{"id":31318,"date":"2026-10-13T04:30:00","date_gmt":"2026-10-12T20:30:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=31318"},"modified":"2026-10-13T05:56:39","modified_gmt":"2026-10-12T21:56:39","slug":"intensive-care-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%99%a2%e5%a4%96%e5%bf%83%e8%b7%b3%e9%aa%a4%e5%81%9c%e6%82%a3%e8%80%85%e7%9a%84%e6%97%a9%e6%9c%9f%e5%a4%a7%e5%89%82%e9%87%8f%e7%bb%b4","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=31318","title":{"rendered":"[Intensive Care Med\u53d1\u8868\u8bba\u6587]\uff1a\u9662\u5916\u5fc3\u8df3\u9aa4\u505c\u60a3\u8005\u7684\u65e9\u671f\u5927\u5242\u91cf\u7ef4\u751f\u7d20C\u6cbb\u7597"},"content":{"rendered":"\n

Article<\/p>\n\n\n\n

Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial<\/h1>\n\n\n\n

Rozemeijer, S., Dubois, E.A., de Grooth, HJ.\u00a0et al<\/em><\/h3>\n\n\n\n

Intensive Care Med<\/em>\u00a052<\/strong>, 1447\u20131457 (2026)<\/h3>\n\n\n\n

https:\/\/doi.org\/10.1007\/s00134-026-08492-5<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Besides temperature management, there is currently no effective therapy to decrease the burden of post-cardiac arrest syndrome. The pleiotropic effects of vitamin C may improve clinical outcome.<\/p>\n\n\n\n

Purpose<\/h3>\n\n\n\n

This trial investigated whether early administration of 3 g or 10 g intravenous vitamin C attenuated organ dysfunction post-cardiac arrest.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

In this double-blind, multi-center, phase 2 trial, comatose adults resuscitated from shockable out-of-hospital cardiac arrest randomly received intravenously placebo, supplementary (3 g) or supraphysiological dose (10 g) vitamin C daily for 96 h. The primary endpoint was the 96 h change in the resuscitation-sequential organ failure assessment (R-SOFA) score. Secondary endpoints included neurological outcome, myocardial injury, vasopressor- and ventilator-free days, renal function, ICU-acquired weakness, delirium, length of ICU and hospital stay, and 28- and 180-day mortality.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

273 patients (93 on\u00a0placebo, 91\u00a0on 3\u00a0g and 89 on\u00a010\u00a0g) were included in the primary analysis. Mean (SD) change in R-SOFA score at 96\u00a0h was \u2212\u20093.2 (5.7) in the placebo group, \u2212\u20092.3 (7.4) in the 3\u00a0g group, and \u2212\u20090.8 (7.6) in the 10\u00a0g group (p\u2009=\u20090.04 for overall difference). 10\u00a0g vitamin C resulted in 2.5 points less improvement in R-SOFA score compared with placebo (95% CI 0.5\u20134.5; p\u2009=\u20090.01), and 1.6 points less improvement compared with 3\u00a0g vitamin C (95% CI \u2212\u20090.4 to 3.6; p\u2009=\u20090.12). Vitamin C 10\u00a0g led to higher troponin T release, worse renal function and worse neurological outcomes.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
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Conclusion<\/h3>\n\n\n\n

In out-of-hospital cardiac arrest patients, intravenous vitamin C did not reduce organ dysfunction at 96 h, but even worsened organ function outcomes in the 10 g group.<\/p>\n\n\n\n

Trial registration<\/h3>\n\n\n\n

NCT03509662.<\/p>\n","protected":false},"excerpt":{"rendered":"

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