{"id":30472,"date":"2026-03-28T04:09:00","date_gmt":"2026-03-27T20:09:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=30472"},"modified":"2026-03-28T06:40:20","modified_gmt":"2026-03-27T22:40:20","slug":"icu-management-practice-%e4%b8%80%e9%a1%b9%e6%a0%87%e5%bf%97%e6%80%a7%e7%a0%94%e7%a9%b6%ef%bc%9a%e8%84%93%e6%af%92%e7%97%87%e9%a3%8e%e9%99%a9%e4%b8%8e%e9%95%bf%e6%9c%9f%e9%a2%84%e5%90%8e","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=30472","title":{"rendered":"[ICU Management &#038; Practice]: \u4e00\u9879\u6807\u5fd7\u6027\u7814\u7a76\uff1a\u8113\u6bd2\u75c7\u98ce\u9669\u4e0e\u957f\u671f\u9884\u540e"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Landmark Study: Sepsis Risk and Long-Term Outcomes<\/h1>\n\n\n\n<ul>\n<li>In&nbsp;<a href=\"https:\/\/healthmanagement.org\/c\/sepsis\">Sepsis<\/a><\/li>\n\n\n\n<li>Tue, 17 Mar 2026<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/res.cloudinary.com\/healthmanagement-org\/image\/upload\/f_auto\/q_90\/fl_lossy\/v1773750612\/cw\/00132250_cw_image_admin_b6d9dc7d9e47f180587d5d0af72d0ade.webp?_a=BAAABnBs\" alt=\"\"\/><\/figure>\n\n\n\n<p>A landmark population-based study on the developmental risk factors and long-term consequences of sepsis was previewed at ISICEM this afternoon. Djillali Annane, director of the ICU and the IHU-PROMETHEUS Comprehensive Sepsis Center at Raymond Poincar\u00e9 Hospital in Paris, presented early insights from the ongoing research in a French cohort.<\/p>\n\n\n\n<p>Drawing on more than 25 years of data from a large general population sample, the study compared individuals who developed and were treated for sepsis with those who did not. According to Prof Annane, this is the first study to follow patients from before the onset of sepsis and track outcomes over 10\u201315 years. There is no other study that has followed patients since before they acquired sepsis.<\/p>\n\n\n\n<p>The research is based on the Constances cohort, a large-scale database of approximately 270,000 adults. Participants, initially enrolled while healthy, are followed throughout their lives, allowing researchers to identify factors preceding sepsis and assess its long-term impact compared with those who never develop the condition.<\/p>\n\n\n\n<p>The team aims to uncover not only predisposing factors but also potential links between sepsis and long-term conditions such as chronic disease and cancer. Prof Annane highlighted growing evidence of persistent immune dysregulation in sepsis survivors, which may contribute to increased cancer risk.<\/p>\n\n\n\n<p>The study was partly motivated by global efforts following the Seventieth World Health Assembly resolution calling for stronger action to reduce the burden of sepsis. In response, France implemented a national strategy emphasising improved epidemiological data.<\/p>\n\n\n\n<p>Although sepsis was not initially coded in the Constances dataset, it can be reliably identified through detailed infection records and evidence of new organ dysfunction. The research team, comprising epidemiologists, statisticians, and junior researchers, has spent nearly two years analysing the data and expects to submit findings for publication by the end of 2026.<\/p>\n\n\n\n<p>Handling such a vast dataset presents challenges, particularly given changes in medical practice over the past 25 years. To address confounding factors, the team is applying a range of methods, including matching, multivariable regression, and machine learning techniques.<\/p>\n\n\n\n<p><br \/>So far, approximately 1,700 sepsis cases have been identified within the cohort, aligning closely with national incidence estimates. Given the novelty and scale of the dataset, the team is proceeding cautiously, prioritising rigorous validation to ensure accurate and reliable conclusions.<\/p>\n\n\n\n<p>Source: ISICEM<br \/>Image Credit: iStock<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Landmark Study: Sepsis Risk and Long-Term Outcomes A la [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[24,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30472"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30472"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30472\/revisions"}],"predecessor-version":[{"id":30473,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30472\/revisions\/30473"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}