{"id":31114,"date":"2026-09-09T04:51:00","date_gmt":"2026-09-08T20:51:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=31114"},"modified":"2026-09-09T05:42:21","modified_gmt":"2026-09-08T21:42:21","slug":"clin-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%92%88%e5%af%b9vre%e5%ae%9a%e6%a4%8d%e7%9a%84%e8%82%9d%e7%a7%bb%e6%a4%8d%e6%82%a3%e8%80%85%e8%bf%9b%e8%a1%8c%e5%9b%b4%e6%89%8b%e6%9c%af","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=31114","title":{"rendered":"[Clin Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u9488\u5bf9VRE\u5b9a\u690d\u7684\u809d\u79fb\u690d\u60a3\u8005\u8fdb\u884c\u56f4\u624b\u672f\u671f\u9884\u9632\u7684\u5f71\u54cd"},"content":{"rendered":"\n

JOURNAL ARTICLE<\/p>\n\n\n\n

Impact of Vancomycin-Resistant Enterococci<\/em> (VRE)\u2013Active Perioperative Prophylaxis in Liver Transplant Patients Colonized by VRE<\/h1>\n\n\n\n

Giulia Jole Burastero, Emmanuel Q Wey, Veronica Guidetti, et al<\/h3>\n\n\n\n

Clinical Infectious Diseases<\/em>, Volume 82, Issue 5, 15 May 2026, Pages 878\u2013887, https:\/\/doi.org\/10.1093\/cid\/ciaf121<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

Data regarding the effectiveness of vancomycin-resistant Enterococci<\/em> (VRE)\u2013active prophylaxis for preventing early post\u2013liver transplantation (LT) VRE infections in VRE-colonized patients are scarce.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

131 pre-LT VRE-colonized patients who underwent LT were enrolled in a retrospective, observational, multicenter study. The incidence of early-onset VRE infections was compared between patients who received active prophylaxis for VRE and those who did not.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

Sixty-nine (52.7%) and 62 (47.3%) patients were enrolled in the VRE-active and non\u2013VRE-active prophylaxis group. Tigecycline was the most common drug prescribed as VRE-active for prophylaxis (55\/69; 79.7%). There was no significant difference in the number of patients who developed early-onset VRE infections in the VRE-active versus non\u2013VRE-active groups at 7 (0 [0.0%] vs 2 [3.2%];\u00a0P<\/em>\u00a0= .222), 14 (4 [5.7%] vs 4 [6.4%];\u00a0P<\/em>\u00a0= 1.000), and 30 (6 [8.7%] vs 8 [12.9%];\u00a0P<\/em>\u00a0= .621) days post-LT, respectively. Risk of early-onset VRE infection within 30 days was not lower in the VRE-active group (log-rank\u00a0P<\/em>\u00a0= .16 with Kaplan-Meier analysis; odds ratio [OR]: .643; 95% CI: .210\u20131.969;\u00a0P<\/em>\u00a0= .439 with univariate analysis). Conversely, early infections caused by any pathogen were significantly lower in the VRE-active prophylaxis group compared with the control group (11 [15.9%] vs 20 [32.2%];\u00a0P<\/em>\u00a0= .047). Tigecycline prophylaxis was associated with a lower risk of early-onset infections with multivariate analysis (OR: .106; 95% CI: .015\u2013.745;\u00a0P<\/em>\u00a0= .024) and after adjusting for propensity score (adjusted OR: .146; 95% CI: .031\u2013.708;\u00a0P<\/em>\u00a0= .017).<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Conclusions<\/p>\n\n\n\n

VRE-active prophylaxis at LT did not reduce the incidence of early post-LT VRE infections and should not be recommended.<\/p>\n","protected":false},"excerpt":{"rendered":"

JOURNAL ARTICLE Impact of Vancomycin-Resistant Ent […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/31114"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31114"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/31114\/revisions"}],"predecessor-version":[{"id":31653,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/31114\/revisions\/31653"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}