{"id":30489,"date":"2026-06-04T04:40:00","date_gmt":"2026-06-03T20:40:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=30489"},"modified":"2026-06-04T10:35:30","modified_gmt":"2026-06-04T02:35:30","slug":"jama-netw-open%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%a4%96%e5%91%a8%e9%9d%99%e8%84%89%e8%be%93%e6%b3%a8%e5%8d%87%e5%8e%8b%e8%8d%af%e7%89%a9%e7%9a%84%e4%b8%8d%e8%89%af%e4%ba%8b%e4%bb%b6","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=30489","title":{"rendered":"[JAMA Netw Open\u53d1\u8868\u8bba\u6587]\uff1a\u5916\u5468\u9759\u8109\u8f93\u6ce8\u5347\u538b\u836f\u7269\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Critical Care Medicine<\/p>\n\n\n\n

Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use: A Systematic Review and Meta-Analysis<\/h1>\n\n\n\n

Shang-Jun ZhangJian, Kuang-Yu Niu, Chen-Bin Chen, et al<\/h3>\n\n\n\n

JAMA Netw Open 2026;9;(3):e260710. doi:10.1001\/jamanetworkopen.2026.0710<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  What is the incidence of adverse events (AEs) and avoidance of central venous catheter (CVC) placement after peripheral intravenous (PIV) administration of vasopressors in adults?<\/p>\n\n\n\n

Findings<\/strong>  In this systematic review and meta-analysis of 49 studies including 33\u202f060 catheters, pooled incidence of minor AEs for all PIV vasopressors was 2%, while pooled incidence of major AEs was 1% for midline and 0% for short PIV catheters. Pooled incidence of CVC avoidance was 60%.<\/p>\n\n\n\n

Meaning<\/strong>  In this study, the incidence of AEs after short-term vasopressor administration through PIV catheters was low, and the findings suggest that with appropriate monitoring, PIV administration might reduce the need for CVC placement.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Peripheral intravenous (PIV) vasopressors are increasingly used but remain associated with adverse events (AEs). Quantifying the incidence of these AEs is essential to guide clinical decision-making regarding PIV vasopressor use.<\/p>\n\n\n\n

Objective<\/strong>  To assess the incidence of AEs and avoidance of central venous catheter (CVC) placement after PIV vasopressor administration in adults with hypotension, shock, or critical illness.<\/p>\n\n\n\n

Data Sources<\/strong>  PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception to December 13, 2025, using medical subject headings and keywords related to peripheral vasopressors.<\/p>\n\n\n\n

Study Selection<\/strong>  Eligible studies included critically ill adults receiving vasopressors via PIV catheters and reported AEs and\/or CVC avoidance.<\/p>\n\n\n\n

Data Extraction and Synthesis<\/strong>  Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 2 investigators independently extracted data and assessed risk of bias. A random-effects model was used, and proportions were pooled using a generalized linear mixed model.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary end point was the pooled incidence of AEs as the proportion among total catheters, and the secondary end point was the pooled proportion of CVC avoidance.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0Forty-nine studies including 33\u202f060 catheters were analyzed. The pooled minor AE incidence was 2.6% (95% CI, 1.4%-4.7%) for norepinephrine, 0.0% (95% CI, 0.0%-24.6%) for epinephrine, 2.9% (95% CI, 1.8%-4.8%) for phenylephrine, 1.4% (95% CI, 0.3%-5.9%) for dopamine, 0.5% (95% CI, 0.1%-1.8%) for vasopressin, and 0.9% (95% CI, 0.1%-11.5%) for metaraminol. When considering all vasopressors collectively, the pooled minor AE incidence was 2.3% (95% CI, 1.5%-3.7%). Regarding major AEs, 30 venous thromboembolism events occurred, all in the 4 studies (8.1%) using midline catheters (1126 total catheters), with a pooled incidence of 1.4% (95% CI, 0.4%-5.4%). In contrast, only 1 major AE (a tissue necrosis event) was reported in 43 studies (87.8%) using short PIV catheters (29\u202f596 total catheters), with a pooled incidence of 0.0% (95% CI, 0.0%-0.0%). CVC avoidance ranged from 0% to 100%, with a pooled proportion of 59.7% (95% CI, 46.4%-71.7%) in 38 studies (77.6%) including 15\u202f371 catheters.<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  In this systematic review and meta-analysis of adult patients, AE incidence was low after short-term vasopressor administration through PIV catheters, particularly short catheters. These findings suggest that PIV administration might reduce the need for CVC placement with appropriate monitoring.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Critical Care Medicine Inc […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30489"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30489"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30489\/revisions"}],"predecessor-version":[{"id":31041,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30489\/revisions\/31041"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}