Ventilator-Associated Events in Mechanically Ventilated Patients Critically ill patients in the ICU often require life-saving mechanical ventilation. For many, this is an unavoidable intervention, despite the multiple complications associated with it. Ventilator-associated event (VAE) surveillance was proposed in 2013 by a working group of the Centers for Disease Control and Prevention (CDC). Three tiers of VAEs were defined by this group: Ventilator-associated cond...

News News Analysis Covid-19: Are cloth masks still effective? And other questions answered Elisabeth Mahase BMJ 2021; 372: n432 doi: https://doi.org/10.1136/bmj.n432 In light of new, more transmissible variants of SARS-CoV-2, Elisabeth Mahase examines what kinds of mask the public should be wearing, and where they should be worn Are cloth masks still recommended? Early in the pandemic, major problems in the global supply of medical grade m...

Explore the most influential publications by Chinese researchers We are proud to present a selection of the latest high-impact publications* in clinical medicine by Chinese researchers across from Springer Nature. We hope you enjoy reading this selection and find it helpful.  * High-impact publications in their academic fields as of 2020, according to SN Insights. Open access articles are freely available online on a permanent basis. A pneumonia...

Original Investigation March 18, 2021 Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial INSPIRATION Investigators JAMA. Published online March 18, 2021. doi:10.1001/jama.2021.4152 Abstract Importance 背景 Thrombotic events are co...

ONLINE FIRST THIS WEEK(FREE ACCESS) Letter ~ Rousset D. et al. - Bedside ultrasound monitoring of prone position induced lung inflationCOVID-19 in Intensive Care ~ Sandroni C. et al. ~The impact of COVID-19 on the epidemiology, outcome and management of cardiac arrestConference Reports and Expert Panel ~ Domínguez-Gil B. et al. - Expanding controlled donation after the circulatory determination of death: statement from an international collaborativeCOVID-19 in Intensiv...

Research Letter March 1, 2021 Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2 Saman Saadat, Zahra Rikhtegaran Tehrani, James Logue, et al JAMA. Published online March 1, 2021. doi:10.1001/jama.2021.3341 Current shortages in COVID-19 vaccine production and distribution have led some experts to suggest untested regimens.1 Persons who have had COVID-19 are thought to ...

Original Investigation February 26, 2021 Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis Perrine Janiaud, Cathrine Axfors, MD, Andreas M. Schmitt, et al JAMA. Published online February 26, 2021. doi:10.1001/jama.2021.2747 Abstract Importance Convalescent plasma is a proposed treatment for COVID-19. Objective To assess clinical outcomes with convalesc...

ECMO, Mortality and ARDS An in-depth analysis was conducted in Germany to evaluate whether mortailty in Germany in Extracorporeal life support (ECLS) therapy differed from previously reported literature.  Extracorporeal life support (ECLS) is a critical component of intensive care therapy. There are various conditions that require the use of ECLS. The term ECLS encompasses different terms depending on the system and the type of cannulation that is used. Th...

Editorial February 17, 2021 Vitamin D3 to Treat COVID-19: Different Disease, Same Answer David E. Leaf, Adit A. Ginde JAMA. Published online February 17, 2021. doi:10.1001/jama.2020.26850 Biological activity of vitamin D and its metabolites include, among other properties, potent antimicrobial and anti-inflammatory effects in vitro.1 In animal models, administration of vitamin D metabolites attenuates a variety of acute organ dysfunction, i...

ICU Management & Practice, Volume 20 - Issue 4, 2020 Prolonged Intubation and Tracheostomy in COVID-19 Survivors Consequences and Recovery of Laryngeal Function Intubation and tracheostomy as a result of COVID-19 critical illness may result in laryngeal dysfunction, which can lead to serious consequences. This article provides assessment and rehabilitation recommendations for those working with critically ill COVID-19 patients in the ICU. Introduction...