{"id":29714,"date":"2026-01-29T04:09:00","date_gmt":"2026-01-28T20:09:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=29714"},"modified":"2026-01-29T05:34:57","modified_gmt":"2026-01-28T21:34:57","slug":"chest%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%bf%83%e8%b7%b3%e9%aa%a4%e5%81%9c%e5%90%8e%e7%9a%84%e6%b0%a7%e9%a5%b1%e5%92%8c%e5%ba%a6%e7%9b%ae%e6%a0%87%e4%b8%8e%e7%a5%9e%e7%bb%8f%e7%b3%bb","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=29714","title":{"rendered":"[Chest\u53d1\u8868\u8bba\u6587]\uff1a\u5fc3\u8df3\u9aa4\u505c\u540e\u7684\u6c27\u9971\u548c\u5ea6\u76ee\u6807\u4e0e\u795e\u7ecf\u7cfb\u7edf\u9884\u540e"},"content":{"rendered":"\n

CRITICAL CARE: ORIGINAL RESEARCH<\/strong><\/p>\n\n\n\n

Oxygen Saturation Targets and Neurologic Outcomes Following Cardiac Arrest: A Secondary Analysis of the Pragmatic Investigation of Optimal Oxygen Targets Trial<\/h1>\n\n\n\n

Stephanie C.\u00a0DeMasi,\u00a0Alexander T.\u00a0Clark,\u00a0Amelia L.\u00a0Muhs,\u00a0et al<\/h3>\n\n\n\n

Chest 2025; 168: 1131-1140<\/h3>\n\n\n\n

DOI:\u00a010.1016\/j.chest.2025.04.027\u00a0External Link<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

More than 600,000 adults in the United States experience an out-of-hospital or in-hospital cardiac arrest each year. Following resuscitation from cardiac arrest, most patients receive mechanical ventilation. The oxygenation target that optimizes neurologic outcomes following cardiac arrest is uncertain.<\/p>\n\n\n\n

Research Question<\/h3>\n\n\n\n

Following cardiac arrest, does a lower oxygen saturation (Spo2<\/sub>) target improve neurologic outcomes compared with a higher Spo2<\/sub>target?<\/p>\n\n\n\n

Study Design and Methods<\/h3>\n\n\n\n

This study was a secondary analysis of patients who experienced a cardiac arrest prior to enrollment in the Pragmatic Investigation of Optimal Oxygen Targets (PILOT) trial. The PILOT trial assigned critically ill adults receiving mechanical ventilation to a lower (88%-92%), intermediate (92%-96%), or higher (96%-100%) Spo2<\/sub> target. This subgroup analysis compared patients randomized to a lower or intermediate Spo2<\/sub> target (88-96%) vs a higher Spo2<\/sub> target (96%-100%) regarding the primary outcome of survival with a favorable neurologic outcome at hospital discharge (Cerebral Performance Category 1 or 2).<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Of 2,987 patients in the PILOT trial, 339 (11.3%) experienced a cardiac arrest prior to enrollment: 221 were assigned to a lower or intermediate Spo2<\/sub>\u00a0target, and 118 were assigned to a higher Spo2<\/sub>\u00a0target. Overall, the median age was 60 years, 43.5% were female, 58.7% experienced an in-hospital cardiac arrest, and 10.2% had an initial shockable rhythm. Survival with a favorable neurologic outcome occurred in 50 patients (22.6%) assigned to a lower or intermediate Spo2<\/sub>\u00a0target and 15 (12.7%) patients assigned to a higher Spo2<\/sub>\u00a0target (absolute risk difference, 9.9 percentage points; 95% CI, 1.8-18.1;\u00a0P<\/em>\u00a0= .03).<\/p>\n\n\n\n

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Interpretation<\/h3>\n\n\n\n

Among patients receiving mechanical ventilation following a cardiac arrest, use of a lower or intermediate Spo2<\/sub> target was associated with a higher incidence of a favorable neurologic outcome compared with a higher target. A randomized trial comparing these targets in the cardiac arrest population is needed to confirm these findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

CRITICAL CARE: ORIGINAL RESEARCH Oxygen Saturation Targ […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29714"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29714"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29714\/revisions"}],"predecessor-version":[{"id":29715,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29714\/revisions\/29715"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}