{"id":29381,"date":"2025-12-05T04:03:00","date_gmt":"2025-12-04T20:03:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=29381"},"modified":"2025-12-05T05:45:59","modified_gmt":"2025-12-04T21:45:59","slug":"jama-netw-open%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e4%bd%bf%e7%94%a8%e7%a9%ba%e6%b0%94%e5%87%80%e5%8c%96%e5%99%a8%e5%87%8f%e5%b0%91%e5%b0%8f%e5%ad%a6%e5%91%bc%e5%90%b8%e9%81%93%e7%97%85","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=29381","title":{"rendered":"[JAMA Netw Open\u53d1\u8868\u8bba\u6587]\uff1a\u4f7f\u7528\u7a7a\u6c14\u51c0\u5316\u5668\u51cf\u5c11\u5c0f\u5b66\u547c\u5438\u9053\u75c5\u6bd2\u66b4\u9732"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Public Health<\/p>\n\n\n\n

Air Purifier Intervention for Respiratory Viral Exposure in Elementary Schools: A Secondary Analysis of a Randomized Clinical Trial<\/h1>\n\n\n\n

Ye Sun, Dastan Haghnazari, Ching-Ying Huang, et al<\/h3>\n\n\n\n

JAMA Netw Open 2025;8;(10):e2536951. doi:10.1001\/jamanetworkopen.2025.36951<\/h3>\n\n\n\n

Key Points<\/h3>\n\n\n\n

Question<\/strong>  Is the use of high-efficiency particulate air (HEPA) purifiers associated with reduced respiratory virus exposure in elementary school classrooms?<\/p>\n\n\n\n

Findings<\/strong>  In this secondary analysis of a randomized clinical trial of 200 classrooms, respiratory viral exposures were high; HEPA purifiers were not associated with an overall reduction in viral burden.<\/p>\n\n\n\n

Meaning<\/strong>  Mitigating respiratory viral exposures in schools may require multicomponent interventions, including addressing both air filtration and additional indoor environmental factors.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  The magnitude of school respiratory virus exposure and the effectiveness of environmental mitigation measures remain unclear.<\/p>\n\n\n\n

Objective<\/strong>  To evaluate whether portable high-efficiency particulate air (HEPA) purifiers are associated with reduced respiratory virus exposure in elementary school classrooms.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This ad hoc secondary analysis was performed between July 2023 and September 2024 and used data from a cluster-randomized, placebo-controlled trial (School Inner-City Asthma Intervention Study) of HEPA purifiers conducted from September 2015 to June 2020. A total of 200 classrooms from 39 public schools in Northeastern US were enrolled and randomized.<\/p>\n\n\n\n

Interventions<\/strong>  Classrooms were randomized 1:1 to receive either active HEPA purifiers or visually identical sham HEPA units (4 per classroom). School staff and investigators were blinded to intervention assignments.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was high viral exposure, identified by K-means clustering of individual viral concentrations. Secondary outcomes included viral diversity (defined as number of detected virus types) and individual viral concentrations. Week-long bioaerosol samples were collected 3 times during 1 school year, and concentrations of 19 respiratory viruses were quantified by digital droplet polymerase chain reaction.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0Of the 200 enrolled classrooms (91 in the sham purifier group and 109 in the HEPA purifier group) analyzed, the median (IQR) class size was 19 (18-20) and the median (IQR) grade was 3 (2-5). A total of 532 bioaerosol samples were collected; viruses were detected in 524 samples (98.5%), with a median (IQR) of 3 (2-5) viruses per classroom. Rhinovirus was most prevalent (476 [89.5%]), while respiratory syncytial virus A and B (66 [12.4%] and 127 [23.9%]) as well as influenza A and B (94 [17.7%] and 76 [14.3%]) were also detected. High viral exposure was present in 118 samples (22.2%). The HEPA purifier intervention was not associated with lower odds of high viral exposure (odds ratio [OR], 0.50; 95% CI, 0.08-3.25;\u00a0P<\/em>\u2009=\u2009.46) but did correspond to a modest reduction in viral diversity (\u03b2\u2009=\u2009\u22121.02; 95% CI, \u20131.68 to \u22120.35;\u00a0P<\/em>\u2009=\u2009.003). Elastic net regression identified relative humidity, grade, winter season, and coarse particulate matter as the environmental risk factors for viral exposure.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Conclusions and Relevance<\/strong>  In this secondary analysis, HEPA purifiers were not associated with a reduction in high viral exposure but were associated with a modest decrease in viral diversity. Multicomponent interventions may be needed to mitigate respiratory viral exposures in schools.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Public Health Air Purifier […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29381"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29381"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29381\/revisions"}],"predecessor-version":[{"id":29674,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29381\/revisions\/29674"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29381"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29381"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29381"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}