{"id":30436,"date":"2026-03-25T04:14:00","date_gmt":"2026-03-24T20:14:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=30436"},"modified":"2026-03-25T05:45:36","modified_gmt":"2026-03-24T21:45:36","slug":"nejm%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%80%a5%e6%80%a7%e4%bd%8e%e6%b0%a7%e8%a1%80%e7%97%87%e6%80%a7%e5%91%bc%e5%90%b8%e5%8a%9f%e8%83%bd%e8%a1%b0%e7%ab%ad%e7%9a%84%e9%ab%98%e6%b5%81","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=30436","title":{"rendered":"[NEJM\u53d1\u8868\u8bba\u6587]\uff1a\u6025\u6027\u4f4e\u6c27\u8840\u75c7\u6027\u547c\u5438\u529f\u80fd\u8870\u7aed\u7684\u9ad8\u6d41\u91cf\u6c27\u7597\u4e0e\u6807\u51c6\u6c27\u7597"},"content":{"rendered":"\n

ORIGINAL ARTICLE<\/a><\/p>\n\n\n\n

High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure<\/h1>\n\n\n\n

Jean-Pierre\u00a0Frat,\u00a0Jean-Pierre\u00a0Quenot,\u00a0Christophe\u00a0Guitton,\u00a0et al<\/h3>\n\n\n\n

N Engl J Med Published\u00a0March 17, 2026<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

BACKGROUND<\/h3>\n\n\n\n

Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure.<\/p>\n\n\n\n

METHODS<\/h3>\n\n\n\n

In this multicenter, open-label trial, we randomly assigned patients who had acute hypoxemic respiratory failure to receive high-flow-oxygen or standard-oxygen therapy. All the patients had a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of 200 or less, a respiratory rate of more than 25 breaths per minute, and pulmonary infiltrate on chest imaging. The primary outcome was death by day 28.<\/p>\n\n\n\n

RESULTS<\/h3>\n\n\n\n

A total of 1116 patients underwent randomization. Of these patients, 1110 (556 in the high-flow-oxygen group and 554 in the standard-oxygen group) were included in the analysis. Mortality at day 28 was 14.6% (in 81 of 556 patients) in the high-flow-oxygen group and 14.6% (in 81 of 554 patients) in the standard-oxygen group (difference, \u22120.05 percentage points; 95% confidence interval [CI], \u22124.21 to 4.10; P=0.98). The incidence of intubation by day 28 was 42.4% (in 236 of 556 patients) in the high-flow-oxygen group and 48.4% (in 268 of 554 patients) in the standard-oxygen group (difference, \u22125.93 percentage points; 95% CI, \u221211.78 to \u22120.08). Serious adverse events (cardiac arrest or pneumothorax) occurred during spontaneous breathing in 13 patients (2.3%) in the high-flow-oxygen group and in 6 patients (1.1%) in the standard-oxygen group.<\/p>\n\n\n\n

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CONCLUSIONS<\/h3>\n\n\n\n

Among patients with acute hypoxemic respiratory failure, the use of oxygen delivered through a high-flow nasal cannula did not significantly reduce mortality at day 28. (Funded by the French Ministry of Health and Fisher and Paykel Healthcare; SOHO ClinicalTrials.gov number, NCT04468126<\/a>.)<\/p>\n","protected":false},"excerpt":{"rendered":"

ORIGINAL ARTICLE High-Flow or Standard Oxygen in Acute […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30436"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30436"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30436\/revisions"}],"predecessor-version":[{"id":30442,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30436\/revisions\/30442"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}