{"id":30259,"date":"2026-04-27T04:24:00","date_gmt":"2026-04-26T20:24:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=30259"},"modified":"2026-04-27T05:38:14","modified_gmt":"2026-04-26T21:38:14","slug":"intensive-care-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%9c%80%e8%a6%81crrt%e6%94%af%e6%8c%81%e7%9a%84ecmo%e6%82%a3%e8%80%85%e7%ae%a1%e8%b7%af%e6%95%b4%e5%90%88%e4%b8%8e%e5%88%86%e7%a6%bb","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=30259","title":{"rendered":"[Intensive Care Med\u53d1\u8868\u8bba\u6587]\uff1a\u9700\u8981CRRT\u652f\u6301\u7684ECMO\u60a3\u8005\u7ba1\u8def\u6574\u5408\u4e0e\u5206\u79bb\u65f6\u7ba1\u8def\u5bff\u547d\u7684\u6bd4\u8f83"},"content":{"rendered":"\n
Article<\/p>\n\n\n\n
The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial)<\/h1>\n\n\n\n
Intensive Care Med<\/em>\u00a0(2026). https:\/\/doi.org\/10.1007\/s00134-026-08302-y<\/h3>\n\n\n\n
Abstract<\/h2>\n\n\n\n
Background<\/h3>\n\n\n\n
The estimated incidence of acute kidney injury requiring renal replacement therapy (RRT), mainly continuous RRT (CRRT), in patients necessitating extracorporeal membrane oxygenation (ECMO) is approximately 50%. Currently, two well-known techniques, integration and separation, are utilized for combining CRRT and ECMO circuits, neither of which is considered a standard treatment.<\/p>\n\n\n\n
Purpose<\/h3>\n\n\n\n
This study aimed to compare circuit lifespan of CRRT between these two techniques during ECMO support.<\/p>\n\n\n\n
Methods<\/h3>\n\n\n\n
A multicentered randomized controlled trial was conducted from May 2021 to March 2025. ECMO patients who required CRRT support were enrolled. Primary outcome was CRRT circuit lifespan.<\/p>\n\n\n\n
Results<\/h3>\n\n\n\n
Eighty patients were recruited, with 40 allocated to the integration group and 40 to the separation group. Median circuit lifespan did not significantly differ between the groups (72\u00a0h [IQR 45\u201396.5] vs. 71\u00a0h [IQR 45\u201384];\u00a0p<\/em>\u2009=\u20090.52). Twenty-eight-day mortality rates were also comparable (32.5% vs. 35%;\u00a0p<\/em>\u2009=\u20090.81). No significant differences were observed in the incidence of serious adverse events, including air embolism. Transmembrane pressure and CRRT machine alarm frequencies were similar between groups.<\/p>\n\n\n\n<\/figure>\n\n\n\n<\/figure>\n\n\n\n<\/figure>\n\n\n\n
Conclusion<\/h3>\n\n\n\n
Among critically ill ECMO patients receiving CRRT, there is no significant difference in filter lifespan and serious adverse events between integrating the CRRT circuit into the ECMO circuit and using a separate circuit.<\/p>\n\n\n\n
Article The comparison of circuit lifespan between inte […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30259"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30259"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30259\/revisions"}],"predecessor-version":[{"id":30260,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/30259\/revisions\/30260"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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