{"id":30647,"date":"2026-06-25T04:11:00","date_gmt":"2026-06-24T20:11:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=30647"},"modified":"2026-06-25T05:41:33","modified_gmt":"2026-06-24T21:41:33","slug":"intensive-care-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e8%8b%af%e7%a3%ba%e9%85%b8%e7%91%9e%e5%90%97%e5%94%91%e4%bb%91%e4%b8%8e%e4%b8%99%e6%b3%8a%e9%85%9a%e7%9a%84%e7%9f%ad%e7%a8%8bicu","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=30647","title":{"rendered":"[Intensive Care Med\u53d1\u8868\u8bba\u6587]\uff1a\u82ef\u78fa\u9178\u745e\u5417\u5511\u4ed1\u4e0e\u4e19\u6cca\u915a\u7684\u77ed\u7a0bICU\u8f7b\u9547\u9759"},"content":{"rendered":"\n

Article<\/p>\n\n\n\n

Short-term light sedation with remimazolam besylate versus propofol in the ICU (SHOSREB): a multicentre, randomized, single-blind, controlled trial<\/h1>\n\n\n\n

Yang, X., Pan, J., Gong, X.\u00a0et al.<\/em><\/h3>\n\n\n\n

Intensive Care Med<\/em>\u00a0(2026). https:\/\/doi.org\/10.1007\/s00134-026-08381-x<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Purpose<\/h3>\n\n\n\n

To explore the efficacy and safety of remimazolam besylate in short-term sedation in the ICU in comparison with propofol.<\/p>\n\n\n\n

Method<\/h3>\n\n\n\n

A multicenter, randomized, single-blind, non-inferiority trial was conducted in mechanically ventilated patients, who needed light sedation, defined as Richmond Agitation\u2013Sedation Scale (RASS) scores between \u22122 and\u2009+\u20091. The primary outcome was successful sedation, which was defined as no rescue sedative administered during the study drug infusion period while maintaining RASS scores between \u20132 and\u2009+\u20091 for at least 70% of the total infusion time.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

A total of 164 participants were included and randomized equally into the remimazolam group and the propofol group. Remimazolam was continuously infused for 10.5 [8.1\u201314.7] h and propofol for 11.0 [7.0\u201314.3] h (p<\/em>\u2009=\u20090.534). The median average maintaining dose of remimazolam and propofol was 0.20 [0.19\u20130.30] mg\u00b7kg\u207b1<\/sup>\u00b7h\u207b1<\/sup>\u00a0and 0.61 [0.30\u20131.17] mg\u00b7kg\u207b1<\/sup>\u00b7h\u207b1<\/sup>, respectively. The percentage of participants successfully sedated in both groups was 97.5% (p<\/em>\u2009=\u20090.497) with a difference of 0 (95% confidence interval (CI) \u22126.5% to 6.4%), above the predefined non-inferiority margin of \u22128%. There was no significant difference in the mean percentage of time with target RASS scores between the remimazolam group (88.6%; 95% CI: 84.2%\u201392.9%) and the propofol group (89.4%; 95% CI: 85.0%\u201393.8%) (p<\/em>\u2009=\u20090.543).<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Conclusion<\/h3>\n\n\n\n

Remimazolam besylate could be non-inferior to propofol for achieving successful short-term light sedation in the ICU.<\/p>\n\n\n\n

Trial registration<\/h3>\n\n\n\n

ClinicalTrials.gov identifier: NCT05782894 on Feb 18th, 2023.<\/p>\n","protected":false},"excerpt":{"rendered":"

Article Short-term light sedation with remimazolam besy […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30647"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30647"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30647\/revisions"}],"predecessor-version":[{"id":30648,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30647\/revisions\/30648"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}