{"id":29981,"date":"2026-03-16T04:01:00","date_gmt":"2026-03-15T20:01:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=29981"},"modified":"2026-03-16T05:42:47","modified_gmt":"2026-03-15T21:42:47","slug":"clin-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%98%bf%e6%a0%b9%e5%bb%b7%e7%9a%84%e8%80%90%e7%a2%b3%e9%9d%92%e9%9c%89%e7%83%af%e9%9d%a9%e5%85%b0%e9%98%b4%e6%80%a7%e6%9d%86%e8%8f%8c","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=29981","title":{"rendered":"[Clin Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u963f\u6839\u5ef7\u7684\u8010\u78b3\u9752\u9709\u70ef\u9769\u5170\u9634\u6027\u6746\u83cc\u83cc\u8840\u75c7"},"content":{"rendered":"\n

JOURNAL ARTICLE<\/p>\n\n\n\n

Carbapenem-Resistant Gram-Negative Bacilli Bacteremia in Argentina (EMBARCAR): Findings From a Prospective, Multicenter Cohort Study<\/h1>\n\n\n\n

Juan Pablo Balbuena, Ezequiel Cordova, Analia Mykietiuk, et al<\/h3>\n\n\n\n

Clin Infect Dis Volume 81, Issue 5, 15 November 2025, Pages 879\u2013888, https:\/\/doi.org\/10.1093\/cid\/ciaf259<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

Bloodstream infections (BSIs) caused by carbapenem-resistant gram-negative bacilli (CR-GNB) are difficult-to-treat infections associated with high mortality. Outcomes of BSI due to CR-GNB may vary in different countries.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

Prospective observational, multicenter study, including consecutive hospitalized index patients aged \u226518 years, with a positive blood culture for CR-GNB, between July 2020 and March 2022 in Argentina. Among patients with Klebsiella pneumoniae<\/em> BSIs, logistic regressions adjusted by propensity score (PS) were used to identify variables associated with 30-day mortality.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

Overall, 466 patients with CR-GNB BSIs were included. The mean age was 56.7 (SD \u00b116) years and most patients (75%) were in critical care units. The median INCREMENT-CPE mortality score was 10 (IQR, 6\u201312). Most common micro-organisms were\u00a0K pneumoniae<\/em>\u00a0(53%) and\u00a0Acinetobacter baumannii<\/em>\u00a0(25%). Among Enterobacterales, resistance mechanisms included\u00a0K pneumoniae<\/em>\u00a0carbapenemase (KPC) in 50%, metallo-beta-lactamase carbapenemase (MBL) in 48%, OXA carbapenemase in 6%, and a combination of carbapenemases in 5% of patients. Overall, 30-day mortality was 52%. Among patients with BSI due to\u00a0K pneumoniae<\/em>, the PS-adjusted multivariate analysis showed that an INCREMENT-CPE score \u22658 points (odds ratio [OR], 3.48; 95% CI, 1.53, 7.93) was associated with increased 30-day mortality. In contrast, the use of regimens including ceftazidime-avibactam alone or in combination with aztreonam was associated with decreased 30-day mortality (OR, .20; 95% CI, .09, .47).<\/p>\n\n\n\n

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Conclusions<\/p>\n\n\n\n

BSIs due to CR-GNB are associated with high mortality rates in Argentina. Among patients with CR-K pneumoniae<\/em> bacteremia the use of ceftazidime-avibactam alone or in combination with aztreonam was associated with a reduction in mortality.<\/p>\n","protected":false},"excerpt":{"rendered":"

JOURNAL ARTICLE Carbapenem-Resistant Gram-Negative Baci […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29981"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29981"}],"version-history":[{"count":3,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29981\/revisions"}],"predecessor-version":[{"id":30335,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29981\/revisions\/30335"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}