{"id":31128,"date":"2026-06-21T04:10:00","date_gmt":"2026-06-20T20:10:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=31128"},"modified":"2026-06-21T06:00:39","modified_gmt":"2026-06-20T22:00:39","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%a4%a7%e5%89%82%e9%87%8f%e9%9d%99%e8%84%89%e7%bb%b4%e7%94%9f%e7%b4%a0c%e4%b8%8e%e4%b8%a5%e9%87%8d%e7%83%a7%e4%bc%a4%e6%82%a3%e8%80%85%e7%9a%84","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=31128","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u5927\u5242\u91cf\u9759\u8109\u7ef4\u751f\u7d20C\u4e0e\u4e25\u91cd\u70e7\u4f24\u60a3\u8005\u7684\u75c5\u6b7b\u7387\u548c\u5668\u5b98\u529f\u80fd\u969c\u788d"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Caring for the Critically Ill Patient<\/p>\n\n\n\n

High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial<\/h1>\n\n\n\n

Christian\u00a0Stoppe,\u00a0Aileen\u00a0Hill,\u00a0Leopoldo C.\u00a0Cancio,\u00a0et al<\/h3>\n\n\n\n

JAMA Published Online:\u00a0June\u00a010,\u00a02026<\/h3>\n\n\n\n

doi: 10.1001\/jama.2026.10616<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  Does high-dose intravenous vitamin C reduce a composite of 28-day mortality and persistent organ dysfunction in patients with severe burn injury?<\/p>\n\n\n\n

Findings<\/strong>  In this randomized clinical trial that included 238 patients with severe burns, the primary composite outcome of 28-day mortality and persistent organ dysfunction occurred in 40.8% of patients in the intravenous vitamin C group compared with 29.7% in the placebo group. At the first prespecified interim analysis, this result crossed the futility\/harm threshold, prompting early termination of the trial.<\/p>\n\n\n\n

Meaning<\/strong>  High-dose intravenous vitamin C did not reduce mortality and organ dysfunction and may be associated with harm in patients with severe burn injury.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>\u00a0\u00a0Severe burn injury triggers systemic inflammation that can lead to multiple organ dysfunctions and death. High-dose intravenous vitamin C has been proposed to mitigate these effects, but strong evidence in patients with burn injury is lacking.<\/p>\n\n\n\n

Objective<\/strong>  To evaluate the efficacy of high-dose intravenous vitamin C in patients with severe burn injury.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  Randomized, double-blind, placebo-controlled phase 3 trial conducted across 24 burn centers in North, Central, and South America; Europe; and Asia. Adults (\u226518 years) with deep second- and\/or third-degree burns covering 20% or more of total body surface area and requiring skin grafting were enrolled between August 18, 2020, and September 12, 2025. Final follow-up was completed in March 2026. The trial was stopped early after the first prespecified interim analysis for futility\/harm.<\/p>\n\n\n\n

Interventions<\/strong>  Patients were randomly assigned (1:1) to receive intravenous vitamin C (50 mg\/kg every 6 hours for 96 hours) or matched placebo.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was a composite of 28-day mortality and persistent organ dysfunction (defined as dependence on mechanical ventilation, kidney replacement therapy, or vasopressor\/inotrope support at day 28). The main secondary outcome was time to discharge alive from hospital within 90 days.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0Among 238 patients enrolled (mean age, 48.9 [SD, 19.1] years; 79% male; mean total body surface area, 37.0% [SD, 14.6%]), 120 were assigned to vitamin C and 118 to placebo. The primary composite outcome occurred in 49 patients (40.8%) in the vitamin C group and 35 patients (29.7%) in the placebo group (adjusted risk ratio [RR], 1.28 [95% CI, 0.99-1.65];\u00a0P<\/em>\u2009=\u2009.06), crossing the prespecified futility\/harm threshold and prompting early trial termination. Time to discharge alive from hospital within 90 days was not improved (adjusted subdistribution hazard ratio, 0.85 [95% CI, 0.62-1.16];\u00a0P<\/em>\u2009=\u2009.31). Twenty-eight\u2013day mortality was higher in the vitamin C group (15.0% vs 7.6%; adjusted RR, 1.96 [95% CI, 1.32-2.90];\u00a0P<\/em>\u2009=\u2009.001), as was hospital mortality (23.3% vs 16.1%; adjusted RR, 1.44 [95% CI, 1.03-2.00];\u00a0P<\/em>\u2009=\u2009.03).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  Among patients with severe burn injury, high-dose intravenous vitamin C did not reduce 28-day mortality and persistent organ dysfunction and is possibly harmful.<\/p>\n\n\n\n

Trial Registration<\/strong>  ClinicalTrials.gov Identifier: NCT04138394<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Caring for the Critically […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/31128"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31128"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/31128\/revisions"}],"predecessor-version":[{"id":31129,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/31128\/revisions\/31129"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}