Sandhu, Julie Bruce, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-076506 (Published 07 February 2024)Cite this as: BMJ 2024;384:e076506 Abstract Objective To evaluate whether a structured online supervised ...

Sex - A Biological Variable in the ICU In ICU Thu, 21 Mar 2024 Dr Marlies Ostermann from Guy’s and St Thomas’ NHS Foundation Trust in London presented a tutorial at ISICEM 2024, highlighting the historical disparities and inequalities faced by different sexes in the ICU. These challenges encompass lower ICU admission rates, variations in medical care provision, inadequate personalisation, limited representation in clinical trials, and biases.  ...

Invited Commentary  February 7, 2024 Health Insurance for Care—Access-Sensitive Surgical Conditions Casey M. Silver, Anne M. Stey JAMA Surg. Published online February 7, 2024. doi:10.1001/jamasurg.2023.7536 Health care access depends on financial resources to pay for health care. Health insurance allows healthy people to pool resources to pay for health care when one becomes ill or injured. The RAND Corporation’s Health Insurance Experimen...

Original Investigation  January 17, 2023 Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial Robert J. Mentz, Kevin J. Anstrom, Eric L. Eisenstein, et al JAMA. 2023;329(3):214-223. doi:10.1001/jama.2022.23924 Key Points Question  Does torsemide reduce all-cause mortality compared with furosemide in patients with heart fail...

Original Investigation  February 8, 2024 Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: The MARVEL Randomized Clinical Trial MARVEL Trial Authors for the MARVEL Investigators JAMA. Published online February 8, 2024. doi:10.1001/jama.2024.0626 Key Points Question  Among patients with large-vessel occlusion acute ischemic stroke, does adjunctive intravenous methylprednisolone added to ...

Original Investigation  February 7, 2024 Health Insurance Status and Unplanned Surgery for Access-Sensitive Surgical Conditions Shukri H. A. Dualeh, Sara L. Schaefer, Nicholas Kunnath, et al JAMA Surg. Published online February 7, 2024. doi:10.1001/jamasurg.2023.7530 Key Points Question  What is the association between health insurance status and rates and outcomes of unplanned surgery for ac...

ARTICLES|ONLINE FIRST Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial Nicholas Heming, Alain Renault, Emmanuelle Kuperminc, et al Lancet Respir Med Published:February 01, 2024 DOI:https://doi.org/10.1016/S2213-2600(23)00430-7 Summary Background Glucocorticoids probably improve outcomes in patients hospitalised for community acquired pneumonia (CAP)...