{"id":29503,"date":"2026-02-19T04:07:00","date_gmt":"2026-02-18T20:07:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=29503"},"modified":"2026-02-19T09:21:05","modified_gmt":"2026-02-19T01:21:05","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e4%ba%ba%e5%b7%a5%e6%99%ba%e8%83%bd%e8%b5%8b%e8%83%bd%e7%94%9f%e6%b4%bb%e6%96%b9%e5%bc%8f%e5%b9%b2%e9%a2%84%e4%b8%8e%e4%ba%ba%e7%b1%bb%e6%8c%87","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=29503","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u4eba\u5de5\u667a\u80fd\u8d4b\u80fd\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u4e0e\u4eba\u7c7b\u6307\u5bfc\u7cd6\u5c3f\u75c5\u9884\u9632\u8ba1\u5212"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

AI in Medicine<\/p>\n\n\n\n

An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program: A Randomized Clinical Trial<\/h1>\n\n\n\n

Nestoras Mathioudakis, Benjamin Lalani, Mohammed S. Abusamaan, et al<\/h3>\n\n\n\n

JAMA Published Online: October 27, 2025<\/h3>\n\n\n\n

doi: 10.1001\/jama.2025.19563<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  How does referral to a lifestyle intervention exclusively driven by artificial intelligence (AI) compare with referral to a human coach\u2013led Diabetes Prevention Program (DPP) lifestyle intervention?<\/p>\n\n\n\n

Findings<\/strong>  In this randomized clinical trial involving 368 adults with overweight or obesity and prediabetes, 31.7% of participants randomized to referral to an AI-led DPP and 31.9% of participants randomized to referral to a human-led DPP group achieved the primary composite outcome (5% weight loss, 4% weight loss plus 150 minutes of physical activity per week, or an absolute hemoglobin A1c<\/sub> reduction of \u22650.2 percentage points with hemoglobin A1c<\/sub> maintained at <6.5% throughout the study duration) at 12 months, a difference that met the prespecified noninferiority criterion of 15%.<\/p>\n\n\n\n

Meaning<\/strong>  Among adults with prediabetes and overweight or obesity, a fully automated AI-led DPP may be a viable alternative to a DPP led by human coaches.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Prediabetes is common, yet evidence-based lifestyle interventions are underutilized.<\/p>\n\n\n\n

Objective<\/strong>  To determine whether referral to an exclusively artificial intelligence (AI)\u2013led lifestyle intervention based on the Diabetes Prevention Program (DPP) is noninferior to referral to a human-led DPP in achieving recommended thresholds for weight loss, hemoglobin A1c<\/sub> (HbA1c<\/sub>) reduction, and weekly physical activity among adults with prediabetes and overweight or obesity.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This phase 3, parallel-group, pragmatic, noninferiority randomized clinical trial was conducted from October 11, 2021, to December 16, 2024 (last follow-up) at 2 US clinical sites in Baltimore, Maryland, and Reading, Pennsylvania. Adults 18 years or older with prediabetes and overweight or obesity were enrolled.<\/p>\n\n\n\n

Interventions<\/strong>  Participants were randomized in a 1:1 ratio to receive either a referral to an AI-powered DPP lifestyle intervention delivered via a mobile app and Bluetooth-enabled digital scale or a referral to a human coach\u2013led DPP lifestyle intervention delivered remotely. Both interventions were delivered independently of the study team over a 12-month period.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was a composite of maintaining an HbA1c<\/sub> less than 6.5% throughout the study and achievement of at least 5% weight loss, at least 4% weight loss plus at least 150 minutes of weekly physical activity (assessed with actigraphy), or an absolute reduction in HbA1c<\/sub> of at least 0.2 percentage points at 12 months. Noninferiority of referral to the AI-led DPP compared with referral to the human-led DPP was prespecified to be determined if the 1-sided 95% CI lower boundary of the risk difference did not cross \u221215%.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0A total of 368 participants were included (median [IQR] age, 58 [50-65] years; 71% were female, 27% were Black, 6% were Hispanic, and 61% were White; median [IQR] BMI, 32.3 [28.5-37.1]). After referral, 171 of 183 participants (93.4%) initiated the AI-led DPP and 153 of 185 (82.7%) initiated the human-led DPP. The primary outcome was achieved by 58 of 183 participants (31.7%) in the AI-led DPP group and 59 of 185 (31.9%) in the human-led DPP group (risk difference, \u22120.2% [1-sided 95% CI, \u22128.2%]), meeting the criterion for noninferiority. Findings were consistent across individual components of the composite end point and in sensitivity analyses.<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  Among adults with prediabetes and overweight or obesity, referral to a fully automated AI-led DPP was noninferior to referral to a human-led DPP in achieving a composite outcome based on weight reduction, physical activity, and HbA1c<\/sub>.<\/p>\n\n\n\n

Trial Registration<\/strong>  ClinicalTrials.gov Identifier: NCT05056376<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  AI in Medicine An AI-Power […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29503"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29503"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29503\/revisions"}],"predecessor-version":[{"id":30138,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29503\/revisions\/30138"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29503"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}